Growth Regulated Oncogene Beta (GROB) ELISA Kit for Fish

Name: Fish GROB ELISA Kit; Growth Regulated Oncogene Beta; MyBioSource
Brand: MyBioSource
SKU: MBS009231
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS009231

MBS009231 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Growth Regulated Oncogene Beta (GROB) ELISA Kit target analytes in biological samples. The concentration gradients of… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

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Product Overview

Online Datasheet in PDF

Product Name

Growth Regulated Oncogene Beta (GROB), ELISA Kit

Full Product Name

Fish Growth Regulated Oncogene Beta ELISA Kit

Product Gene Name

GROB elisa kit

Species Reactivity

Fish

Assay Type

Sandwich

Preparation and Storage

Store all reagents at 2-8 degree C

Molecular Weight

17,818 Da

OMIM

604948

3D Structure

ModBase 3D Structure for O75293

Other Notes

Small volumes of GROB elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GROB. It may not necessarily be applicable to this product.

NCBI GI #

86991436

NCBI GeneID

4616

NCBI Accession #

NP_056490.2

UniProt Primary Accession #

O75293

UniProt Secondary Accession #

O75960; Q17R46; A8KAM2

UniProt Related Accession #

O75293

GenBank Nucleotide #

NM_015675.3

NCBI Official Full Name

growth arrest and DNA damage-inducible protein GADD45 beta

NCBI Official Synonym Full Names

growth arrest and DNA-damage-inducible, beta

NCBI Official Symbol

GADD45B

NCBI Official Synonym Symbols

MYD118; GADD45BETA

UniProt Protein Name

Growth arrest and DNA damage-inducible protein GADD45 beta

UniProt Synonym Protein Names

Myeloid differentiation primary response protein MyD118; Negative growth regulatory protein MyD118

UniProt Gene Name

GADD45B

UniProt Synonym Gene Names

MYD118

UniProt Entry Name

GA45B_HUMAN

NCBI Protein Information

growth arrest and DNA damage-inducible protein GADD45 beta; negative growth regulatory protein MyD118; myeloid differentiation primary response protein MyD118

NCBI Summary for GROB

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. [provided by RefSeq, Jul 2008]

UniProt Comments for GROB

GADD45B: Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK. Belongs to the GADD45 family.

Protein type: Cell development/differentiation; Apoptosis

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding

Biological Process: activation of MAPKK activity; apoptosis; positive regulation of apoptosis; regulation of cell cycle; multicellular organismal development; activation of MAPKKK activity; positive regulation of JNK cascade; negative regulation of protein kinase activity; response to stress; cell differentiation

Research Articles on GROB

1. Gadd45B protects the liver through two entirely different processes: binding MKK7 to block damaging signal transduction or binding CAR to coactivate anabolic transcription. (Review)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GROB elisa kit

Reference Product	PubMed Publications
GADD45A elisa kit	>51 publications with GROB and GADD45A
GADD45G elisa kit	>34 publications with GROB and GADD45G
PCNA elisa kit	>13 publications with GROB and PCNA
MAP2K3 elisa kit	>3 publications with GROB and MAP2K3
IL18 elisa kit	>2 publications with GROB and IL18
CCNB1 elisa kit	>2 publications with GROB and CCNB1
MAP3K4 elisa kit	>2 publications with GROB and MAP3K4
JAK2 elisa kit	>1 publications with GROB and JAK2
MAP2K6 elisa kit	>1 publications with GROB and MAP2K6

Pathways associated with GROB elisa kit

Products by Pathway	Pathway Diagram
Adipogenesis Pathway antibodies	Adipogenesis Pathway Diagram
Cell Cycle Pathway antibodies	Cell Cycle Pathway Diagram
Cell Cycle Pathway antibodies	Cell Cycle Pathway Diagram
DNA Damage Response Pathway antibodies	DNA Damage Response Pathway Diagram
FoxO Signaling Pathway antibodies	FoxO Signaling Pathway Diagram
IL12-mediated Signaling Events Pathway antibodies	IL12-mediated Signaling Events Pathway Diagram
MAPK Signaling Pathway antibodies	MAPK Signaling Pathway Diagram
MAPK Signaling Pathway antibodies	MAPK Signaling Pathway Diagram
NF-kappa B Signaling Pathway antibodies	NF-kappa B Signaling Pathway Diagram
P38 MAPK Signaling Pathway antibodies	P38 MAPK Signaling Pathway Diagram

Diseases associated with GROB elisa kit

Disease Name	Pubmed Publications
Neoplasms Antibodies	>75 publications with GROB and Neoplasms
Necrosis Antibodies	>25 publications with GROB and Necrosis
Inflammation Antibodies	>22 publications with GROB and Inflammation
Disease Models, Animal Antibodies	>19 publications with GROB and Disease Models, Animal
Liver Diseases Antibodies	>18 publications with GROB and Liver Diseases
Liver Neoplasms Antibodies	>16 publications with GROB and Liver Neoplasms
Nervous System Diseases Antibodies	>14 publications with GROB and Nervous System Diseases
Carcinoma, Hepatocellular Antibodies	>13 publications with GROB and Carcinoma, Hepatocellular
Neoplasms, Experimental Antibodies	>13 publications with GROB and Neoplasms, Experimental
Lung Neoplasms Antibodies	>10 publications with GROB and Lung Neoplasms

Organs/Tissues associated with GROB elisa kit

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>44 publications with GROB and Blood
Liver Antibodies	>36 publications with GROB and Liver
Brain Antibodies	>25 publications with GROB and Brain
Lung Antibodies	>21 publications with GROB and Lung
Bone Antibodies	>16 publications with GROB and Bone
Bone Marrow Antibodies	>10 publications with GROB and Bone Marrow
Heart Antibodies	>10 publications with GROB and Heart
Muscle Antibodies	>9 publications with GROB and Muscle
Prostate Antibodies	>8 publications with GROB and Prostate
Ovary Antibodies	>6 publications with GROB and Ovary