Insulin Receptor Beta (INSR) Antibody – Rabbit

FMS-related tyrosine kinase 3 (FLT3, also called Flk2), is a member of the type III receptor tyrosine kinase family, which includes c-Kit, PDGFR and M-CSF receptors. FLT3 is expressed on early hematopoietic progenitor cells and supports growth and differentiation within the hematopoietic system (1, 2). FLT3 is activated after binding with its ligand FL, which results in a cascade of tyrosine autophosphorylation and tyrosine phosphorylation of downstream targets (3). The p85 subunit of PI3 kinase, SHP2, GRB2 and Shc are associated with FLT3 after FL stimulation (4-6). Tyr589/591 is located in the juxtamembrane region of FLT3 and may play an important role in regulation of FLT3 tyrosine kinase activity. Somatic mutations of FLT3 consisting of internal tandem duplications (ITDs) occur in 20% of patients with acute myeloid leukemia (7).

1. Shurin, M.R. et al. (1998) Cytokine Growth Factor Rev. 9, 37-48. 2. Naoe, T. et al. (2001) Cancer Chemother. Pharmacol. 48 Suppl1, S27-S30. 3. Namikawa, R. et al. (1996) Stem Cells 14, 388-395. 4. Beslu, N. et al. (1996) J. Biol. Chem. 271, 20075-20081. 5. Zhang, S. and Broxmeyer, H.E. (2000) Biochem. Biophys. Res. Commun. 277, 195-199. 6. Zhang, S. et al. (1999) J. Leukoc. Biol. 65, 372-380. 7. Mizuki, M. et al. (2000) Blood 96, 3907-3914.

Small volumes of anti-INSR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS857297 is an antibody targeting INSR. Also known as Insulin Receptor beta Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.