Follistatin-Like 3 (Secreted Glycoprotein) (FSTL3) ELISA Kit for Human

FSTL3: Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10. A chromosomal aberration involving FSTL3 is found in a case of B-cell chronic lymphocytic leukemia. Translocation t(11;19)(q13;p13) with CCDN1. 2 isoforms of the human protein are produced by alternative initiation.

Protein type: Oncoprotein; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 19p13

Cellular Component: nucleoplasm; Golgi apparatus; extracellular space; extracellular region; nucleus; secretory granule

Molecular Function: protein binding; fibronectin binding; activin binding

Biological Process: negative regulation of osteoclast differentiation; ossification; transcription, DNA-dependent; adrenal gland development; male gonad development; negative regulation of BMP signaling pathway; regulation of transcription from RNA polymerase II promoter; negative regulation of activin receptor signaling pathway; positive regulation of cell-cell adhesion; hemopoietic progenitor cell differentiation; positive regulation of transcription from RNA polymerase II promoter; spermatogenesis; kidney development; lung development