Lysyl Oxidase-Like 1 (LOXL1) ELISA Kit for Human

Name: Human LOXL1 ELISA Kit; Lysyl Oxidase-Like 1; MyBioSource
Brand: MyBioSource
SKU: MBS931742
Price: 295 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS931742

Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for LOXL1 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any LOXL1 present is bound by the… More details

$295 / 24-Strip-Wells (LIMIT 1) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Request Current Manual

Product Overview

Online Datasheet in PDF

Product Name

lysyl oxidase-like 1 (LOXL1), ELISA Kit

Full Product Name

Human Lysyl oxidase homolog 1, LOXL1 ELISA Kit

Product Gene Name

LOXL1 elisa kit

Product Synonym Names

Human Lysyl oxidase homolog 1 (LOXL1) ELISA kit; LOL; LOXL; lysyl oxidase homolog 1; lysyl oxidase-like 1

Species Reactivity

Human

Assay Type

Quantitative Sandwich

Samples

Serum, plasma, cell culture supernates

Detection Range

0.156 ng/ml-10 ng/ml

Sensitivity

< 0.039 ng/ml

Specificity

This assay has high sensitivity and excellent specificity for detection of human LOXL1. No significant cross-reactivity or interference between human LOXL1 and analogues was observed.

Preparation and Storage

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

Inter-assay Precision

Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.

Intra-assay Precision

Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess.

Molecular Weight

63,110 Da

OMIM

gene 177650

3D Structure

ModBase 3D Structure for Q08397

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of LOXL1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LOXL1 purchase

MBS931742 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the lysyl oxidase-like 1 (LOXL1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing LOXL1. The ELISA analytical biochemical technique of the MBS931742 kit is based on LOXL1 antibody-LOXL1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect LOXL1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, LOXL1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for LOXL1. It may not necessarily be applicable to this product.

NCBI GI #

67782346

NCBI GeneID

4016

NCBI Accession #

NP_005567.2

UniProt Primary Accession #

Q08397

UniProt Secondary Accession #

Q6NUL3; Q96BW7

UniProt Related Accession #

Q08397

GenBank Nucleotide #

NM_005576.2

NCBI Official Full Name

lysyl oxidase homolog 1 preproprotein

NCBI Official Synonym Full Names

lysyl oxidase-like 1

NCBI Official Symbol

LOXL1

NCBI Official Synonym Symbols

LOL; LOXL

UniProt Protein Name

Lysyl oxidase homolog 1

UniProt Synonym Protein Names

Lysyl oxidase-like protein 1; LOL

Protein Family

Lysyl oxidase

UniProt Gene Name

LOXL1

UniProt Synonym Gene Names

LOXL; LOL

UniProt Entry Name

LOXL1_HUMAN

NCBI Protein Information

lysyl oxidase homolog 1; lysyl oxidase-like protein 1

NCBI Summary for LOXL1

This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008]

UniProt Comments for LOXL1

LOXL1: Active on elastin and collagen substrates. Genetic variations in LOXL1 are a cause of susceptibility to exfoliation syndrome (XFS); also called exfoliation glaucoma (XFG). XFS is a disorder characterized by accumulation of abnormal fibrillar deposits in the anterior segment of the eye. In addition to being a cause of glaucoma and glaucomatous optic neuropathy, exfoliation syndrome has also been associated with lens zonule weakness, cataract formation, and systemic vascular complications due to deposition of exfoliation material in extraocular tissues. Susceptibility to exfoliation syndrome is conferred by a risk haplotype that includes two LOXL1 coding non-synonymous SNPs (Arg141Leu and Gly153Asp) and one intronic SNP. Arg141Leu and Gly153Asp are sufficient to confer disease susceptibility in some populations. Belongs to the lysyl oxidase family.

Protein type: EC 1.4.3.-; Secreted, signal peptide; Oxidoreductase; Extracellular matrix; Secreted

Chromosomal Location of Human Ortholog: 15q22

Cellular Component: extracellular matrix; extracellular space; acrosome; extracellular region; basement membrane

Molecular Function: copper ion binding; oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

Biological Process: extracellular matrix organization and biogenesis; response to lipopolysaccharide; protein amino acid deamination

Disease: Exfoliation Syndrome

Research Articles on LOXL1

1. allele T of LOXL1 rs41435250 is a novel risk genetic factor for pseudoexfoliation syndrome/pseudoexfoliation glaucoma development.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with LOXL1 elisa kit

Reference Product	PubMed Publications
FBLN5 elisa kit	>10 publications with LOXL1 and FBLN5
FBN1 elisa kit	>3 publications with LOXL1 and FBN1
ELN elisa kit	>3 publications with LOXL1 and ELN
COL5A1 elisa kit	>1 publications with LOXL1 and COL5A1

Pathways associated with LOXL1 elisa kit

Products by Pathway	Pathway Diagram
Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies	Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram
Collagen Formation Pathway antibodies	Collagen Formation Pathway Diagram
Crosslinking Of Collagen Fibrils Pathway antibodies	Crosslinking Of Collagen Fibrils Pathway Diagram
Elastic Fibre Formation Pathway antibodies	Elastic Fibre Formation Pathway Diagram
Extracellular Matrix Organization Pathway antibodies	Extracellular Matrix Organization Pathway Diagram

Diseases associated with LOXL1 elisa kit

Disease Name	Pubmed Publications
Exfoliation Syndrome Antibodies	>85 publications with LOXL1 and Exfoliation Syndrome
Cardiovascular Diseases Antibodies	>16 publications with LOXL1 and Cardiovascular Diseases
Disease Models, Animal Antibodies	>11 publications with LOXL1 and Disease Models, Animal
Hypertension Antibodies	>7 publications with LOXL1 and Hypertension
Fibrosis Antibodies	>6 publications with LOXL1 and Fibrosis
Nervous System Diseases Antibodies	>5 publications with LOXL1 and Nervous System Diseases
Inflammation Antibodies	>4 publications with LOXL1 and Inflammation
Hypertrophy Antibodies	>4 publications with LOXL1 and Hypertrophy
Heart Diseases Antibodies	>4 publications with LOXL1 and Heart Diseases
Urinary Bladder Neoplasms Antibodies	>3 publications with LOXL1 and Urinary Bladder Neoplasms

Organs/Tissues associated with LOXL1 elisa kit

Organ/Tissue Name	Pubmed Publications
Eye Antibodies	>42 publications with LOXL1 and Eye
Connective Tissue Antibodies	>17 publications with LOXL1 and Connective Tissue
Vascular Antibodies	>15 publications with LOXL1 and Vascular
Muscle Antibodies	>11 publications with LOXL1 and Muscle
Skin Antibodies	>10 publications with LOXL1 and Skin
Bone Antibodies	>7 publications with LOXL1 and Bone
Nerve Antibodies	>6 publications with LOXL1 and Nerve
Bladder Antibodies	>6 publications with LOXL1 and Bladder
Lung Antibodies	>4 publications with LOXL1 and Lung
Kidney Antibodies	>4 publications with LOXL1 and Kidney