Wingless-Type MMTV Integration Site Family, Member 10b (WNT10B) ELISA Kit for Mouse

WNT10B: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Defects in WNT10B are the cause of split-hand/foot malformation type 6 (SHFM6). SHFM is a limb malformation involving the central rays of the autopod and presenting with syndactyly, median clefts of the hands and feet, and aplasia and/or hypoplasia of the phalanges, metacarpals, and metatarsals. SHFM6 is a autosomal recessive disorder. Belongs to the Wnt family.

Protein type: Secreted; Secreted, signal peptide

Cellular Component: extracellular space; proteinaceous extracellular matrix; extracellular region

Molecular Function: frizzled binding; receptor binding

Biological Process: regulation of fat cell differentiation; positive regulation of apoptosis; multicellular organismal development; regulation of protein metabolic process; skeletal muscle fiber development; Wnt receptor signaling pathway through beta-catenin; negative regulation of transcription from RNA polymerase II promoter; signal transduction; neuron differentiation; cell-cell signaling; positive regulation of cell proliferation; positive regulation of epithelial cell differentiation; G2/M transition of mitotic cell cycle; positive regulation of transcriptional preinitiation complex assembly; cell cycle arrest; negative regulation of epithelial cell proliferation; smoothened signaling pathway; Wnt receptor signaling pathway; cell fate commitment; sensory perception of taste; protein stabilization; regulation of proteasomal ubiquitin-dependent protein catabolic process; skeletal muscle regeneration; negative regulation of fat cell differentiation; positive regulation of bone mineralization; positive regulation of ossification; regulation of transcription from RNA polymerase II promoter; positive regulation of osteoblast differentiation; organ morphogenesis; regulation of skeletal muscle development; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; lipid metabolic process; positive regulation of anagen; myoblast cell differentiation involved in skeletal muscle regeneration