Human SERPING1 ELISA Kit – Cat# MBS901594

Serpin Peptidase Inhibitor, Clade G (C1 Inhibitor), Member 1 (SERPING1) ELISA Kit for Human

Name: Human SERPING1 ELISA Kit; MyBioSource
Brand: MyBioSource
SKU: MBS901594
Price: 295 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS901594

Principle of the Assay: This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with SERPING1. Standards or samples are added to the appropriate microtiter plate wells with… More details

$295 / 24-Strip-Wells (LIMIT 1) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

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Product Overview

Online Datasheet in PDF

Product Name

serpin peptidase inhibitor, clade G (C1 inhibitor) , member 1 (SERPING1), ELISA Kit

Full Product Name

Human Plasma protease C1 inhibitor, SERPING1 ELISA Kit

Product Gene Name

SERPING1 elisa kit

Product Synonym Names

Human Plasma protease C1 inhibitor (SERPING1) ELISA kit; C1IN; C1INH; C1NH; HAE1; HAE2; complement component 1 inhibitor; plasma protease C1 inhibitor; serine/cysteine proteinase inhibitor clade G member 1; serpin peptidase inhibitor; clade G; member 1; serpin peptidase inhibitor; clade G (C1 inhibitor); member 1

Species Reactivity

Human

Assay Type

Quantitative Competitive

Samples

Serum, plasma, tissue homogenates.

Sensitivity

Typically less than 4.7 ng/ml.

Specificity

This assay has high sensitivity and excellent specificity for detection of human SERPING1. No significant cross-reactivity or interference between human SERPING1 and analogues was observed.

Preparation and Storage

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

Inter-assay Precision

Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.

Intra-assay Precision

Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess.

Molecular Weight

55,154 Da

OMIM

606860

3D Structure

ModBase 3D Structure for P05155

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of SERPING1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SERPING1 purchase

MBS901594 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 (SERPING1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing SERPING1. The ELISA analytical biochemical technique of the MBS901594 kit is based on SERPING1 antibody-SERPING1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect SERPING1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, SERPING1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for SERPING1. It may not necessarily be applicable to this product.

NCBI GI #

73858568

NCBI GeneID

710

NCBI Accession #

NP_000053.2

UniProt Primary Accession #

P05155

UniProt Secondary Accession #

Q16304; Q547W3; Q59EI5; Q7Z455; Q96FE0; Q9UC49; Q9UCF9; A6NMU0; A8KAI9; B2R6L5

UniProt Related Accession #

P05155

GenBank Nucleotide #

NM_000062.2

NCBI Official Full Name

plasma protease C1 inhibitor

NCBI Official Synonym Full Names

serpin peptidase inhibitor, clade G (C1 inhibitor), member 1

NCBI Official Symbol

SERPING1

NCBI Official Synonym Symbols

C1IN; C1NH; HAE1; HAE2; C1INH

UniProt Protein Name

Plasma protease C1 inhibitor

UniProt Synonym Protein Names

C1 esterase inhibitor; C1-inhibiting factor; Serpin G1

Protein Family

Plasma protease C1 inhibitor

UniProt Gene Name

SERPING1

UniProt Synonym Gene Names

C1IN; C1NH; C1 Inh; C1Inh

UniProt Entry Name

IC1_HUMAN

NCBI Protein Information

plasma protease C1 inhibitor; serpin G1; C1-inhibiting factor; C1 esterase inhibitor; complement component 1 inhibitor; serine/cysteine proteinase inhibitor clade G member 1

NCBI Summary for SERPING1

This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform. [provided by RefSeq, Jul 2008]

UniProt Comments for SERPING1

SERPING1: a protein protease inhibitor (C1-inhibitor) that forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play an important role in regulating complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Mutations of the SERPING1 gene is associated with adult macular degeneration can also cause hereditary angioedema. Binds to E.coli stcE which allows localization of SERPING1 to cell membranes thus protecting the bacteria against complement-mediated lysis. Belongs to the serpin family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 11q12.1

Cellular Component: extracellular space; extracellular region

Molecular Function: serine-type endopeptidase inhibitor activity; protein binding

Biological Process: negative regulation of complement activation, lectin pathway; platelet activation; fibrinolysis; platelet degranulation; blood circulation; innate immune response; blood coagulation; blood coagulation, intrinsic pathway; complement activation, classical pathway; aging

Disease: Angioedema, Hereditary, Type I; Complement Component 4, Partial Deficiency Of

Research Articles on SERPING1

1. study identified and characterized a new mutation in SERPING1 gene in a Spanish family with hereditary angioedema; the mutation (c.685 + 2 T > A) disrupts the donor splice site of intron 4 leading to the loss of exon 4 in mutant mRNA

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SERPING1 elisa kit

Reference Product	PubMed Publications
C1S elisa kit	>12 publications with SERPING1 and C1S
C1R elisa kit	>7 publications with SERPING1 and C1R
MASP2 elisa kit	>4 publications with SERPING1 and MASP2
MASP1 elisa kit	>2 publications with SERPING1 and MASP1

Pathways associated with SERPING1 elisa kit

Products by Pathway	Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies	Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram
Intrinsic Pathway antibodies	Intrinsic Pathway Diagram
Pertussis Pathway antibodies	Pertussis Pathway Diagram
Pertussis Pathway antibodies	Pertussis Pathway Diagram
Platelet Activation, Signaling And Aggregation Pathway antibodies	Platelet Activation, Signaling And Aggregation Pathway Diagram
Platelet Degranulation Pathway antibodies	Platelet Degranulation Pathway Diagram

Diseases associated with SERPING1 elisa kit

Disease Name	Pubmed Publications
Skin Diseases Antibodies	>113 publications with SERPING1 and Skin Diseases
Angioedemas, Hereditary Antibodies	>56 publications with SERPING1 and Angioedemas, Hereditary
Edema Antibodies	>49 publications with SERPING1 and Edema
Inflammation Antibodies	>18 publications with SERPING1 and Inflammation
Pain Antibodies	>14 publications with SERPING1 and Pain
Neoplasms Antibodies	>9 publications with SERPING1 and Neoplasms
Acquired angioedema Antibodies	>8 publications with SERPING1 and Acquired angioedema
Brain Diseases Antibodies	>7 publications with SERPING1 and Brain Diseases
Disease Models, Animal Antibodies	>7 publications with SERPING1 and Disease Models, Animal
Hereditary Angioedema Types I and II Antibodies	>7 publications with SERPING1 and Hereditary Angioedema Types I and II

Organs/Tissues associated with SERPING1 elisa kit

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>62 publications with SERPING1 and Blood
Vascular Antibodies	>20 publications with SERPING1 and Vascular
Skin Antibodies	>20 publications with SERPING1 and Skin
Larynx Antibodies	>10 publications with SERPING1 and Larynx
Eye Antibodies	>7 publications with SERPING1 and Eye
Heart Antibodies	>5 publications with SERPING1 and Heart
Kidney Antibodies	>4 publications with SERPING1 and Kidney
Intestine Antibodies	>4 publications with SERPING1 and Intestine
Muscle Antibodies	>3 publications with SERPING1 and Muscle
Liver Antibodies	>3 publications with SERPING1 and Liver