CD36 Molecule (Thrombospondin Receptor) (CD36) ELISA Kit for Rat

CD36: Binds to collagen, thrombospondin, anionic phospholipids and oxidized low-density lipoprotein (oxLDL). May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport (By similarity). Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects (By similarity). As a coreceptor for TLR4-TLR6, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42 binding, rapidly induces the formation of a heterodimer of TLR4 and TLR6, which is internalized and triggers inflammatory signals, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion

Protein type: Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: Golgi apparatus; extracellular space; cell surface; protein complex; mitochondrion; intracellular membrane-bound organelle; endoplasmic reticulum; integral to membrane; caveola; lipid raft; membrane; apical part of cell; plasma membrane; intracellular; sarcolemma; external side of plasma membrane

Molecular Function: low-density lipoprotein receptor activity; protein binding; transforming growth factor beta binding; low-density lipoprotein binding; high-density lipoprotein binding; lipid binding

Biological Process: positive regulation of blood coagulation; cGMP-mediated signaling; positive regulation of interleukin-12 production; phagocytosis, recognition; negative regulation of transcription from RNA polymerase II promoter; pattern recognition receptor signaling pathway; signal transduction; fatty acid metabolic process; negative regulation of transcription factor import into nucleus; response to estradiol stimulus; low density lipoprotein mediated signaling; sequestering of lipid; cell surface receptor linked signal transduction; positive regulation of MAPKKK cascade; positive regulation of cell-matrix adhesion; cell adhesion; response to nutrient; long-chain fatty acid transport; response to drug; receptor-mediated endocytosis; cholesterol transport; positive regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of systemic arterial blood pressure; positive regulation of interleukin-6 production; long-chain fatty acid metabolic process; positive regulation of tumor necrosis factor production; positive regulation of peptidyl-tyrosine phosphorylation; defense response to Gram-positive bacterium; negative regulation of angiogenesis; triacylglycerol metabolic process; gut development; cellular response to insulin stimulus; response to mechanical stimulus; lipoprotein transport; fatty acid oxidation; response to activity; positive regulation of phagocytosis, engulfment; plasma membrane long-chain fatty acid transport; nitric oxide mediated signal transduction; fatty acid transport; apoptotic cell clearance; positive regulation of cytokine secretion