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STAM2 Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS858553

MBS858553 is an antibody targeting STAM2. Also known as STAM2 (Phospho-Tyr192) Antibody. Reactive in Human, Mouse. More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
STAM2, Antibody
Full Product Name
STAM2 (Phospho-Tyr192) Antibody
Product Gene Name
Product Synonym Names
HBP; HRS binding protein; Signal transducing adaptor molecule (SH3 domain and ITAM motif) 2; Signal transducing adaptor molecule 2A; Signal transducing adaptor molecule 2B
Species Reactivity
Human, Mouse
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Specificity
STAM2 (Phospho-Tyr192) antibody detects endogenous levels of STAM2 only when phosphorylated at tyrosine 192.
Preparation and Storage
Store at-20 degree C for 1 year.
Molecular Weight
38,370 Da
OMIM
606244
3D Structure
ModBase 3D Structure for O75886
Immunogen
The antiserum was produced against synthesized phosphopeptide derived from human STAM2 around the phosphorylation site of tyrosine 192 (S-L-YP-P-S).
All Sites
Human: Tyr192
Mouse: Tyr192
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-STAM2 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-STAM2 antibody
WB: 1:500-1:1000
ELISA: 1:1000

Western Blot (WB) of anti-STAM2 antibody

Western blot analysis of extracts from NIH/3T3 cells, treated with EGF (200ng/ml, 30mins), using STAM2 (Phospho-Tyr192) antibody.
Anti-STAM2 Antibody – Cat# MBS858553

Product References and Citations for anti-STAM2 antibody

Endo K., FEBS Lett. 477:55-61(2000). Wiemann S., Genome Res. 11:422-435(2001). Hillier L.W., Nature 434:724-731(2005).

Other Notes

Small volumes of anti-STAM2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for STAM2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
signal transducing adapter molecule 2
NCBI Official Synonym Full Names
signal transducing adaptor molecule 2
NCBI Official Symbol
STAM2
NCBI Official Synonym Symbols
Hbp; STAM2A; STAM2B
UniProt Protein Name
Signal transducing adapter molecule 2
UniProt Synonym Protein Names
Hrs-binding protein
UniProt Gene Name
STAM2
UniProt Synonym Gene Names
HBP; STAM-2
NCBI Protein Information
signal transducing adapter molecule 2

NCBI Summary for STAM2

The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation. [provided by RefSeq, Jul 2008]
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UniProt Comments for STAM2

Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes ().
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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