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Interferon (Alpha, Beta and Omega) Receptor 2 (IFNAR2) ELISA Kit for Human

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS906140

Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for IFNAR2 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any IFNAR2 present is bound by the… More details

$295 / 24-Strip-Wells (LIMIT 1) +1 FREE 8GB USB

Product Documentation

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
interferon (alpha, beta and omega) receptor 2 (IFNAR2), ELISA Kit
Full Product Name
Human Interferon alpha/beta receptor 2, IFNAR2 ELISA Kit
Product Gene Name
IFNAR2 elisa kit
Product Synonym Names
Human Interferon alpha/beta receptor 2 (IFNAR2) ELISA kit; IFN-R; IFN-alpha-REC; IFNABR; IFNARB; OTTHUMP00000067674; human interferon alpha/beta receptor; interferon alpha/beta receptor 2; interferon-alpha/beta receptor beta chain; type I interferon receptor; interferon (alpha; beta and omega) receptor 2
Species Reactivity
Human
Assay Type
Quantitative Sandwich
Samples
Serum, plasma, tissue homogenates, cell culture supernates
Detection Range
0.156 ng/ml-10 ng/ml
Sensitivity
< 0.039 ng/ml
Specificity
This assay has high sensitivity and excellent specificity for detection of human IFNAR2. No significant cross-reactivity or interference between human IFNAR2 and analogues was observed.
Preparation and Storage
Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
Inter-assay Precision
Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.
Intra-assay Precision
Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess.
Molecular Weight
57,759 Da
OMIM
gene 610424
3D Structure
ModBase 3D Structure for P48551
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Typical Testing Data/Standard Curve (for reference only) of IFNAR2 elisa kit

Human IFNAR2 ELISA Kit – Cat# MBS906140

Other Notes

Small volumes of IFNAR2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IFNAR2 purchase

MBS906140 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the interferon (alpha, beta and omega) receptor 2 (IFNAR2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing IFNAR2. The ELISA analytical biochemical technique of the MBS906140 kit is based on IFNAR2 antibody-IFNAR2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect IFNAR2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, IFNAR2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for IFNAR2. It may not necessarily be applicable to this product.

NCBI GI #
19923129
NCBI GeneID
3455
NCBI Accession #
NP_000865.2
UniProt Primary Accession #
P48551
UniProt Secondary Accession #
Q15467; Q6FHD7; A8KAJ4; D3DSE8; D3DSE9
UniProt Related Accession #
P48551
GenBank Nucleotide #
NM_000874.4
NCBI Official Full Name
interferon alpha/beta receptor 2 isoform b
NCBI Official Synonym Full Names
interferon (alpha, beta and omega) receptor 2
NCBI Official Symbol
IFNAR2
NCBI Official Synonym Symbols
IFN-R; IFNABR; IFNARB; IFN-alpha-REC
UniProt Protein Name
Interferon alpha/beta receptor 2
UniProt Synonym Protein Names
Interferon alpha binding protein; Type I interferon receptor 2
Protein Family
Interferon alpha/beta receptor
UniProt Gene Name
IFNAR2
UniProt Synonym Gene Names
IFNABR; IFNARB; IFN-R-2; IFN-alpha binding protein; IFN-alpha/beta receptor 2
UniProt Entry Name
INAR2_HUMAN
NCBI Protein Information
interferon alpha/beta receptor 2; IFN-R-2; IFN-alpha/beta receptor 2; type I interferon receptor 2; interferon alpha binding protein; human interferon alpha/beta receptor; interferon-alpha/beta receptor beta chain

NCBI Summary for IFNAR2

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for IFNAR2

IFNAR2: Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity. Belongs to the type II cytokine receptor family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 21q22.11

Cellular Component: extracellular space; integral to plasma membrane; extracellular region; plasma membrane

Molecular Function: protein binding; interferon-alpha/beta receptor activity; interferon-alpha/beta binding; protein kinase binding

Biological Process: regulation of transcription from RNA polymerase II promoter; cell proliferation; cell surface receptor linked signal transduction; cytokine and chemokine mediated signaling pathway; response to virus; JAK-STAT cascade

Disease: Hepatitis B Virus, Susceptibility To
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Research Articles on IFNAR2

1. Results suggest that oxidative stress play an important role in the regulation of type I interferon receptors IFNAR1 and IFNAR2 in chronic hepatitis B virus (HBV) infection.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IFNAR2 elisa kit

 Reference Product  PubMed Publications
 IFNA2 elisa kit  >165 publications with IFNAR2 and IFNA2
 IFNAR1 elisa kit  >123 publications with IFNAR2 and IFNAR1
 STAT1 elisa kit  >26 publications with IFNAR2 and STAT1
 STAT2 elisa kit  >22 publications with IFNAR2 and STAT2
 JAK1 elisa kit  >21 publications with IFNAR2 and JAK1
 TYK2 elisa kit  >19 publications with IFNAR2 and TYK2
 STAT3 elisa kit  >11 publications with IFNAR2 and STAT3
 USP18 elisa kit  >4 publications with IFNAR2 and USP18
 IFNB1 elisa kit  >1 publications with IFNAR2 and IFNB1

Pathways associated with IFNAR2 elisa kit

 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Downstream Signaling In Naive CD8+ T Cells Pathway antibodies  Downstream Signaling In Naive CD8+ T Cells Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram

Diseases associated with IFNAR2 elisa kit

 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >22 publications with IFNAR2 and Liver Diseases
 Carcinoma Antibodies  >18 publications with IFNAR2 and Carcinoma
 Adenocarcinoma Antibodies  >14 publications with IFNAR2 and Adenocarcinoma
 Nervous System Diseases Antibodies  >13 publications with IFNAR2 and Nervous System Diseases
 Carcinoma, Hepatocellular Antibodies  >8 publications with IFNAR2 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >7 publications with IFNAR2 and Liver Neoplasms
 Necrosis Antibodies  >7 publications with IFNAR2 and Necrosis
 Cardiovascular Diseases Antibodies  >6 publications with IFNAR2 and Cardiovascular Diseases
 Inflammation Antibodies  >6 publications with IFNAR2 and Inflammation
 Kidney Diseases Antibodies  >5 publications with IFNAR2 and Kidney Diseases

Organs/Tissues associated with IFNAR2 elisa kit

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >41 publications with IFNAR2 and Blood
 Liver Antibodies  >23 publications with IFNAR2 and Liver
 Lung Antibodies  >8 publications with IFNAR2 and Lung
 Bone Marrow Antibodies  >6 publications with IFNAR2 and Bone Marrow
 Kidney Antibodies  >6 publications with IFNAR2 and Kidney
 Uterus Antibodies  >5 publications with IFNAR2 and Uterus
 Brain Antibodies  >4 publications with IFNAR2 and Brain
 Spleen Antibodies  >3 publications with IFNAR2 and Spleen
 Skin Antibodies  >1 publications with IFNAR2 and Skin
 Lymph Node Antibodies  >1 publications with IFNAR2 and Lymph Node
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