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MLK3 Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS859059

MBS859059 is an antibody targeting MLK3. Also known as MLK3 (Ab-674) Antibody. Reactive in Human, Mouse, Rat. More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MLK3, Antibody
Full Product Name
MLK3 (Ab-674) Antibody
Product Gene Name
anti-MLK3 antibody
Product Synonym Names
EC 2.7.11.25; kinase MLK3; M3K11; MAP3K11; MAPKKK11; mitogen activated protein kinase kinase kinase 11; mixed lineage kinase 3; MLK-3; Similar to mitogen-activated protein kinase kinase kinase 11; SPRK
Species Reactivity
Human, Mouse, Rat
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Specificity
MLK3 antibody detects endogenous levels of total MLK3 protein.
Preparation and Storage
Store at-20 degree C for 1 year.
Molecular Weight
65,344 Da
OMIM
600050
3D Structure
ModBase 3D Structure for Q16584
Immunogen
The antiserum was produced against synthesized peptide derived from Internal of human MLK3.

Product Categories/Family for anti-MLK3 antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-MLK3 antibody
Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-MLK3 antibody
IHC: 1:50-1:100
ELISA: 1:20000

Immunohistochemistry (IHC) of anti-MLK3 antibody

Peptide-+ Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using MLK3 antibody.
Anti-MLK3 Antibody – Cat# MBS859059

Product References and Citations for anti-MLK3 antibody

Gallo K.A., J. Biol. Chem. 269:15092-15100(1994). Ing Y.L., Oncogene 9:1745-1750(1994). Leung I.W.L., J. Biol. Chem. 273:32408-32415(1998).

Other Notes

Small volumes of anti-MLK3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MLK3. It may not necessarily be applicable to this product.

NCBI GI #
4505195
NCBI GeneID
4296
NCBI Accession #
NP_002410.1
UniProt Primary Accession #
Q16584
UniProt Secondary Accession #
Q53H00; Q59F06; Q6P2G4; B4DS76
UniProt Related Accession #
Q16584
GenBank Nucleotide #
NM_002419.3
NCBI Official Full Name
mitogen-activated protein kinase kinase kinase 11
NCBI Official Synonym Full Names
mitogen-activated protein kinase kinase kinase 11
NCBI Official Symbol
MAP3K11
NCBI Official Synonym Symbols
MLK3; PTK1; SPRK; MLK-3; MEKK11
UniProt Protein Name
Mitogen-activated protein kinase kinase kinase 11
UniProt Synonym Protein Names
Mixed lineage kinase 3; Src-homology 3 domain-containing proline-rich kinase
UniProt Gene Name
MAP3K11
NCBI Protein Information
mitogen-activated protein kinase kinase kinase 11

NCBI Summary for MLK3

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008]
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UniProt Comments for MLK3

Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle.
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Research Articles on MLK3

1. In summary, this investigation identifies an EGFR-DOCK180-RAC1-MLK3-JNK signaling axis that drives glioblastoma cell migration and dissemination.IMPLICATIONS: On the basis of these findings, MLK3 emerges as a potential therapeutic target for the treatment of glioblastoma

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MLK3 antibody

 Reference Product  PubMed Publications
 MAP3K1 antibody  >1 publications with MLK3 and MAP3K1

Pathways associated with anti-MLK3 antibody

 Products by Pathway  Pathway Diagram
 CDC42 Signaling Events Pathway antibodies  CDC42 Signaling Events Pathway Diagram
 IFN-gamma Pathway antibodies  IFN-gamma Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Non-alcoholic Fatty Liver Disease (NAFLD) Pathway antibodies  Non-alcoholic Fatty Liver Disease (NAFLD) Pathway Diagram
 Non-alcoholic Fatty Liver Disease (NAFLD) Pathway antibodies  Non-alcoholic Fatty Liver Disease (NAFLD) Pathway Diagram
 RAC1 Signaling Pathway antibodies  RAC1 Signaling Pathway Diagram
 Reelin Signaling Pathway antibodies  Reelin Signaling Pathway Diagram

Diseases associated with anti-MLK3 antibody

 Disease Name  Pubmed Publications
 Hearing Loss Antibodies  >1 publications with MLK3 and Hearing Loss
 Nervous System Diseases Antibodies  >1 publications with MLK3 and Nervous System Diseases
 Immune System Diseases Antibodies  >1 publications with MLK3 and Immune System Diseases
 Breast Neoplasms Antibodies  >1 publications with MLK3 and Breast Neoplasms
 Inflammation Antibodies  >1 publications with MLK3 and Inflammation

Organs/Tissues associated with anti-MLK3 antibody

 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >3 publications with MLK3 and Testis
 Blood Antibodies  >1 publications with MLK3 and Blood
 Adrenal Gland Antibodies  >1 publications with MLK3 and Adrenal Gland
 Uterus Antibodies  >1 publications with MLK3 and Uterus
 Prostate Antibodies  >1 publications with MLK3 and Prostate
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