Superoxide Dismutase 2, Mitochondrial (SOD2) ELISA Kit for Mouse

SOD2: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Genetic variation in SOD2 is associated with susceptibility to microvascular complications of diabetes type 6 (MVCD6). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new- onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Belongs to the iron/manganese superoxide dismutase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.15.1.1; Oxidoreductase; Mitochondrial

Cellular Component: mitochondrion; cytoplasm; mitochondrial inner membrane; intracellular; myelin sheath

Molecular Function: identical protein binding; protein binding; DNA binding; manganese ion binding; metal ion binding; superoxide dismutase activity; oxidoreductase activity; oxygen binding

Biological Process: oxygen homeostasis; positive regulation of nitric oxide biosynthetic process; removal of superoxide radicals; heart development; locomotory behavior; vasodilation; post-embryonic development; age-dependent response to oxidative stress; protein homotetramerization; negative regulation of cell proliferation; apoptotic mitochondrial changes; glutathione metabolic process; sensory perception of sound; regulation of mitochondrial membrane potential; acetylcholine vasodilation involved in regulation of systemic arterial blood pressure; regulation of catalytic activity; regulation of blood pressure; response to gamma radiation; hemopoiesis; response to axon injury; negative regulation of neuron apoptosis; protein homooligomerization; response to drug; response to nutrient levels; erythrophore differentiation; mitochondrion organization and biogenesis; release of cytochrome c from mitochondria; response to superoxide; superoxide metabolic process; liver development; negative regulation of fat cell differentiation; regulation of transcription from RNA polymerase II promoter; iron ion homeostasis; response to reactive oxygen species; response to hyperoxia; DNA damage response, signal transduction resulting in induction of apoptosis; response to hydrogen peroxide; age-dependent response to reactive oxygen species; negative regulation of fibroblast proliferation; detection of oxygen; hydrogen peroxide metabolic process; neuron development; response to oxidative stress; response to activity; induction of apoptosis by oxidative stress; superoxide release; hydrogen peroxide biosynthetic process; negative regulation of apoptosis