Islet Amyloid Poly (IAPP) ELISA Kit for Cat

Name: Cat IAPP ELISA Kit; Islet Amyloid Poly; MyBioSource
Brand: MyBioSource
SKU: MBS089235
Price: 675 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS089235

Background: This Quantitative Sandwich ELISA kit is for lab reagent/research use only, not for drug, household, therapeutic or test applications! This kit is intended to be used to determine the level of IAPP (hereafter termed "analyte") in undiluted original… More details

$675 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Request Current Manual

Product Overview

Online Datasheet in PDF

Product Name

Islet Amyloid Polypeptide (IAPP), ELISA Kit

Full Product Name

Cat Islet Amyloid Polypeptide ELISA Kit

Product Gene Name

IAPP elisa kit

Species Reactivity

Cat

Assay Type

Quantitative Sandwich

Detection Range

0.25umol/L-8umol/L

Sensitivity

0.1umol/L

Preparation and Storage

Store all reagents at 2-8 degree C

Inter-assay Precision

Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100]. All CV% should be compared by concentration, not compared by OD values.

Intra-assay Precision

Intra-assay CV (%) is less than 15%.

Molecular Weight

9,806 Da

Chromosome Location

Chromosome: 12; NC_000012.11 (21525802..21532914). Location: 12p12.1

OMIM

147940

3D Structure

ModBase 3D Structure for P10997

Other Notes

Small volumes of IAPP elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IAPP purchase

MBS089235 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Islet Amyloid Polypeptide (IAPP) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing IAPP. The ELISA analytical biochemical technique of the MBS089235 kit is based on IAPP antibody-IAPP antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect IAPP antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, IAPP. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for IAPP. It may not necessarily be applicable to this product.

NCBI GI #

4557655

NCBI GeneID

3375

NCBI Accession #

NP_000406.1

UniProt Primary Accession #

P10997

UniProt Secondary Accession #

Q0ZD87; Q14598

UniProt Related Accession #

P10997

GenBank Nucleotide #

NM_000415.2

NCBI Official Full Name

islet amyloid polypeptide

NCBI Official Synonym Full Names

islet amyloid polypeptide

NCBI Official Symbol

IAPP

NCBI Official Synonym Symbols

DAP; IAP

UniProt Protein Name

Islet amyloid polypeptide

UniProt Synonym Protein Names

Amylin; Diabetes-associated peptide; DAP; Insulinoma amyloid peptide

Protein Family

Islet amyloid polypeptide

UniProt Gene Name

IAPP

UniProt Synonym Gene Names

DAP

UniProt Entry Name

IAPP_HUMAN

NCBI Protein Information

islet amyloid polypeptide; amylin; insulinoma amyloid peptide; diabetes-associated peptide; Islet amyloid polypeptide (diabetes-associated peptide; amylin)

NCBI Summary for IAPP

Islet, or insulinoma, amyloid polypeptide is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. While the association of amylin with the development of type II diabetes has been known for some time, a direct causative role for amylin has been harder to establish. Studies suggest that amylin, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes. [provided by RefSeq, Apr 2011]

UniProt Comments for IAPP

IAPP: Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. Belongs to the calcitonin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12p12.1

Cellular Component: extracellular space; cell soma; extracellular region

Molecular Function: identical protein binding; hormone activity; receptor binding

Biological Process: negative regulation of cell differentiation; cell-cell signaling; eating behavior; apoptosis; sensory perception of pain; signal transduction; negative regulation of bone resorption; endocrine pancreas development

Research Articles on IAPP

1. the presence of Ca(2+) ions inhibits membrane damage occurring immediately after the interaction of freshly dissolved hIAPP with the membrane.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IAPP elisa kit

Reference Product	PubMed Publications
INS elisa kit	>33 publications with IAPP and INS
SCT elisa kit	>29 publications with IAPP and SCT
RAMP3 elisa kit	>17 publications with IAPP and RAMP3
TTR elisa kit	>4 publications with IAPP and TTR
ADM elisa kit	>3 publications with IAPP and ADM
GCG elisa kit	>3 publications with IAPP and GCG
CALCA elisa kit	>1 publications with IAPP and CALCA
CALCR elisa kit	>1 publications with IAPP and CALCR

Pathways associated with IAPP elisa kit

Products by Pathway	Pathway Diagram
Amyloids Pathway antibodies	Amyloids Pathway Diagram
Calcitonin-like Ligand Receptors Pathway antibodies	Calcitonin-like Ligand Receptors Pathway Diagram
Class B/2 (Secretin Family Receptors) Pathway antibodies	Class B/2 (Secretin Family Receptors) Pathway Diagram
Developmental Biology Pathway antibodies	Developmental Biology Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
G Alpha (s) Signalling Events Pathway antibodies	G Alpha (s) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
Integrated Pancreatic Cancer Pathway antibodies	Integrated Pancreatic Cancer Pathway Diagram
Maturity Onset Diabetes Of The Young Pathway antibodies	Maturity Onset Diabetes Of The Young Pathway Diagram

Diseases associated with IAPP elisa kit

Disease Name	Pubmed Publications
Diabetes Mellitus Antibodies	>841 publications with IAPP and Diabetes Mellitus
Diabetes Mellitus, Type 2 Antibodies	>547 publications with IAPP and Diabetes Mellitus, Type 2
Hyperglycemia Antibodies	>162 publications with IAPP and Hyperglycemia
Hyperinsulinism Antibodies	>108 publications with IAPP and Hyperinsulinism
Diabetes Mellitus, Experimental Antibodies	>80 publications with IAPP and Diabetes Mellitus, Experimental
Drug Toxicity Antibodies	>76 publications with IAPP and Drug Toxicity
Ulcer Antibodies	>51 publications with IAPP and Ulcer
Hypertension Antibodies	>34 publications with IAPP and Hypertension
Inflammation Antibodies	>26 publications with IAPP and Inflammation
Kidney Diseases Antibodies	>19 publications with IAPP and Kidney Diseases

Organs/Tissues associated with IAPP elisa kit

Organ/Tissue Name	Pubmed Publications
Pancreas Antibodies	>748 publications with IAPP and Pancreas
Connective Tissue Antibodies	>38 publications with IAPP and Connective Tissue
Mixed Antibodies	>34 publications with IAPP and Mixed
Testis Antibodies	>1 publications with IAPP and Testis