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14-3-3 zeta Antibody

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS859975

MBS859975 is an antibody targeting 14-3-3 zeta. Also known as 14-3-3 zeta (Ab-58) Antibody. Reactive in Human, Mouse, Rat. More details

$380 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
14-3-3 zeta, Antibody
Full Product Name
14-3-3 zeta (Ab-58) Antibody
Product Gene Name
anti-14-3-3 zeta antibody
Product Synonym Names
14-3-3 protein zeta/delta; 1433Z; 143Z; FAS; Factor activating exoenzyme S; KCIP-1; Mitochondrial import stimulation factor S1 subunit; Protein kinase C inhibitor protein-1; YWHAZ
Species Reactivity
Human, Mouse, Rat
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Specificity
14-3-3 zeta (Ab-58) antibody detects endogenous levels of total 14-3-3 zeta protein.
Preparation and Storage
Store at-20 degree C for 1 year
Molecular Weight
19,333 Da
OMIM
601288
3D Structure
ModBase 3D Structure for P63104
Immunogen
The antiserum was produced against synthesized non-phosphopeptide derived from human 14-3-3 zeta around the phosphorylation site of serine 58 (R-S-SP-W-R).

Product Categories/Family for anti-14-3-3 zeta antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-14-3-3 zeta antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF), ELISA (EIA)
Application Notes for anti-14-3-3 zeta antibody
WB: 1:500~1000
IHC: 1:50~100
IF: 1:100~1:500
ELISA: 1:40000

Immunohistochemistry (IHC) of anti-14-3-3 zeta antibody

Peptide-+ Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using 14-3-3 zeta (Ab-58) antibody.
Anti-14-3-3 zeta Antibody – Cat# MBS859975

Western Blot (WB) of anti-14-3-3 zeta antibody

Western blot analysis of extracts from 293 cells treated with Forskolin (40nM, 30min) using 14-3-3 zeta (Ab-58) antibody.
Anti-14-3-3 zeta Antibody, Western Blot (WB) – Cat# MBS859975

Immunofluorescence (IF) of anti-14-3-3 zeta antibody

PMA +- Immunofluorescence analysis of HeLa cells, treated with PMA (125ng/ml, 30mins), using 14-3-3 zeta (Ab-58) antibody.
Anti-14-3-3 zeta Antibody, Immunofluorescence (IF) – Cat# MBS859975

Product References and Citations for anti-14-3-3 zeta antibody

Ying H. Shen Mol. Biol. Cell, Nov 2003; 14: 4721. David W. Powell, Mol. Cell. Biol., Aug 2003; 23: 5376-5387. Mackintosh. C, (2004) Biochem. J. 381, 329-42. Dougherty, M.K. and Morrison, D.K. (2004) J. Cell Sci. 117, 1875-84.

Other Notes

Small volumes of anti-14-3-3 zeta antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for 14-3-3 zeta. It may not necessarily be applicable to this product.

NCBI GI #
208973238
NCBI GeneID
7534
NCBI Accession #
NP_001129171.1
UniProt Primary Accession #
P63104
UniProt Secondary Accession #
P29213; P29312; Q32P43; Q5XJ08; Q6GPI2; Q6IN74; Q6NUR9; Q6P3U9; Q86V33; A8K1N0; B7Z465
UniProt Related Accession #
P63104
GenBank Nucleotide #
NM_001135699.1
NCBI Official Full Name
14-3-3 protein zeta/delta
NCBI Official Synonym Full Names
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
NCBI Official Symbol
YWHAZ
NCBI Official Synonym Symbols
HEL4; YWHAD; KCIP-1; HEL-S-3; HEL-S-93; 14-3-3-zeta
UniProt Protein Name
14-3-3 protein zeta/delta
UniProt Synonym Protein Names
Protein kinase C inhibitor protein 1; KCIP-1
Protein Family
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
UniProt Gene Name
YWHAZ
UniProt Synonym Gene Names
KCIP-1
NCBI Protein Information
14-3-3 protein zeta/delta

NCBI Summary for 14-3-3 zeta

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq, Oct 2008]
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UniProt Comments for 14-3-3 zeta

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
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Research Articles on 14-3-3 zeta

1. Dimerization of 14-3-3 zeta (14-3-3zeta) dimer was disrupted by a double mutant (L12E, M78K).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-14-3-3 zeta antibody

 Reference Product  PubMed Publications
 TUBB antibody  >4 publications with 14-3-3 zeta and TUBB
 YWHAE antibody  >3 publications with 14-3-3 zeta and YWHAE
 BCR antibody  >2 publications with 14-3-3 zeta and BCR
 VIM antibody  >2 publications with 14-3-3 zeta and VIM
 LIMK1 antibody  >1 publications with 14-3-3 zeta and LIMK1
 IRS1 antibody  >1 publications with 14-3-3 zeta and IRS1
 FOXO3 antibody  >1 publications with 14-3-3 zeta and FOXO3
 EGFR antibody  >1 publications with 14-3-3 zeta and EGFR
 CFL1 antibody  >1 publications with 14-3-3 zeta and CFL1
 ABL1 antibody  >1 publications with 14-3-3 zeta and ABL1

Pathways associated with anti-14-3-3 zeta antibody

 Products by Pathway  Pathway Diagram
 Activation Of BAD And Translocation To Mitochondria Pathway antibodies  Activation Of BAD And Translocation To Mitochondria Pathway Diagram
 Activation Of BH3-only Proteins Pathway antibodies  Activation Of BH3-only Proteins Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Class I PI3K Signaling Events Mediated By Akt Pathway antibodies  Class I PI3K Signaling Events Mediated By Akt Pathway Diagram

Diseases associated with anti-14-3-3 zeta antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >28 publications with 14-3-3 zeta and Neoplasms
 Carcinoma Antibodies  >12 publications with 14-3-3 zeta and Carcinoma
 Brain Diseases Antibodies  >10 publications with 14-3-3 zeta and Brain Diseases
 Nervous System Diseases Antibodies  >9 publications with 14-3-3 zeta and Nervous System Diseases
 Breast Neoplasms Antibodies  >7 publications with 14-3-3 zeta and Breast Neoplasms
 Skin Diseases Antibodies  >7 publications with 14-3-3 zeta and Skin Diseases
 Cardiovascular Diseases Antibodies  >6 publications with 14-3-3 zeta and Cardiovascular Diseases
 Inflammation Antibodies  >5 publications with 14-3-3 zeta and Inflammation
 Heart Diseases Antibodies  >4 publications with 14-3-3 zeta and Heart Diseases
 Drug Toxicity Antibodies  >3 publications with 14-3-3 zeta and Drug Toxicity

Organs/Tissues associated with anti-14-3-3 zeta antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >21 publications with 14-3-3 zeta and Brain
 Blood Antibodies  >18 publications with 14-3-3 zeta and Blood
 Liver Antibodies  >13 publications with 14-3-3 zeta and Liver
 Muscle Antibodies  >10 publications with 14-3-3 zeta and Muscle
 Heart Antibodies  >8 publications with 14-3-3 zeta and Heart
 Lung Antibodies  >6 publications with 14-3-3 zeta and Lung
 Kidney Antibodies  >5 publications with 14-3-3 zeta and Kidney
 Prostate Antibodies  >4 publications with 14-3-3 zeta and Prostate
 Stomach Antibodies  >4 publications with 14-3-3 zeta and Stomach
 Embryonic Tissue Antibodies  >4 publications with 14-3-3 zeta and Embryonic Tissue
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