P-peptide-+ Immunohistochemistry analysis of paraffin-embedded human brain tissue using Kv7.3/KCNQ3 (Phospho-Thr246) antibody.

KV7.3/KCNQ3 Antibody

Name: KV7.3/KCNQ3 Antibody; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS859281
Price: 380 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS859281

MBS859281 is an antibody targeting Kv7.3/KCNQ3. Also known as Kv7.3/KCNQ3 (Phospho-Thr246) Antibody. Reactive in Human, Mouse, Rat. More details

$380 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Kv7.3/KCNQ3, Antibody

Full Product Name

Kv7.3/KCNQ3 (Phospho-Thr246) Antibody

Product Gene Name

anti-Kv7.3/KCNQ3 antibody

Product Synonym Names

KCNQ3; KQT-like 3; potassium channel alpha subunit KvLQT3; potassium voltage-gated channel subfamily KQT member 3; voltage-gated potassium channel subunit Kv7.3

Species Reactivity

Human, Mouse, Rat

Form/Format

In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Purity/Purification

Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.

Specificity

Kv7.3/KCNQ3 (Phospho-Thr246) antibody detects endogenous levels of Kv7.3/KCNQ3 only when phosphorylated at threonine 246.

Preparation and Storage

Store at-20 degree C for 1 year.

Molecular Weight

84,804 Da

OMIM

121201

3D Structure

ModBase 3D Structure for O43525

Immunogen

The antiserum was produced against synthesized phosphopeptide derived from human Kv7.3/KCNQ3 around the phosphorylation site of threonine 246 (G-G-TP-W-K).

All Sites

Human: Thr246
Mouse: Thr247
Rat: Thr247

Product Categories/Family for anti-Kv7.3/KCNQ3 antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for anti-Kv7.3/KCNQ3 antibody

Immunohistochemistry (IHC), ELISA (EIA)

Application Notes for anti-Kv7.3/KCNQ3 antibody

IHC: 1:50-1:100
ELISA: 1:20000

Product References and Citations for anti-Kv7.3/KCNQ3 antibody

Schroeder B.C., Nature 396:687-690(1998). Charlier C., Nat. Genet. 18:53-55(1998). Yang W.-P., J. Biol. Chem. 273:19419-19423(1998).

Other Notes

Small volumes of anti-Kv7.3/KCNQ3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Kv7.3/KCNQ3. It may not necessarily be applicable to this product.

NCBI GI #

325651930

NCBI GeneID

3786

NCBI Accession #

NP_001191753.1

UniProt Primary Accession #

O43525

UniProt Secondary Accession #

A2VCT8; B4DJY4; E7EQ89

UniProt Related Accession #

O43525

GenBank Nucleotide #

NM_001204824.1

NCBI Official Full Name

potassium voltage-gated channel subfamily KQT member 3 isoform 2

NCBI Official Synonym Full Names

potassium voltage-gated channel subfamily Q member 3

NCBI Official Symbol

KCNQ3

NCBI Official Synonym Symbols

EBN2; BFNC2; KV7.3

UniProt Protein Name

Potassium voltage-gated channel subfamily KQT member 3

UniProt Synonym Protein Names

KQT-like 3; Potassium channel subunit alpha KvLQT3; Voltage-gated potassium channel subunit Kv7.3

UniProt Gene Name

KCNQ3

NCBI Protein Information

potassium voltage-gated channel subfamily KQT member 3

NCBI Summary for Kv7.3/KCNQ3

This gene encodes a protein that functions in the regulation of neuronal excitability. The encoded protein forms an M-channel by associating with the products of the related KCNQ2 or KCNQ5 genes, which both encode integral membrane proteins. M-channel currents are inhibited by M1 muscarinic acetylcholine receptors and are activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 2 (BFNC2), also known as epilepsy, benign neonatal type 2 (EBN2). Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]

UniProt Comments for Kv7.3/KCNQ3

Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability.

Research Articles on Kv7.3/KCNQ3

1. In the present work, a pharmacophore-based 3D-QSAR model was generated for a series of N-pyridyl and pyrimidine benzamides possessing KCNQ2/Q3 opening activity. The pharmacophore model generated contains one hydrogen bond donor (D), one hydrophobic (H), and two aromatic rings (R). They are the crucial molecular write-up detailing predicted binding efficacy of high affinity and low affinity ligands for KCNQ2/Q3 opening a

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Kv7.3/KCNQ3 antibody

Reference Product	PubMed Publications
KCNQ2 antibody	>233 publications with Kv7.3/KCNQ3 and KCNQ2
KCNQ5 antibody	>47 publications with Kv7.3/KCNQ3 and KCNQ5
KCNQ4 antibody	>38 publications with Kv7.3/KCNQ3 and KCNQ4

Pathways associated with anti-Kv7.3/KCNQ3 antibody

Products by Pathway	Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Cholinergic Synapse Pathway antibodies	Cholinergic Synapse Pathway Diagram
Developmental Biology Pathway antibodies	Developmental Biology Pathway Diagram
Interaction Between L1 And Ankyrins Pathway antibodies	Interaction Between L1 And Ankyrins Pathway Diagram
L1CAM Interactions Pathway antibodies	L1CAM Interactions Pathway Diagram
Neuronal System Pathway antibodies	Neuronal System Pathway Diagram
Potassium Channels Pathway antibodies	Potassium Channels Pathway Diagram
Voltage Gated Potassium Channels Pathway antibodies	Voltage Gated Potassium Channels Pathway Diagram

Diseases associated with anti-Kv7.3/KCNQ3 antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>113 publications with Kv7.3/KCNQ3 and Nervous System Diseases
Epilepsy, Benign Neonatal Antibodies	>84 publications with Kv7.3/KCNQ3 and Epilepsy, Benign Neonatal
Seizures Antibodies	>70 publications with Kv7.3/KCNQ3 and Seizures
Pain Antibodies	>19 publications with Kv7.3/KCNQ3 and Pain
Long QT Syndrome Antibodies	>9 publications with Kv7.3/KCNQ3 and Long QT Syndrome
Arrhythmias, Cardiac Antibodies	>5 publications with Kv7.3/KCNQ3 and Arrhythmias, Cardiac
Migraine Disorders Antibodies	>5 publications with Kv7.3/KCNQ3 and Migraine Disorders
Chromosome Aberrations Antibodies	>3 publications with Kv7.3/KCNQ3 and Chromosome Aberrations
Dizziness Antibodies	>1 publications with Kv7.3/KCNQ3 and Dizziness
Fibrosis Antibodies	>1 publications with Kv7.3/KCNQ3 and Fibrosis

Organs/Tissues associated with anti-Kv7.3/KCNQ3 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>76 publications with Kv7.3/KCNQ3 and Brain
Muscle Antibodies	>20 publications with Kv7.3/KCNQ3 and Muscle
Kidney Antibodies	>11 publications with Kv7.3/KCNQ3 and Kidney
Blood Antibodies	>8 publications with Kv7.3/KCNQ3 and Blood
Vascular Antibodies	>6 publications with Kv7.3/KCNQ3 and Vascular
Liver Antibodies	>2 publications with Kv7.3/KCNQ3 and Liver
Intestine Antibodies	>2 publications with Kv7.3/KCNQ3 and Intestine
Embryonic Tissue Antibodies	>2 publications with Kv7.3/KCNQ3 and Embryonic Tissue
Uterus Antibodies	>1 publications with Kv7.3/KCNQ3 and Uterus
Eye Antibodies	>1 publications with Kv7.3/KCNQ3 and Eye