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LEG8 Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS858324

MBS858324 is an antibody targeting LEG8. Also known as LEG8 Antibody. Reactive in Human, Mouse. More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
LEG8, Antibody
Full Product Name
LEG8 Antibody
Product Gene Name
Product Synonym Names
Galectin-8; Gal-8; Prostate carcinoma tumor antigen 1; PCTA-1; Po66 carbohydrate-binding protein; Po66-CBP; LGALS8
Species Reactivity
Human, Mouse
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Specificity
LEG8 antibody detects endogenous levels of total LEG8 protein.
Preparation and Storage
Store at-20 degree C for 1 year.
Molecular Weight
40,397 Da
OMIM
606099
3D Structure
ModBase 3D Structure for O00214
Immunogen
The antiserum was produced against synthesized peptide derived from internal of human LEG8.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-LEG8 antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-LEG8 antibody
WB: 1:500~1:1000
IHC: 1:50~1:100
ELISA: 1:20000

Testing Data of anti-LEG8 antibody

Peptide-+
Anti-LEG8 Antibody – Cat# MBS858324

Immunohistochemistry (IHC) of anti-LEG8 antibody

Immunohistochemistry analysis of paraffin-embedded human prostate carcinoma tissue using LEG8 antibody. Western blot analysis of extracts from 3T3 cells, using LEG8 antibody.
Anti-LEG8 Antibody, Immunohistochemistry (IHC) – Cat# MBS858324

Product References and Citations for anti-LEG8 antibody

Su Z.-Z., Proc. Natl. Acad. Sci. U.S.A. 93:7252-7257(1996). Hadari Y.R., Trends Glycosci. Glycotechnol. 9:103-112(1997). Gopalkrishnan R.V., Oncogene 19:4405-4416(2000).

Other Notes

Small volumes of anti-LEG8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for LEG8. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
galectin-8 isoform a
NCBI Official Synonym Full Names
galectin 8
NCBI Official Symbol
LGALS8
NCBI Official Synonym Symbols
Gal-8; PCTA1; PCTA-1; Po66-CBP
UniProt Protein Name
Galectin-8
UniProt Synonym Protein Names
Po66 carbohydrate-binding protein; Po66-CBP; Prostate carcinoma tumor antigen 1
UniProt Gene Name
LGALS8
UniProt Synonym Gene Names
PCTA-1
NCBI Protein Information
galectin-8

NCBI Summary for LEG8

This gene encodes a member of the galectin family. Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains. The galectins have been implicated in many essential functions including development, differentiation, cell-cell adhesion, cell-matrix interaction, growth regulation, apoptosis, and RNA splicing. This gene is widely expressed in tumoral tissues and seems to be involved in integrin-like cell interactions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
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UniProt Comments for LEG8

Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy (PubMed:22246324, PubMed:28077878). Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane; these ligands becoming exposed to the cytoplasm following rupture (PubMed:22246324, PubMed:28077878). Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52 (PubMed:22246324, PubMed:28077878). Required to restrict infection of bacterial invasion such as S.typhimurium (PubMed:22246324). Also required to restrict infection of Picornaviridae viruses (PubMed:28077878). Has a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans (PubMed:21288902).
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-LEG8 antibody

 Reference Product  PubMed Publications
 ITGA4 antibody  >1 publications with LEG8 and ITGA4
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