Latent Transforming Growth Factor Beta Binding Protein 1 (LTBP1) ELISA Kit for Human

Name: Human LTBP1 ELISA Kit; MyBioSource
Brand: MyBioSource
SKU: MBS933281
Price: 295 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS933281

Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for LTBP1 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any LTBP1 present is bound by the… More details

$295 / 24-Strip-Wells (LIMIT 1) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

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Product Overview

Online Datasheet in PDF

Product Name

latent transforming growth factor beta binding protein 1 (LTBP1), ELISA Kit

Full Product Name

Human Latent-transforming growth factor beta-binding protein 1, LTBP1 ELISA Kit

Product Gene Name

LTBP1 elisa kit

Product Synonym Names

Human Latent-transforming growth factor beta-binding protein 1 (LTBP1) ELISA kit; MGC163161; TGF-beta1-BP-1; latent-transforming growth factor beta-binding protein 1; transforming growth factor beta-1-binding protein 1; latent transforming growth factor beta binding protein 1

Species Reactivity

Human

Samples

Serum, plasma, tissue homogenates

Detection Range

0.156 ng/ml -10 ng/mL

Sensitivity

<0.039 ng/mL

Specificity

This assay has high sensitivity and excellent specificity for detection of human LTBP1. No significant cross-reactivity or interference between human LTBP1 and analogues was observed.

Preparation and Storage

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

Inter-assay Precision

Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.

Intra-assay Precision

Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess.

Molecular Weight

186,796 Da

OMIM

150390

3D Structure

ModBase 3D Structure for Q14766

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of LTBP1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LTBP1 purchase

MBS933281 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the latent transforming growth factor beta binding protein 1 (LTBP1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing LTBP1. The ELISA analytical biochemical technique of the MBS933281 kit is based on LTBP1 antibody-LTBP1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect LTBP1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, LTBP1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for LTBP1. It may not necessarily be applicable to this product.

NCBI GI #

261337167

NCBI GeneID

4052

NCBI Accession #

NP_000618.3

UniProt Primary Accession #

Q14766

UniProt Secondary Accession #

P22064; Q53SD8; Q53SF3; Q53SG1; Q59HF7; Q8TD95; A1L3V1

UniProt Related Accession #

Q14766

GenBank Nucleotide #

NM_000627.3

NCBI Official Full Name

latent-transforming growth factor beta-binding protein 1 isoform LTBP-1S

NCBI Official Synonym Full Names

latent transforming growth factor beta binding protein 1

NCBI Official Symbol

LTBP1

UniProt Protein Name

Latent-transforming growth factor beta-binding protein 1

UniProt Synonym Protein Names

Transforming growth factor beta-1-binding protein 1; TGF-beta1-BP-1

Protein Family

Latent-transforming growth factor beta-binding protein

UniProt Gene Name

LTBP1

UniProt Synonym Gene Names

LTBP-1; TGF-beta1-BP-1

UniProt Entry Name

LTBP1_HUMAN

NCBI Protein Information

latent-transforming growth factor beta-binding protein 1; LTBP-1; TGF-beta1-BP-1; transforming growth factor beta-1-binding protein 1

NCBI Summary for LTBP1

The protein encoded by this gene belongs to the family of latent TGF-beta binding proteins (LTBPs). The secretion and activation of TGF-betas is regulated by their association with latency-associated proteins and with latent TGF-beta binding proteins. The product of this gene targets latent complexes of transforming growth factor beta to the extracellular matrix, where the latent cytokine is subsequently activated by several different mechanisms. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

UniProt Comments for LTBP1

LTBP1: May be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGFB1. May have a structural role in the extra cellular matrix (ECM). Belongs to the LTBP family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Chaperone; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2p22-p21

Cellular Component: extracellular matrix; proteinaceous extracellular matrix; protein complex; microfibril; extracellular region

Molecular Function: transforming growth factor beta receptor activity; protein binding; transforming growth factor beta binding; microfibril binding; calcium ion binding

Biological Process: extracellular matrix organization and biogenesis; transmembrane receptor protein serine/threonine kinase signaling pathway

Research Articles on LTBP1

1. these results suggested that the C allele could increase TGF-beta secretion which suppresses antitumour immune responses and may affect the Oral squamous cell carcinoma risk.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with LTBP1 elisa kit

Reference Product	PubMed Publications
TGFB1 elisa kit	>46 publications with LTBP1 and TGFB1
TGFB2 elisa kit	>12 publications with LTBP1 and TGFB2
TGFB3 elisa kit	>6 publications with LTBP1 and TGFB3
AHR elisa kit	>5 publications with LTBP1 and AHR
THBS1 elisa kit	>3 publications with LTBP1 and THBS1

Pathways associated with LTBP1 elisa kit

Products by Pathway	Pathway Diagram
Elastic Fibre Formation Pathway antibodies	Elastic Fibre Formation Pathway Diagram
Extracellular Matrix Organization Pathway antibodies	Extracellular Matrix Organization Pathway Diagram
Integrated Pancreatic Cancer Pathway antibodies	Integrated Pancreatic Cancer Pathway Diagram
Molecules Associated With Elastic Fibres Pathway antibodies	Molecules Associated With Elastic Fibres Pathway Diagram
TGF Beta Signaling Pathway antibodies	TGF Beta Signaling Pathway Diagram
TGF-beta Signaling Pathway antibodies	TGF-beta Signaling Pathway Diagram
TGF-beta Signaling Pathway antibodies	TGF-beta Signaling Pathway Diagram

Diseases associated with LTBP1 elisa kit

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>17 publications with LTBP1 and Cardiovascular Diseases
Heart Diseases Antibodies	>10 publications with LTBP1 and Heart Diseases
Congenital Abnormalities Antibodies	>9 publications with LTBP1 and Congenital Abnormalities
Heart Defects, Congenital Antibodies	>5 publications with LTBP1 and Heart Defects, Congenital
Disease Models, Animal Antibodies	>5 publications with LTBP1 and Disease Models, Animal
Liver Diseases Antibodies	>5 publications with LTBP1 and Liver Diseases
Breast Neoplasms Antibodies	>4 publications with LTBP1 and Breast Neoplasms
Adenocarcinoma Antibodies	>4 publications with LTBP1 and Adenocarcinoma
Kidney Diseases Antibodies	>4 publications with LTBP1 and Kidney Diseases
Ovarian Neoplasms Antibodies	>3 publications with LTBP1 and Ovarian Neoplasms

Organs/Tissues associated with LTBP1 elisa kit

Organ/Tissue Name	Pubmed Publications
Bone Antibodies	>19 publications with LTBP1 and Bone
Vascular Antibodies	>18 publications with LTBP1 and Vascular
Connective Tissue Antibodies	>15 publications with LTBP1 and Connective Tissue
Lung Antibodies	>14 publications with LTBP1 and Lung
Muscle Antibodies	>12 publications with LTBP1 and Muscle
Heart Antibodies	>11 publications with LTBP1 and Heart
Skin Antibodies	>10 publications with LTBP1 and Skin
Kidney Antibodies	>10 publications with LTBP1 and Kidney
Embryonic Tissue Antibodies	>10 publications with LTBP1 and Embryonic Tissue
Liver Antibodies	>7 publications with LTBP1 and Liver