Delta-Like 4 (Drosophila) (DLL4) ELISA Kit for Human

Name: Human DLL4 ELISA Kit; Delta-Like 4 (Drosophila); MyBioSource
Brand: MyBioSource
SKU: MBS942396
Price: 295 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS942396

MBS942396 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the delta-like 4 (Drosophila) (DLL4) ELISA Kit target analytes in biological samples. The concentration gradients of the kit… More details

$295 / 24-Strip-Wells (LIMIT 1) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Request Current Manual

Product Overview

Online Datasheet in PDF

Product Name

delta-like 4 (Drosophila) (DLL4), ELISA Kit

Full Product Name

Human Delta-like protein 4, DLL4 ELISA Kit

Product Gene Name

DLL4 elisa kit

Product Synonym Names

Human Delta-like protein 4 (DLL4) ELISA kit; MGC126344; hdelta2; delta 4; delta ligand 4; delta-like 4 homolog; delta-like 4 protein; notch ligand DLL4; notch ligand delta-2; delta-like 4 (Drosophila)

Species Reactivity

Human

Samples

Serum, plasma, tissue homogenates

Detection Range

23.5 pg/ml-1500 pg/ml

Sensitivity

5.8 pg/ml

Specificity

This assay has high sensitivity and excellent specificity for detection of Human DLL4. No significant cross-reactivity or interference between Human DLL4 and analogues was observed.

Preparation and Storage

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

Intra-assay Precision

Intra-assay Precision (Precision within an assay): CV% is less than 8%
Three samples of known concentration were tested twenty times on one plate to assess.
Inter-assay Precision (Precision between assays): CV% is less than 10%
Three samples of known concentration were tested in twenty assays to assess.

Molecular Weight

74,605 Da

OMIM

605185

3D Structure

ModBase 3D Structure for Q9NR61

Detection Wavelength

450 nm

Sample Volume

50-100ul

Protein Biological Process 1

Developmental Protein

Protein Biological Process 3

Differentiation

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of DLL4 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for DLL4. It may not necessarily be applicable to this product.

NCBI GI #

9506545

NCBI GeneID

54567

NCBI Accession #

NP_061947.1

UniProt Primary Accession #

Q9NR61

UniProt Secondary Accession #

Q3KP23; Q9NQT9

UniProt Related Accession #

Q9NR61

GenBank Nucleotide #

NM_019074.3

NCBI Official Full Name

delta-like protein 4

NCBI Official Synonym Full Names

delta-like 4 (Drosophila)

NCBI Official Symbol

DLL4

NCBI Official Synonym Symbols

hdelta2

UniProt Protein Name

Delta-like protein 4

UniProt Synonym Protein Names

Drosophila Delta homolog 4; Delta4

Protein Family

Delta-like protein

UniProt Gene Name

DLL4

UniProt Synonym Gene Names

UNQ1895/PRO4341; Delta4

UniProt Entry Name

DLL4_HUMAN

NCBI Protein Information

delta-like protein 4; delta4; delta 4; delta ligand 4; notch ligand DLL4; delta-like 4 homolog; delta-like 4 protein; notch ligand delta-2; drosophila Delta homolog 4

NCBI Summary for DLL4

This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. [provided by RefSeq, Jul 2008]

UniProt Comments for DLL4

DLL4: Plays a role in the Notch signaling pathway. Activates Notch-1 and Notch-4. Binds to Notch-1 and Notch-4. Expressed in vascular endothelium.

Protein type: Cell development/differentiation; Membrane protein, integral

Chromosomal Location of Human Ortholog: 15q14

Cellular Component: integral to membrane; plasma membrane

Molecular Function: calcium ion binding; Notch binding

Biological Process: patterning of blood vessels; negative regulation of cell proliferation; Notch signaling pathway; regulation of neurogenesis; visual perception; blood circulation; Notch receptor processing; blood vessel remodeling; angiogenesis; negative regulation of transcription from RNA polymerase II promoter; signal transduction

Research Articles on DLL4

1. Demonstrate that the action of IFNgamma on endothelial cellss, but not other cells, is highly effective for tumour angiostasis, which involves down-regulating Dll4.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with DLL4 elisa kit

Reference Product	PubMed Publications
NOTCH1 elisa kit	>82 publications with DLL4 and NOTCH1
NOTCH4 elisa kit	>31 publications with DLL4 and NOTCH4

Pathways associated with DLL4 elisa kit

Products by Pathway	Pathway Diagram
Activated NOTCH1 Transmits Signal To The Nucleus Pathway antibodies	Activated NOTCH1 Transmits Signal To The Nucleus Pathway Diagram
Delta-Notch Signaling Pathway antibodies	Delta-Notch Signaling Pathway Diagram
Notch Signaling Pathway antibodies	Notch Signaling Pathway Diagram
Notch Signaling Pathway antibodies	Notch Signaling Pathway Diagram
Notch Signaling Pathway antibodies	Notch Signaling Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram
Signaling By NOTCH Pathway antibodies	Signaling By NOTCH Pathway Diagram
Signaling By NOTCH1 Pathway antibodies	Signaling By NOTCH1 Pathway Diagram
Signaling By NOTCH2 Pathway antibodies	Signaling By NOTCH2 Pathway Diagram
Signaling By NOTCH3 Pathway antibodies	Signaling By NOTCH3 Pathway Diagram

Diseases associated with DLL4 elisa kit

Disease Name	Pubmed Publications
Neovascularization, Pathologic Antibodies	>54 publications with DLL4 and Neovascularization, Pathologic
Carcinoma Antibodies	>22 publications with DLL4 and Carcinoma
Disease Models, Animal Antibodies	>19 publications with DLL4 and Disease Models, Animal
Vascular Diseases Antibodies	>16 publications with DLL4 and Vascular Diseases
Adenocarcinoma Antibodies	>9 publications with DLL4 and Adenocarcinoma
Inflammation Antibodies	>9 publications with DLL4 and Inflammation
Lung Diseases Antibodies	>8 publications with DLL4 and Lung Diseases
Glioma Antibodies	>8 publications with DLL4 and Glioma
Breast Neoplasms Antibodies	>8 publications with DLL4 and Breast Neoplasms
Carcinoma, Squamous Cell Antibodies	>6 publications with DLL4 and Carcinoma, Squamous Cell

Organs/Tissues associated with DLL4 elisa kit

Organ/Tissue Name	Pubmed Publications
Vascular Antibodies	>162 publications with DLL4 and Vascular
Muscle Antibodies	>21 publications with DLL4 and Muscle
Eye Antibodies	>19 publications with DLL4 and Eye
Brain Antibodies	>19 publications with DLL4 and Brain
Lung Antibodies	>18 publications with DLL4 and Lung
Intestine Antibodies	>8 publications with DLL4 and Intestine
Placenta Antibodies	>7 publications with DLL4 and Placenta
Heart Antibodies	>7 publications with DLL4 and Heart
Kidney Antibodies	>4 publications with DLL4 and Kidney
Uterus Antibodies	>4 publications with DLL4 and Uterus