• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Transmembrane Protein 2 (CEMIP2) Antibody – Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS857144

Transmembrane protein 2 is a single-pass membrane protein, which consists of 1383 amino acids. TMEM2 belongs to TMEM2 family, contains 3 PbH1 repeats. It is widely expressed. More details

$385 / 0.1 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Transmembrane protein 2 (CEMIP2), Polyclonal Antibody
Full Product Name
Transmembrane protein 2 Antibody
Product Gene Name
Clonality
Polyclonal
Species Reactivity
Human, Mouse
Form/Format
1*TBS (pH7.4), 0.5%BSA, 25% Glycerol.
Purity/Purification
Affinity purified
Specificity
This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to transmembrane protein 2.
Preparation and Storage
Store at +4 degree C after thawing. Aliquot store at-20 degree C or-80 degree C. Avoid repeated freeze/thaw cycles.
Molecular Weight
55; 85kDa
OMIM
605835
3D Structure
ModBase 3D Structure for Q9UHN6
Preservative
0.05% Sodium Azide.
Cellular Localization
Cell Membrane
Positive Control
Mouse Heart
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-CEMIP2 antibody
Western Blot (WB)
Application Notes for anti-CEMIP2 antibody
WB: 1:1,000-1:2,000

Western Blot of anti-CEMIP2 antibody

Western blot analysis on mouse heart using anti- TMEM2 polyclonal antibody.
Anti-CEMIP2 Polyclonal Antibody – Cat# MBS857144

Product References and Citations for anti-CEMIP2 antibody

1. "Refining the DFNB7-DFNB11 deafness locus using intragenic polymorphisms in a novel gene, TMEM2."Scott D.A., Drury S., Sundstrom R.A., Bishop J., Swiderski R.E., Carmi R., Ramesh A., Elbedour K., Srikumari Srisailapathy C.R., Keats B.J., Sheffield V.C., Smith R.J.H.Gene 246:265-274(2000). 2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.DNA Res. 9:99-106(2002).

Other Notes

Small volumes of anti-CEMIP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CEMIP2 purchase

MBS857144 is an antibody targeting CEMIP2. Also known as Transmembrane protein 2 Antibody. Reactive in Human, Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CEMIP2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
cell surface hyaluronidase isoform b
NCBI Official Synonym Full Names
cell migration inducing hyaluronidase 2
NCBI Official Symbol
CEMIP2
NCBI Official Synonym Symbols
TMEM2
UniProt Protein Name
Cell surface hyaluronidase
UniProt Synonym Protein Names
Transmembrane protein 2
Protein Family
UniProt Gene Name
TMEM2
NCBI Protein Information
cell surface hyaluronidase

NCBI Summary for CEMIP2

This gene encodes a type II transmembrane protein that belongs to the interferon-induced transmembrane (IFITM) protein superfamily. The encoded protein functions as a cell surface hyaluronidase that cleaves extracellular high molecular weight hyaluronan into intermediate size fragments before internalization and degradation in the lysosome. It also has an interferon-mediated antiviral function in humans through activation of the JAK STAT signaling pathway. The activation of this gene by transcription factor SOX4 in breast cancer cells has been shown to mediate the pathological effects of SOX4 on cancer progression. Naturally occurring mutations in this gene are associated with autosomal recessive non-syndromic hearing loss. [provided by RefSeq, Mar 2017]
Show more

UniProt Comments for CEMIP2

Cell surface hyaluronidase that mediates the initial cleavage of extracellular high-molecular-weight hyaluronan into intermediate-size hyaluronan of approximately 5 kDa fragments (PubMed:28246172). Acts as a regulator of angiogenesis and heart morphogenesis by mediating degradation of extracellular hyaluronan, thereby regulating VEGF signaling (). Is very specific to hyaluronan; not able to cleave chondroitin sulfate or dermatan sulfate (PubMed:28246172).
Show more

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000