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POLR1E Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS858417

MBS858417 is an antibody targeting POLR1E. Also known as POLR1E Antibody. Reactive in Human. More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
POLR1E, Antibody
Full Product Name
POLR1E Antibody
Product Gene Name
anti-POLR1E antibody
Product Synonym Names
DNA-directed RNA polymerase I RPA49; DNA-directed RNA polymerase I subunit E; PAF53; polymerase (RNA) I polypeptide E; 53kDa; PRAF1; RNA polymerase I A49; RNA polymerase I-associated factor 1; RNA polymerase I-associated factor 53; RPA49
Species Reactivity
Human
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Specificity
POLR1E antibody detects endogenous levels of total POLR1E protein.
Preparation and Storage
Store at-20 degree C for 1 year.
Molecular Weight
47,260 Da
3D Structure
ModBase 3D Structure for Q9GZS1
Immunogen
The antiserum was produced against synthesized peptide derived from internal of human POLR1E.

Product Categories/Family for anti-POLR1E antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-POLR1E antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-POLR1E antibody
WB: 1:500~1:1000
IHC: 1:50~1:100
ELISA: 1:10000

Testing Data of anti-POLR1E antibody

Peptide-+
Anti-POLR1E Antibody – Cat# MBS858417

Immunohistochemistry (IHC) of anti-POLR1E antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using POLR1E antibody. Western blot analysis of extracts from MCF-7 cells, using POLR1E antibody.
Anti-POLR1E Antibody, Immunohistochemistry (IHC) – Cat# MBS858417

Product References and Citations for anti-POLR1E antibody

Ota T., Nat. Genet. 36:40-45(2004). Ebert L., Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases. Humphray S.J., Nature 429:369-374(2004).

Other Notes

Small volumes of anti-POLR1E antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for POLR1E. It may not necessarily be applicable to this product.

NCBI GI #
544346178
NCBI GeneID
64425
NCBI Accession #
NP_001269695.1
UniProt Primary Accession #
Q9GZS1
UniProt Secondary Accession #
Q5VZT3; Q8NBA9; Q96L20
UniProt Related Accession #
Q9GZS1
GenBank Nucleotide #
NM_001282766.1
NCBI Official Full Name
DNA-directed RNA polymerase I subunit RPA49 isoform 2
NCBI Official Synonym Full Names
RNA polymerase I subunit E
NCBI Official Symbol
POLR1E
NCBI Official Synonym Symbols
PAF53; PRAF1
UniProt Protein Name
DNA-directed RNA polymerase I subunit RPA49
UniProt Synonym Protein Names
DNA-directed RNA polymerase I subunit E; RNA polymerase I-associated factor 1; RNA polymerase I-associated factor 53
UniProt Gene Name
POLR1E
UniProt Synonym Gene Names
PAF53; PRAF1; RNA polymerase I subunit A49
NCBI Protein Information
DNA-directed RNA polymerase I subunit RPA49

UniProt Comments for POLR1E

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Appears to be involved in the formation of the initiation complex at the promoter by mediating the interaction between Pol I and UBTF/UBF ().
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Research Articles on POLR1E

1. Nucleolar detention requires binding of SIRT7 to nascent pre-rRNA, linking the spatial distribution of SIRT7 and deacetylation of PAF53 to ongoing transcription.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-POLR1E antibody

 Products by Pathway  Pathway Diagram
 Epigenetic Regulation Of Gene Expression Pathway antibodies  Epigenetic Regulation Of Gene Expression Pathway Diagram
 Eukaryotic Transcription Initiation Pathway antibodies  Eukaryotic Transcription Initiation Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Negative Epigenetic Regulation Of RRNA Expression Pathway antibodies  Negative Epigenetic Regulation Of RRNA Expression Pathway Diagram
 NoRC Negatively Regulates RRNA Expression Pathway antibodies  NoRC Negatively Regulates RRNA Expression Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram

Diseases associated with anti-POLR1E antibody

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >1 publications with POLR1E and Disease Models, Animal
 Neoplasms, Experimental Antibodies  >1 publications with POLR1E and Neoplasms, Experimental
 Liver Neoplasms, Experimental Antibodies  >1 publications with POLR1E and Liver Neoplasms, Experimental
 Liver Neoplasms Antibodies  >1 publications with POLR1E and Liver Neoplasms
 Liver Diseases Antibodies  >1 publications with POLR1E and Liver Diseases
 Necrosis Antibodies  >1 publications with POLR1E and Necrosis

Organs/Tissues associated with anti-POLR1E antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >1 publications with POLR1E and Muscle
 Liver Antibodies  >1 publications with POLR1E and Liver
 Bladder Antibodies  >1 publications with POLR1E and Bladder
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