Nuclear Receptor Interacting Protein 1 (NRIP1) ELISA Kit for Bovine

RIP140: Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Interacts with RARA and RXRB homodimers and RARA/RXRB heterodimers in the presence of ligand. Interacts with HDAC1 and HDAC3 via its N-terminal domain. Interacts with NR2C1 (sumoylated form and via the ligand-binding domain); the interaction results in promoting the repressor activity of NR2C1. Interacts with CTBP1, CTBP2, ESR1, HDAC1, HDAC2, HDAC5, HDAC6, NR2C2, NR3C1, NR3C2, YWHAH, JUN and FOS. Found in a complex with both NR3C1 and YWHAH. Interacts with ZNF366.

Protein type: Transcription, coactivator/corepressor; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 21q11.2

Cellular Component: nucleoplasm; histone deacetylase complex; nucleolus; nuclear speck; nucleus; cell junction

Molecular Function: retinoid X receptor binding; protein binding; androgen receptor binding; histone deacetylase binding; transcription coactivator activity; estrogen receptor binding; transcription corepressor activity; glucocorticoid receptor binding; nuclear hormone receptor binding

Biological Process: circadian rhythm; sequestering of lipid; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; circadian regulation of gene expression; ovarian follicle rupture