Plexin C1 (PLXNC1) ELISA Kit for Human

Name: Human PLXNC1 ELISA Kit; Plexin C1; MyBioSource
Brand: MyBioSource
SKU: MBS944227
Price: 295 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS944227

Principle of the assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for PLXNC1 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any PLXNC1 present is bound by the… More details

$295 / 24-Strip-Wells (LIMIT 1) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Request Current Manual

Product Overview

Online Datasheet in PDF

Product Name

plexin C1 (PLXNC1), ELISA Kit

Full Product Name

Human Plexin-C1, PLXNC1 ELISA Kit

Product Gene Name

PLXNC1 elisa kit

Product Synonym Names

Human Plexin-C1 (PLXNC1) ELISA kit; CD232; PLXN-C1; VESPR; plexin (semaphorin receptor) ; receptor for virally-encoded semaphorin; plexin C1

Species Reactivity

Human

Assay Type

Sandwich

Samples

Serum, plasma, tissue homogenates, Cell lysates

Detection Range

0.312 ng/ml -20 ng/ml.

Sensitivity

The minimum detectable dose of human PLXNC1 is typically less than 0.078 ng/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations.

Specificity

This assay has high sensitivity and excellent specificity for detection of human PLXNC1. No significant cross-reactivity or interference between human PLXNC1 and analogues was observed.

Preparation and Storage

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

Inter-assay Precision

Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.

Intra-assay Precision

Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess.

Molecular Weight

175,742 Da

OMIM

604259

3D Structure

ModBase 3D Structure for O60486

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of PLXNC1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PLXNC1 purchase

MBS944227 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the plexin C1 (PLXNC1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing PLXNC1. The ELISA analytical biochemical technique of the MBS944227 kit is based on PLXNC1 antibody-PLXNC1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PLXNC1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PLXNC1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for PLXNC1. It may not necessarily be applicable to this product.

NCBI GI #

5032223

NCBI GeneID

10154

NCBI Accession #

NP_005752.1

UniProt Primary Accession #

O60486

UniProt Secondary Accession #

Q59H25

UniProt Related Accession #

O60486

GenBank Nucleotide #

NM_005761.2

NCBI Official Full Name

plexin-C1

NCBI Official Synonym Full Names

plexin C1

NCBI Official Symbol

PLXNC1

NCBI Official Synonym Symbols

CD232; VESPR; PLXN-C1

UniProt Protein Name

Plexin-C1

UniProt Synonym Protein Names

Virus-encoded semaphorin protein receptor; CD_antigen: CD232

Protein Family

Plexin

UniProt Gene Name

PLXNC1

UniProt Synonym Gene Names

VESPR

UniProt Entry Name

PLXC1_HUMAN

NCBI Protein Information

plexin-C1; plexin (semaphorin receptor); receptor for viral semaphorin protein; receptor for virally-encoded semaphorin; virus-encoded semaphorin protein receptor

NCBI Summary for PLXNC1

This gene encodes a member of the plexin family. Plexins are transmembrane receptors for semaphorins, a large family of proteins that regulate axon guidance, cell motility and migration, and the immune response. The encoded protein and its ligand regulate melanocyte adhesion, and viral semaphorins may modulate the immune response by binding to this receptor. The encoded protein may be a tumor suppressor protein for melanoma. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2011]

UniProt Comments for PLXNC1

PLXNC1: Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8. Belongs to the plexin family.

Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 12q23.3

Cellular Component: membrane; plasma membrane; integral to membrane; intracellular

Molecular Function: protein binding; receptor activity; receptor binding

Biological Process: axon guidance; signal transduction; cell adhesion

Research Articles on PLXNC1

1. loss of Plexin C1 in melanoma may promote early steps in melanoma progression through suppression of migration and proliferation

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with PLXNC1 elisa kit

Products by Pathway	Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Developmental Biology Pathway antibodies	Developmental Biology Pathway Diagram
Other Semaphorin Interactions Pathway antibodies	Other Semaphorin Interactions Pathway Diagram
Semaphorin Interactions Pathway antibodies	Semaphorin Interactions Pathway Diagram

Diseases associated with PLXNC1 elisa kit

Disease Name	Pubmed Publications
Neoplasms Antibodies	>2 publications with PLXNC1 and Neoplasms
Leukemia, Myeloid Antibodies	>1 publications with PLXNC1 and Leukemia, Myeloid
Leukemia, Myeloid, Acute Antibodies	>1 publications with PLXNC1 and Leukemia, Myeloid, Acute
Pancreatic Neoplasms Antibodies	>1 publications with PLXNC1 and Pancreatic Neoplasms

Organs/Tissues associated with PLXNC1 elisa kit

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>1 publications with PLXNC1 and Lung
Mouth Antibodies	>1 publications with PLXNC1 and Mouth
Testis Antibodies	>1 publications with PLXNC1 and Testis
Embryonic Tissue Antibodies	>1 publications with PLXNC1 and Embryonic Tissue
Kidney Antibodies	>1 publications with PLXNC1 and Kidney
Brain Antibodies	>1 publications with PLXNC1 and Brain