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p62 DOK Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS858684

MBS858684 is an antibody targeting p62 Dok. Also known as p62 Dok (Phospho-Tyr362) Antibody. Reactive in Human, Mouse, Rat. More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
p62 Dok, Antibody
Full Product Name
p62 Dok (Phospho-Tyr362) Antibody
Product Gene Name
Product Synonym Names
DOK1 Docking protein 1
Species Reactivity
Human, Mouse, Rat
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Specificity
p62Dok (Phospho-Tyr362) antibody detects endogenous levels of p62Dok only when phosphorylated at tyrosine 362.
Preparation and Storage
Store at-20 degree C for 1 year
Molecular Weight
37,405 Da
OMIM
602919
3D Structure
ModBase 3D Structure for Q99704
Immunogen
The antiserum was produced against synthesized phosphopeptide derived from human p62Dok around the phosphorylation site of tyrosine 362 (P-I-YP-D-E).
All Sites
Human: Tyr362
Mouse: Tyr361
Rat: Tyr436
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-p62 Dok antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-p62 Dok antibody
WB: 1:500-1:1000
ELISA: 1:10000

Western Blot (WB) of anti-p62 Dok antibody

Western blot analysis of extracts from JK cells, using p62Dok (Ab-362) antibody (Line 1 and 2) and p62Dok (Phospho-Tyr362) antibody (Line 3 and 4).
Anti-p62 DOK Antibody – Cat# MBS858684

Product References and Citations for anti-p62 Dok antibody

Zhou Songyang, et, al. (2001) J. Biol. Chem; 276: 2459-2465. Jean-Guy Némorin, et, al.(2000) J. Biol. Chem; 275: 14590. Yuji Yamanashi, et, al.(2000) Genes & Dev; 14: 11. Ibuki Kato, et, al.(2002) J. Immunol; 168: 629.

Other Notes

Small volumes of anti-p62 Dok antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for p62 Dok. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
docking protein 1 isoform b
NCBI Official Synonym Full Names
docking protein 1
NCBI Official Symbol
DOK1
NCBI Official Synonym Symbols
pp62; P62DOK
UniProt Protein Name
Docking protein 1
UniProt Synonym Protein Names
Downstream of tyrosine kinase 1; p62(dok); pp62
UniProt Gene Name
DOK1
NCBI Protein Information
docking protein 1

NCBI Summary for p62 Dok

The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
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UniProt Comments for p62 Dok

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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