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HIRA Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS858453

MBS858453 is an antibody targeting HIRA. Also known as HIRA (Ab-555) Antibody. Reactive in Human, Mouse. More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
HIRA, Antibody
Full Product Name
HIRA (Ab-555) Antibody
Product Gene Name
Product Synonym Names
DGCR1; TUP1 like enhancer of split protein 1; TUPLE1
Species Reactivity
Human, Mouse
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Specificity
HIRA antibody detects endogenous levels of total HIRA protein.
Preparation and Storage
Store at-20 degree C for 1 year.
Molecular Weight
89,299 Da
OMIM
600237
3D Structure
ModBase 3D Structure for P54198
Immunogen
The antiserum was produced against synthesized peptide derived from Internal of human HIRA.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-HIRA antibody
Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-HIRA antibody
IHC: 1:50-1:100
ELISA: 1:1000

Immunohistochemistry (IHC) of anti-HIRA antibody

Peptide-+ Immunohistochemistry analysis of paraffin-embedded human tonsil tissue using HIRA antibody.
Anti-HIRA Antibody – Cat# MBS858453

Product References and Citations for anti-HIRA antibody

Lamour V., Hum. Mol. Genet. 4:791-799(1995). Lorain S., Genome Res. 6:43-50(1996). Collins J.E., Genome Biol. 5:RESEARCH84.1-RESEARCH84.11(2004).

Other Notes

Small volumes of anti-HIRA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for HIRA. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
protein HIRA
NCBI Official Synonym Full Names
histone cell cycle regulator
NCBI Official Symbol
HIRA
NCBI Official Synonym Symbols
TUP1; DGCR1; TUPLE1
UniProt Protein Name
Protein HIRA
UniProt Synonym Protein Names
TUP1-like enhancer of split protein 1
Protein Family
UniProt Gene Name
HIRA
UniProt Synonym Gene Names
DGCR1; HIR; TUPLE1
NCBI Protein Information
protein HIRA

NCBI Summary for HIRA

This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development. [provided by RefSeq, Jul 2008]
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UniProt Comments for HIRA

Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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