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ATP-Sensitive Inward Rectifier Potassium Channel 10 (KCNJ10) Rat Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS948201

MBS948201 is a recombinant protein targeting Kcnj10. Also known as Recombinant Rat ATP-sensitive inward rectifier potassium channel 10 (Kcnj10). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ATP-sensitive inward rectifier potassium channel 10 (Kcnj10), Recombinant Protein
Full Product Name
Recombinant Rat ATP-sensitive inward rectifier potassium channel 10 (Kcnj10)
Product Gene Name
Kcnj10 recombinant protein
Product Synonym Gene Name
Kcnj10; Kab-2
Product Synonym Names
Recombinant ATP-sensitive inward rectifier potassium channel 10 (Kcnj10); ATP-sensitive inward rectifier potassium channel 10; ATP-sensitive inward rectifier potassium channel KAB-2 BIR10 Brain-specific inwardly rectifying K(+) channel 1; BIRK1 Inward rec
Sequence
MTSVAKVYYS QTTQTESRPL VAPGIRRRRV LTKDGRSNVR MEHIADKRFL YLKDLWTTFI DMQWRYKLLL FSATFAGTWF LFGVVWYLVA VAHGDLLELG PPANHTPCVV QVHTLTGAFL FSLESQTTIG YGFRYISEEC PLAIVLLIAQ LVLTTILEIF ITGTFLAKIA RPKKRAETIR FSQHAVVAYH NGKLCLMIRV ANMRKSLLIG CQVTGKLLQT HQTKEGENIR LNQVNVTFQV DTASDSPFLI LPLTFYHVVD ETSPLKDLPL RSGEGDFELV LILSGTVEST SATCQVRTSY LPEEILWGYE FTPAISLSAS GKYVADFSLF DQVVKVASPG GLRDSTVRYG DPEKLKLEES LREQAEKEGS ALSVRISNV
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
Molecular Weight
42,480 Da
Sequence Positions
1-379
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Chromosome Location
Chromosome: 13; NC_005112.3 (95245046..95274535). Location: 13q24
3D Structure
ModBase 3D Structure for P49655
Species
Rattus norvegicus (Rat)
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Kcnj10 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Kcnj10. It may not necessarily be applicable to this product.

NCBI GI #
13928822
NCBI GeneID
29718
NCBI Accession #
NP_113790.1
UniProt Primary Accession #
P49655
UniProt Secondary Accession #
Q62790
UniProt Related Accession #
P49655
GenBank Nucleotide #
NM_031602.1
NCBI Official Full Name
ATP-sensitive inward rectifier potassium channel 10
NCBI Official Synonym Full Names
potassium inwardly-rectifying channel, subfamily J, member 10
NCBI Official Symbol
Kcnj10
UniProt Protein Name
ATP-sensitive inward rectifier potassium channel 10
UniProt Synonym Protein Names
ATP-sensitive inward rectifier potassium channel KAB-2; BIR10; Brain-specific inwardly rectifying K(+) channel 1; BIRK1; Inward rectifier K(+) channel Kir4.1; Potassium channel, inwardly rectifying subfamily J member 10
Protein Family
ATP-sensitive inward rectifier potassium channel
UniProt Gene Name
Kcnj10
UniProt Synonym Gene Names
Kab-2; BIRK1
UniProt Entry Name
IRK10_RAT
NCBI Protein Information
ATP-sensitive inward rectifier potassium channel 10; BIR10; BIRK1; kir4.1; inward rectifier K(+) channel Kir4.1; brain-specific inwardly rectifying K(+) channel 1; ATP-sensitive inward rectifier potassium channel KAB-2; potassium channel, inwardly rectifying subfamily J member 10

NCBI Summary for Kcnj10

inwardly rectifying K+ channel; specifically expressed in brain [RGD, Feb 2006]

UniProt Comments for Kcnj10

Kir4.1: May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium. Defects in KCNJ10 are the cause of seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance (SESAMES). A complex disorder characterized by generalized seizures with onset in infancy, delayed psychomotor development, ataxia, sensorineural hearing loss, hypokalemia, metabolic alkalosis, and hypomagnesemia. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ10 subfamily.

Protein type: Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: microvillus; integral to plasma membrane; basolateral plasma membrane; apical plasma membrane; plasma membrane

Molecular Function: identical protein binding; protein binding; potassium channel activity; ATP-activated inward rectifier potassium channel activity; inward rectifier potassium channel activity; ATP binding; receptor binding

Biological Process: regulation of long-term neuronal synaptic plasticity; myelination in the central nervous system; response to glucocorticoid stimulus; membrane hyperpolarization; response to blue light; glutamate uptake during transmission of nerve impulse; response to mineralocorticoid stimulus; adult walking behavior; protein homotetramerization; L-glutamate import; regulation of membrane potential; potassium ion import; visual perception; optic nerve development; regulation of resting membrane potential; regulation of sensory perception of pain; inflammatory response; oligodendrocyte development; potassium ion homeostasis; potassium ion transport
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Research Articles on Kcnj10

1. Kir4.1 channels in satellite glial cells are suppressed during trigeminal inflammatory pain.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Kcnj10 recombinant protein

 Products by Pathway  Pathway Diagram
 Activation Of G Protein Gated Potassium Channels Pathway antibodies  Activation Of G Protein Gated Potassium Channels Pathway Diagram
 Activation Of GABAB Receptors Pathway antibodies  Activation Of GABAB Receptors Pathway Diagram
 G Protein Gated Potassium Channels Pathway antibodies  G Protein Gated Potassium Channels Pathway Diagram
 GABA B Receptor Activation Pathway antibodies  GABA B Receptor Activation Pathway Diagram
 GABA Receptor Activation Pathway antibodies  GABA Receptor Activation Pathway Diagram
 Gastric Acid Secretion Pathway antibodies  Gastric Acid Secretion Pathway Diagram
 Gastric Acid Secretion Pathway antibodies  Gastric Acid Secretion Pathway Diagram
 Inhibition Of Voltage Gated Ca2+ Channels Via Gbeta/gamma Subunits Pathway antibodies  Inhibition Of Voltage Gated Ca2+ Channels Via Gbeta/gamma Subunits Pathway Diagram
 Inwardly Rectifying K+ Channels Pathway antibodies  Inwardly Rectifying K+ Channels Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram

Diseases associated with Kcnj10 recombinant protein

 Disease Name  Pubmed Publications
 Hearing Disorders Antibodies  >22 publications with Kcnj10 and Hearing Disorders
 Congenital Abnormalities Antibodies  >9 publications with Kcnj10 and Congenital Abnormalities
 Kidney Diseases Antibodies  >7 publications with Kcnj10 and Kidney Diseases
 Hypokalemia Antibodies  >3 publications with Kcnj10 and Hypokalemia
 SEIZURES, SENSORINEURAL DEAFNESS, ATAXIA, MENTAL RETARDATION, AND ELECTROLYTE IMBALANCE Antibodies  >3 publications with Kcnj10 and SEIZURES, SENSORINEURAL DEAFNESS, ATAXIA, MENTAL RETARDATION, AND ELECTROLYTE IMBALANCE
 Nerve Degeneration Antibodies  >2 publications with Kcnj10 and Nerve Degeneration
 Acidosis Antibodies  >2 publications with Kcnj10 and Acidosis
 Diabetes Mellitus Antibodies  >1 publications with Kcnj10 and Diabetes Mellitus
 Bone Diseases Antibodies  >1 publications with Kcnj10 and Bone Diseases
 Nervous System Malformations Antibodies  >1 publications with Kcnj10 and Nervous System Malformations

Organs/Tissues associated with Kcnj10 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >14 publications with Kcnj10 and Brain
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