Reelin (RELN) ELISA Kit for Mouse

reelin: Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation. Defects in RELN are the cause of lissencephaly type 2 (LIS2); also known as lissencephaly with cerebellar hypoplasia or Norman-Roberts syndrome. LIS2 is a classic type lissencephaly associated with abnormalities of the cerebellum, hippocampus and brainstem. Individuals with LIS2 are severely ataxic, mentally retarded and suffer from epilepsy. Belongs to the reelin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide; EC 3.4.21.-; Motility/polarity/chemotaxis; Protease; Cell development/differentiation; Cell adhesion

Cellular Component: proteinaceous extracellular matrix; extracellular space; neuron projection; cell soma; axon; cytoplasm; dendrite; extracellular region; perikaryon

Molecular Function: peptidase activity; protein binding; hydrolase activity; serine-type peptidase activity; metal ion binding

Biological Process: axon guidance; cellular morphogenesis during differentiation; peptidyl-tyrosine phosphorylation; central nervous system development; spinal cord patterning; multicellular organismal development; neuron migration; locomotory behavior; response to pain; proteolysis; positive regulation of synaptic transmission, glutamatergic; glial cell differentiation; forebrain development; dendrite development; cell adhesion; positive regulation of TOR signaling pathway; thyroid hormone metabolic process; associative learning; layer formation in the cerebral cortex; regulation of behavior; regulation of synaptic transmission; cell migration; dentate gyrus development; cerebral cortex tangential migration; hippocampus development; activation of CREB transcription factor; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of small GTPase mediated signal transduction; positive regulation of peptidyl-tyrosine phosphorylation; long-term memory; regulation of gene expression; positive regulation of protein kinase activity; brain development; cerebral cortex development