Syntaxin 1a (Brain) (STX1A) ELISA Kit for Human

Name: Human STX1A ELISA Kit; Syntaxin 1a (Brain); MyBioSource
Brand: MyBioSource
SKU: MBS912583
Price: 295 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS912583

Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for STX1A has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any STX1A present is bound by the… More details

$295 / 24-Strip-Wells (LIMIT 1) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Request Current Manual

Product Overview

Online Datasheet in PDF

Product Name

syntaxin 1A (brain) (STX1A), ELISA Kit

Full Product Name

Human Syntaxin-1A, STX1A ELISA Kit

Product Gene Name

STX1A elisa kit

Product Synonym Names

Human Syntaxin-1A (STX1A) ELISA kit; HPC-1; STX1; p35-1; syntaxin 1A; syntaxin 1A (brain)

Species Reactivity

Human

Assay Type

Quantitative Sandwich

Samples

Serum, tissue homogenates

Detection Range

15.6 pg/ml-1000 pg/ml

Sensitivity

<3.9 pg/ml

Specificity

This assay has high sensitivity and excellent specificity for detection of human STX1A. No significant cross-reactivity or interference between human STX1A and analogues was observed.

Preparation and Storage

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

Inter-assay Precision

Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.

Intra-assay Precision

Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess.

Molecular Weight

33,023 Da

OMIM

186590

3D Structure

ModBase 3D Structure for Q16623

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of STX1A elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for STX1A purchase

MBS912583 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the syntaxin 1A (brain) (STX1A) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing STX1A. The ELISA analytical biochemical technique of the MBS912583 kit is based on STX1A antibody-STX1A antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect STX1A antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, STX1A. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for STX1A. It may not necessarily be applicable to this product.

NCBI GI #

259906442

NCBI GeneID

6804

NCBI Accession #

NP_001159375.1

UniProt Primary Accession #

Q16623

UniProt Secondary Accession #

O15447; O15448; Q12936; Q75MD9; Q7Z5K3; Q9BPZ6

UniProt Related Accession #

Q16623

GenBank Nucleotide #

NM_001165903.1

NCBI Official Full Name

syntaxin-1A isoform 2

NCBI Official Synonym Full Names

syntaxin 1A (brain)

NCBI Official Symbol

STX1A

NCBI Official Synonym Symbols

STX1; HPC-1; P35-1; SYN1A

UniProt Protein Name

Syntaxin-1A

UniProt Synonym Protein Names

Neuron-specific antigen HPC-1

Protein Family

Syntaxin

UniProt Gene Name

STX1A

UniProt Synonym Gene Names

STX1

UniProt Entry Name

STX1A_HUMAN

NCBI Protein Information

syntaxin-1A; neuron-specific antigen HPC-1

NCBI Summary for STX1A

This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

UniProt Comments for STX1A

STX1A: a type IV membrane protein involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A. Three splice variant isoforms have been described.

Protein type: Vesicle; Membrane protein, integral

Chromosomal Location of Human Ortholog: 7q11.23

Cellular Component: SNARE complex; synaptic vesicle; neuron projection; synaptic vesicle membrane; extracellular region; plasma membrane; integral to membrane; endomembrane system; actomyosin; cytosol; cell junction; secretory granule

Molecular Function: protein binding, bridging; protein domain specific binding; SNAP receptor activity; myosin binding; protein N-terminus binding; calcium-dependent protein binding; ATP-dependent protein binding; SNARE binding; protein binding; chloride channel inhibitor activity; protein heterodimerization activity; myosin head/neck binding; calcium channel inhibitor activity; glycoprotein binding; kinase binding

Biological Process: response to gravity; neurotransmitter secretion; pathogenesis; positive regulation of neurotransmitter secretion; calcium ion-dependent exocytosis; synaptic vesicle fusion to presynaptic membrane; synaptic transmission; intracellular protein transport; vesicle docking; cellular protein metabolic process; glutamate secretion; energy reserve metabolic process; regulation of insulin secretion; positive regulation of exocytosis; synaptic vesicle docking during exocytosis; secretion by cell

Research Articles on STX1A

1. The clinical relevance of STX1A variants in CF

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with STX1A elisa kit

Reference Product	PubMed Publications
SNAP25 elisa kit	>92 publications with STX1A and SNAP25
VAMP2 elisa kit	>30 publications with STX1A and VAMP2
NSF elisa kit	>24 publications with STX1A and NSF
STXBP1 elisa kit	>19 publications with STX1A and STXBP1
SNAP23 elisa kit	>16 publications with STX1A and SNAP23
SYT1 elisa kit	>13 publications with STX1A and SYT1
CFTR elisa kit	>13 publications with STX1A and CFTR
STXBP2 elisa kit	>7 publications with STX1A and STXBP2
SLC6A1 elisa kit	>7 publications with STX1A and SLC6A1
VAMP8 elisa kit	>6 publications with STX1A and VAMP8

Pathways associated with STX1A elisa kit

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Diabetes Pathways antibodies	Diabetes Pathways Diagram
Disease Pathway antibodies	Disease Pathway Diagram
Dopamine Neurotransmitter Release Cycle Pathway antibodies	Dopamine Neurotransmitter Release Cycle Pathway Diagram
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GABA Synthesis, Release, Reuptake And Degradation Pathway antibodies	GABA Synthesis, Release, Reuptake And Degradation Pathway Diagram
Glutamate Neurotransmitter Release Cycle Pathway antibodies	Glutamate Neurotransmitter Release Cycle Pathway Diagram

Diseases associated with STX1A elisa kit

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>27 publications with STX1A and Nervous System Diseases
Fibrosis Antibodies	>13 publications with STX1A and Fibrosis
Neurobehavioral Manifestations Antibodies	>13 publications with STX1A and Neurobehavioral Manifestations
Mental Disorders Antibodies	>12 publications with STX1A and Mental Disorders
Cardiovascular Diseases Antibodies	>11 publications with STX1A and Cardiovascular Diseases
Heart Diseases Antibodies	>10 publications with STX1A and Heart Diseases
Brain Diseases Antibodies	>9 publications with STX1A and Brain Diseases
Diabetes Mellitus Antibodies	>7 publications with STX1A and Diabetes Mellitus
Drug Toxicity Antibodies	>6 publications with STX1A and Drug Toxicity
Disease Models, Animal Antibodies	>5 publications with STX1A and Disease Models, Animal

Organs/Tissues associated with STX1A elisa kit

Organ/Tissue Name	Pubmed Publications
Nerve Antibodies	>286 publications with STX1A and Nerve
Brain Antibodies	>142 publications with STX1A and Brain
Pancreas Antibodies	>32 publications with STX1A and Pancreas
Embryonic Tissue Antibodies	>28 publications with STX1A and Embryonic Tissue
Kidney Antibodies	>21 publications with STX1A and Kidney
Muscle Antibodies	>17 publications with STX1A and Muscle
Eye Antibodies	>13 publications with STX1A and Eye
Lung Antibodies	>8 publications with STX1A and Lung
Ganglia Antibodies	>6 publications with STX1A and Ganglia
Mouth Antibodies	>6 publications with STX1A and Mouth