Cytotoxic and Regulatory T Cell Molecule (CRTAM) ELISA Kit for Human

Name: Human CRTAM ELISA Kit; Cytotoxic and Regulatory T Cell Molecule; MyBioSource
Brand: MyBioSource
SKU: MBS925630
Price: 295 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS925630

MBS925630 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the cytotoxic and regulatory T cell molecule (CRTAM) ELISA Kit target analytes in biological samples. The concentration gradients of… More details

$295 / 24-Strip-Wells (LIMIT 1) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Request Current Manual

Product Overview

Online Datasheet in PDF

Product Name

cytotoxic and regulatory T cell molecule (CRTAM), ELISA Kit

Full Product Name

Human Cytotoxic and regulatory T-cell molecule, CRTAM ELISA Kit

Product Gene Name

CRTAM elisa kit

Product Synonym Names

Human Cytotoxic and regulatory T-cell molecule (CRTAM) ELISA kit; class I MHC restricted T cell associated molecule; class-I MHC-restricted T cell associated molecule; cytotoxic and regulatory T cell molecule

Species Reactivity

Human

Specificity

This assay has high sensitivity and excellent specificity for detection of Human CRTAM. No significant cross-reactivity or interference between Human CRTAM and analogues was observed.

Preparation and Storage

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

Intra-assay Precision

Intra-assay Precision (Precision within an assay): CV% is less than 8%
Three samples of known concentration were tested twenty times on one plate to assess.
Inter-assay Precision (Precision between assays): CV% is less than 10%
Three samples of known concentration were tested in twenty assays to assess.

Molecular Weight

44,641 Da

OMIM

612597

3D Structure

ModBase 3D Structure for O95727

Detection Wavelength

450 nm

Sample Volume

50-100ul

Protein Biological Process 1

Immunity

Protein Biological Process 3

Adaptive immunity

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of CRTAM elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CRTAM. It may not necessarily be applicable to this product.

NCBI GI #

51593098

NCBI GeneID

56253

NCBI Accession #

NP_062550.2

UniProt Primary Accession #

O95727

UniProt Secondary Accession #

Q59EI1; Q6IRX2

UniProt Related Accession #

O95727

GenBank Nucleotide #

NM_019604.2

NCBI Official Full Name

cytotoxic and regulatory T-cell molecule

NCBI Official Synonym Full Names

cytotoxic and regulatory T cell molecule

NCBI Official Symbol

CRTAM

NCBI Official Synonym Symbols

CD355

UniProt Protein Name

Cytotoxic and regulatory T-cell molecule

UniProt Synonym Protein Names

Class-I MHC-restricted T-cell-associated molecule; CD_antigen: CD355

Protein Family

Cytotoxic and regulatory T-cell molecule

UniProt Gene Name

CRTAM

UniProt Entry Name

CRTAM_HUMAN

NCBI Protein Information

cytotoxic and regulatory T-cell molecule; class I MHC restricted T cell associated molecule; class-I MHC-restricted T cell associated molecule; class-I MHC-restricted T-cell-associated molecule

NCBI Summary for CRTAM

The CRTAM gene is upregulated in CD4 (see MIM 186940)-positive and CD8 (see CD8A; MIM 186910)-positive T cells and encodes a type I transmembrane protein with V and C1-like Ig domains (Yeh et al., 2008 [PubMed 18329370]).[supplied by OMIM, Feb 2009]

UniProt Comments for CRTAM

CRTAM: Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. Belongs to the nectin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q24.1

Cellular Component: plasma membrane; integral to membrane

Molecular Function: receptor binding

Biological Process: regulation of immune response; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; detection of tumor cell; activated T cell proliferation; detection of stimulus; cell recognition; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of cytokine secretion; T cell mediated cytotoxicity

Research Articles on CRTAM

1. Case-control studies reveal malignant mesothelioma risk associated with variants in the SDK1, CRTAM and RASGRF2 genes.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with CRTAM elisa kit

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies	Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram

Diseases associated with CRTAM elisa kit

Disease Name	Pubmed Publications
Neoplasms Antibodies	>4 publications with CRTAM and Neoplasms
Lung Neoplasms Antibodies	>1 publications with CRTAM and Lung Neoplasms
Neoplasms, Experimental Antibodies	>1 publications with CRTAM and Neoplasms, Experimental
Asthma Antibodies	>1 publications with CRTAM and Asthma
Diabetes Mellitus Antibodies	>1 publications with CRTAM and Diabetes Mellitus

Organs/Tissues associated with CRTAM elisa kit

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>20 publications with CRTAM and Blood
Thymus Antibodies	>3 publications with CRTAM and Thymus
Spleen Antibodies	>2 publications with CRTAM and Spleen
Lung Antibodies	>2 publications with CRTAM and Lung
Brain Antibodies	>2 publications with CRTAM and Brain