Wingless-Type MMTV Integration Site Family, Member 3 (WNT3) ELISA Kit for Mouse

WNT3: Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube. Defects in WNT3 are the cause of autosomal recessive tetra-amelia (ARTTRA). Tetra-amelia is a rare human genetic disorder characterized by complete absence of all four limbs and other anomalies such as craniofacial, nervous system, pulmonary, skeletal and urogenital defects. Belongs to the Wnt family.

Protein type: Secreted, signal peptide; Oncoprotein; Secreted

Cellular Component: proteinaceous extracellular matrix; extracellular space; cytoplasm; extracellular region

Molecular Function: protein domain specific binding; protein binding; frizzled binding; receptor binding

Biological Process: limb development; embryonic forelimb morphogenesis; axon guidance; Wnt receptor signaling pathway; multicellular organismal development; cell morphogenesis; dorsal/ventral axis specification; positive regulation of collateral sprouting in the absence of injury; Wnt receptor signaling pathway through beta-catenin; signal transduction; negative regulation of axon extension involved in axon guidance; embryonic hindlimb morphogenesis; Spemann organizer formation at the anterior end of the primitive streak; anterior/posterior pattern formation; limb bud formation; organ morphogenesis; mesoderm formation; cell-cell signaling; gamete generation; anatomical structure formation; anterior/posterior axis specification