Human TNFRSF6B ELISA Kit – Cat# MBS945617

Tumor Necrosis Factor Receptor Superfamily, Member 6b, Decoy (TNFRSF6B) ELISA Kit for Human

Name: Human TNFRSF6B ELISA Kit; MyBioSource
Brand: MyBioSource
SKU: MBS945617
Price: 295 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS945617

MBS945617 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the tumor necrosis factor receptor superfamily, member 6b, decoy (TNFRSF6B) ELISA Kit target analytes in biological samples. The… More details

$295 / 24-Strip-Wells (LIMIT 1) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

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Product Overview

Online Datasheet in PDF

Product Name

tumor necrosis factor receptor superfamily, member 6b, decoy (TNFRSF6B), ELISA Kit

Full Product Name

Human Tumor necrosis factor receptor superfamily member 6B, TNFRSF6B ELISA Kit

Product Gene Name

TNFRSF6B elisa kit

Product Synonym Names

Human Tumor necrosis factor receptor superfamily member 6B (TNFRSF6B) ELISA kit; hCG_2044836; DCR3; DJ583P15.1.1; M68; TR6; OTTHUMP00000031583; decoy receptor 3; tumor necrosis factor receptor superfamily; member 6b; tumor necrosis factor receptor superfamily; member 6b; decoy

Species Reactivity

Human

Samples

Serum, plasma, cell culture supernates

Detection Range

0.156 ng/ml-10 ng/ml

Sensitivity

0.039 ng/ml

Specificity

This assay has high sensitivity and excellent specificity for detection of Human TNFRSF6B. No significant cross-reactivity or interference between Human TNFRSF6B and analogues was observed.

Preparation and Storage

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

Intra-assay Precision

Intra-assay Precision (Precision within an assay): CV% is less than 8%
Three samples of known concentration were tested twenty times on one plate to assess.
Inter-assay Precision (Precision between assays): CV% is less than 10%
Three samples of known concentration were tested in twenty assays to assess.

Molecular Weight

32,680 Da

OMIM

603361

3D Structure

ModBase 3D Structure for O95407

Detection Wavelength

450 nm

Sample Volume

50-100ul

Protein Biological Process 1

Apoptosis/Autophagy

Protein Biological Process 3

Apoptosis

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of TNFRSF6B elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TNFRSF6B. It may not necessarily be applicable to this product.

NCBI GI #

4507585

NCBI GeneID

8771

NCBI Accession #

NP_003814.1

UniProt Primary Accession #

O95407

UniProt Related Accession #

O95407

GenBank Nucleotide #

NM_003823.3

NCBI Official Full Name

tumor necrosis factor receptor superfamily member 6B

NCBI Official Synonym Full Names

tumor necrosis factor receptor superfamily, member 6b, decoy

NCBI Official Symbol

TNFRSF6B

NCBI Official Synonym Symbols

M68; TR6; DCR3; M68E; DJ583P15.1.1

UniProt Protein Name

Tumor necrosis factor receptor superfamily member 6B

UniProt Synonym Protein Names

Decoy receptor 3; DcR3; Decoy receptor for Fas ligand; M68

Protein Family

Tumor necrosis factor receptor superfamily

UniProt Gene Name

TNFRSF6B

UniProt Synonym Gene Names

DCR3; TR6; UNQ186/PRO212; DcR3

UniProt Entry Name

TNF6B_HUMAN

NCBI Protein Information

tumor necrosis factor receptor superfamily member 6B; decoy receptor 3; decoy receptor for Fas ligand

NCBI Summary for TNFRSF6B

This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript. [provided by RefSeq, Feb 2011]

UniProt Comments for TNFRSF6B

TNFRSF6B: Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis. Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. Highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 20q13.3

Cellular Component: extracellular space

Molecular Function: protein binding; receptor activity

Biological Process: apoptosis; negative regulation of apoptosis

Research Articles on TNFRSF6B

1. our data strongly support the notion that tumor cells utilize binding of DcR3 to TRAIL to escape TRAIL-mediated apoptosis, an extracellular protection system for malignancy.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TNFRSF6B elisa kit

Reference Product	PubMed Publications
FASLG elisa kit	>20 publications with TNFRSF6B and FASLG
TNFSF14 elisa kit	>14 publications with TNFRSF6B and TNFSF14
TNFSF15 elisa kit	>10 publications with TNFRSF6B and TNFSF15

Pathways associated with TNFRSF6B elisa kit

Products by Pathway	Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram

Diseases associated with TNFRSF6B elisa kit

Disease Name	Pubmed Publications
Necrosis Antibodies	>107 publications with TNFRSF6B and Necrosis
Neoplasms Antibodies	>46 publications with TNFRSF6B and Neoplasms
Death Antibodies	>28 publications with TNFRSF6B and Death
Carcinoma Antibodies	>25 publications with TNFRSF6B and Carcinoma
Adenocarcinoma Antibodies	>20 publications with TNFRSF6B and Adenocarcinoma
Gastrointestinal Diseases Antibodies	>20 publications with TNFRSF6B and Gastrointestinal Diseases
Inflammation Antibodies	>11 publications with TNFRSF6B and Inflammation
Lung Neoplasms Antibodies	>7 publications with TNFRSF6B and Lung Neoplasms
Liver Neoplasms Antibodies	>7 publications with TNFRSF6B and Liver Neoplasms
Infection Antibodies	>6 publications with TNFRSF6B and Infection

Organs/Tissues associated with TNFRSF6B elisa kit

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>11 publications with TNFRSF6B and Lung
Kidney Antibodies	>6 publications with TNFRSF6B and Kidney
Stomach Antibodies	>6 publications with TNFRSF6B and Stomach
Vascular Antibodies	>4 publications with TNFRSF6B and Vascular
Brain Antibodies	>3 publications with TNFRSF6B and Brain
Skin Antibodies	>3 publications with TNFRSF6B and Skin
Pancreas Antibodies	>3 publications with TNFRSF6B and Pancreas
Bone Antibodies	>3 publications with TNFRSF6B and Bone
Spleen Antibodies	>3 publications with TNFRSF6B and Spleen
Ascites Antibodies	>2 publications with TNFRSF6B and Ascites