Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2b (GRIN2B) ELISA Kit for Mouse

NMDAR2B: an NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. Mediates neuronal functions in glutamate neurotransmission. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death.

Protein type: Channel, calcium; Membrane protein, integral; Channel, ligand-gated; Membrane protein, multi-pass

Cellular Component: neuron projection; cell surface; postsynaptic density; dendritic spine; integral to membrane; terminal button; Z disc; N-methyl-D-aspartate selective glutamate receptor complex; presynaptic membrane; postsynaptic membrane; synaptic vesicle; membrane; plasma membrane; synapse; cell junction

Molecular Function: neurotransmitter binding; interleukin-1 receptor binding; zinc ion binding; calcium channel activity; metal ion binding; ion channel activity; beta-catenin binding; drug binding; receptor activity; ionotropic glutamate receptor binding; protein binding; extracellular-glutamate-gated ion channel activity; protein heterodimerization activity; ionotropic glutamate receptor activity; glycine binding; N-methyl-D-aspartate selective glutamate receptor activity; cell adhesion molecule binding; cation channel activity; receptor binding; D2 dopamine receptor binding

Biological Process: regulation of long-term neuronal synaptic plasticity; fear response; behavioral fear response; startle response; rhythmic process; positive regulation of glutamate secretion; regulation of synaptic plasticity; receptor clustering; positive regulation of synaptic transmission; synaptic transmission; behavioral response to pain; learning and/or memory; transport; calcium ion transport; associative learning; cation transport; regulation of action potential; synaptic transmission, glutamatergic; in utero embryonic development; learning; memory; detection of mechanical stimulus involved in sensory perception of pain; embryonic development; regulation of postsynaptic membrane potential; response to ethanol; sensory organ development; suckling behavior; ionotropic glutamate receptor signaling pathway; regulation of MAPKKK cascade; ion transport; regulation of excitatory postsynaptic membrane potential; regulation of neuronal synaptic plasticity