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Cyclin E2 (CYCE2) Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS859001

MBS859001 is an antibody targeting CYCE2. Also known as Cyclin E2 (Ab-392) Antibody. Reactive in Human, Mouse. More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Cyclin E2 (CYCE2), Antibody
Full Product Name
Cyclin E2 (Ab-392) Antibody
Product Gene Name
anti-CYCE2 antibody
Product Synonym Names
CGE2; cyclin E2; G1/S-Specific cyclin E2
Species Reactivity
Human, Mouse
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Specificity
Cyclin E2 (Ab-392) antibody detects endogenous levels of total Cyclin E2 protein.
Preparation and Storage
Store at-20 degree C for 1 year.
Molecular Weight
41,465 Da
OMIM
603775
3D Structure
ModBase 3D Structure for O96020
Immunogen
The antiserum was produced against synthesized non-phosphopeptide derived from human Cyclin E2 around the phosphorylation site of threonine 392 (I-M-TP-P-P).

Product Categories/Family for anti-CYCE2 antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-CYCE2 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)
Application Notes for anti-CYCE2 antibody
WB: 1:500~1:1000
IHC: 1:50~1:100
IF: 1:100~1:500
ELISA: 1:10000

Testing Data of anti-CYCE2 antibody

Peptide-+
Anti-CYCE2 Antibody – Cat# MBS859001

Immunohistochemistry (IHC) of anti-CYCE2 antibody

Immunohistochemistry analysis of paraffin-embedded human thyroid gland tissue using Cyclin E2 (Ab-392) antibody. Western blot analysis of extracts from COLO cells and Jurkat cells, using Cyclin E2 (Ab-392) antibody.
Anti-CYCE2 Antibody, Immunohistochemistry (IHC) – Cat# MBS859001

Immunofluorescence (IF) of anti-CYCE2 antibody

Peptide-+ Immunofluorescence analysis of NIH/3T3 cells, using Cyclin E2 (Ab-392) antibody.
Anti-CYCE2 Antibody, Immunofluorescence (IF) – Cat# MBS859001

Product References and Citations for anti-CYCE2 antibody

Gudas J.M., Mol. Cell. Biol. 19:612-622(1999). Lauper N., Oncogene 17:2637-2643(1998). Zariwala M., Oncogene 17:2787-2798(1998).

Other Notes

Small volumes of anti-CYCE2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CYCE2. It may not necessarily be applicable to this product.

NCBI GI #
17318565
NCBI GeneID
9134
NCBI Accession #
NP_477097.1
UniProt Primary Accession #
O96020
UniProt Secondary Accession #
O95439
UniProt Related Accession #
O96020
GenBank Nucleotide #
NM_057749.2
NCBI Official Full Name
G1/S-specific cyclin-E2
NCBI Official Synonym Full Names
cyclin E2
NCBI Official Symbol
CCNE2
NCBI Official Synonym Symbols
CYCE2
UniProt Protein Name
G1/S-specific cyclin-E2
Protein Family
G1/S-specific cyclin
UniProt Gene Name
CCNE2
NCBI Protein Information
G1/S-specific cyclin-E2

NCBI Summary for CYCE2

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells. [provided by RefSeq, Jul 2008]
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UniProt Comments for CYCE2

Essential for the control of the cell cycle at the late G1 and early S phase.

Research Articles on CYCE2

1. Combinatorial PX-866 and Raloxifene Decrease Rb Phosphorylation, Cyclin E2 Transcription, and Proliferation of MCF-7 Breast Cancer Cells

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CYCE2 antibody

 Reference Product  PubMed Publications
 CDK2 antibody  >16 publications with CYCE2 and CDK2
 CDKN1A antibody  >14 publications with CYCE2 and CDKN1A
 CDKN1B antibody  >6 publications with CYCE2 and CDKN1B
 CDK3 antibody  >2 publications with CYCE2 and CDK3
 CDKN1C antibody  >1 publications with CYCE2 and CDKN1C

Pathways associated with anti-CYCE2 antibody

 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Checkpoints Pathway antibodies  Cell Cycle Checkpoints Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cyclin A:Cdk2-associated Events At S Phase Entry Pathway antibodies  Cyclin A:Cdk2-associated Events At S Phase Entry Pathway Diagram
 Cyclin E Associated Events During G1/S Transition Pathway antibodies  Cyclin E Associated Events During G1/S Transition Pathway Diagram
 DNA Damage Response Pathway antibodies  DNA Damage Response Pathway Diagram
 E2F Transcription Factor Network Pathway antibodies  E2F Transcription Factor Network Pathway Diagram

Diseases associated with anti-CYCE2 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >45 publications with CYCE2 and Neoplasms
 Breast Neoplasms Antibodies  >13 publications with CYCE2 and Breast Neoplasms
 Carcinoma Antibodies  >9 publications with CYCE2 and Carcinoma
 Cell Transformation, Neoplastic Antibodies  >6 publications with CYCE2 and Cell Transformation, Neoplastic
 Neoplasm Metastasis Antibodies  >5 publications with CYCE2 and Neoplasm Metastasis
 Skin Neoplasms Antibodies  >4 publications with CYCE2 and Skin Neoplasms
 Ovarian Neoplasms Antibodies  >4 publications with CYCE2 and Ovarian Neoplasms
 Liver Diseases Antibodies  >3 publications with CYCE2 and Liver Diseases
 Abnormalities, Drug-Induced Antibodies  >3 publications with CYCE2 and Abnormalities, Drug-Induced
 Lung Diseases Antibodies  >3 publications with CYCE2 and Lung Diseases

Organs/Tissues associated with anti-CYCE2 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >7 publications with CYCE2 and Liver
 Skin Antibodies  >4 publications with CYCE2 and Skin
 Ovary Antibodies  >4 publications with CYCE2 and Ovary
 Muscle Antibodies  >3 publications with CYCE2 and Muscle
 Prostate Antibodies  >3 publications with CYCE2 and Prostate
 Lung Antibodies  >3 publications with CYCE2 and Lung
 Embryonic Tissue Antibodies  >2 publications with CYCE2 and Embryonic Tissue
 Lymph Node Antibodies  >2 publications with CYCE2 and Lymph Node
 Uterus Antibodies  >1 publications with CYCE2 and Uterus
 Placenta Antibodies  >1 publications with CYCE2 and Placenta
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