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Pituitary Adenylate Cyclase-Activating Polypeptide Type Ia Receptor (ADCYAP1R1) Rat Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS948274

MBS948274 is a recombinant protein targeting Adcyap1r1. Also known as Recombinant Rat Pituitary adenylate cyclase-activating polypeptide type IA receptor (Adcyap1r1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Pituitary adenylate cyclase-activating polypeptide type IA receptor (Adcyap1r1), Recombinant Protein
Full Product Name
Recombinant Rat Pituitary adenylate cyclase-activating polypeptide type IA receptor (Adcyap1r1)
Product Gene Name
Adcyap1r1 recombinant protein
Product Synonym Gene Name
Adcyap1r1
Product Synonym Names
Recombinant Pituitary adenylate cyclase-activating polypeptide type IA receptor (Adcyap1r1); Pituitary adenylate cyclase-activating polypeptide type IA receptor; PACAP type IA receptor; PACAP-R-1A; PACAP-R1A
Sequence
MHSDCIFKKE QAMCLERIQR ANDLMGLNES SPGCPGMWDN ITCWKPAQVG EMVLVSCPEV FRIFNPDQVW MTETIGDSGF ADSNSLEITD MGVVGRNCTE DGWSEPFPHY FDACGFDDYE PESGDQDYYY LSVKALYTVG YSTSLATLTT AMVILCRFRK LHCTRNFIHM NLFVSFMLRA ISVFIKDWIL YAEQDSSHCF VSTVECKAVM VFFHYCVVSN YFWLFIEGLY LFTLLVETFF PERRYFYWYT IIGWGTPTVC VTVWAVLRLY FDDAGCWDMN DSTALWWVIK GPVVGSIMVN FVLFIGIIII LVQKLQSPDM GGNESSIYLT NLRLRVPKKT REDPLPVPSD QHSPPFLSCV QKCYCKPQRA QQHSCKMSEL STITLRLARS TLLLIPLFGI HYTVFAFSPE NVSKRERLVF ELGLGSFQGF VVAVLYCFLN GEVQAEIKRK WRSWKVNRYF TMDFKHRHPS LASSGVNGGT QLSILSKSSS QLRMSSLPAD NLAT
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
Molecular Weight
59,637 Da
Sequence Positions
20-523
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Chromosome Location
Chromosome: 4; NC_005103.3 (150314846..150360099). Location: 4q24
3D Structure
ModBase 3D Structure for P32215
Species
Rattus norvegicus (Rat)
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Adcyap1r1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Adcyap1r1. It may not necessarily be applicable to this product.

NCBI GI #
396080323
NCBI GeneID
24167
NCBI Accession #
NP_001257508.1
UniProt Primary Accession #
P32215
UniProt Secondary Accession #
Q63414
UniProt Related Accession #
P32215
GenBank Nucleotide #
NM_001270579.1
NCBI Official Full Name
pituitary adenylate cyclase-activating polypeptide type I receptor isoform a
NCBI Official Synonym Full Names
adenylate cyclase activating polypeptide 1 receptor 1
NCBI Official Symbol
Adcyap1r1
NCBI Official Synonym Symbols
PAC1-R; PACAPR1; PACAP-R1; PACAPR1A; PACAP-R1A
UniProt Protein Name
Pituitary adenylate cyclase-activating polypeptide type I receptor
Protein Family
Pituitary adenylate cyclase-activating polypeptide type I receptor
UniProt Gene Name
Adcyap1r1
UniProt Synonym Gene Names
PACAP type I receptor; PACAP-R-1; PACAP-R1
UniProt Entry Name
PACR_RAT
NCBI Protein Information
pituitary adenylate cyclase-activating polypeptide type I receptor; PACAP-R-1; PACAP-R-1A; PACAP type I receptor; PACAP type IA receptor; adenylate cyclase activating polypeptide 1 type 1 receptor; pituitary adenylate cyclase activating polypeptide receptor; pituitary adenylate cyclase activating polypeptide 1 receptor (1); pituitary adenylate cyclase-activating polypeptide type IA receptor; adenylate cyclase activating polypeptide 1 (pituitary) receptor type I

NCBI Summary for Adcyap1r1

regulates neural precursor proliferation; mediates inhibitory signaling for Shh-induced cerebellar granule precursor cell proliferation [RGD, Feb 2006]

UniProt Comments for Adcyap1r1

ADCYAP1R1: This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract. Belongs to the G-protein coupled receptor 2 family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Cellular Component: Golgi membrane; neuron projection; cell surface; tight junction; rough endoplasmic reticulum; cytoplasm; integral to membrane; caveola; endosome; receptor complex

Molecular Function: neuropeptide binding; ADP-ribosylation factor binding; vasoactive intestinal polypeptide receptor activity; adenylate cyclase binding

Biological Process: response to drug; development of primary female sexual characteristics; G-protein coupled receptor protein signaling pathway; cAMP-mediated signaling; response to ethanol; phospholipase C activation; positive regulation of cAMP biosynthetic process; spermatogenesis; cell differentiation; multicellular organismal response to stress; response to estradiol stimulus
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Research Articles on Adcyap1r1

1. PACAP causes PAC1/VPAC2 receptor mediated hypertension and sympathoexcitation in normal and hypertensive rats.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Adcyap1r1 recombinant protein

 Products by Pathway  Pathway Diagram
 Activation Of TRKA Receptors Pathway antibodies  Activation Of TRKA Receptors Pathway Diagram
 GPCRs, Class B Secretin-like Pathway antibodies  GPCRs, Class B Secretin-like Pathway Diagram
 NGF Signalling Via TRKA From The Plasma Membrane Pathway antibodies  NGF Signalling Via TRKA From The Plasma Membrane Pathway Diagram
 NGF-independant TRKA Activation Pathway antibodies  NGF-independant TRKA Activation Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 SIDS Susceptibility Pathways antibodies  SIDS Susceptibility Pathways Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signalling By NGF Pathway antibodies  Signalling By NGF Pathway Diagram

Diseases associated with Adcyap1r1 recombinant protein

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >20 publications with Adcyap1r1 and Neoplasms
 Lung Neoplasms Antibodies  >6 publications with Adcyap1r1 and Lung Neoplasms
 Gastrointestinal Diseases Antibodies  >6 publications with Adcyap1r1 and Gastrointestinal Diseases
 Inflammation Antibodies  >5 publications with Adcyap1r1 and Inflammation
 Drug Toxicity Antibodies  >3 publications with Adcyap1r1 and Drug Toxicity
 Hypertrophy Antibodies  >2 publications with Adcyap1r1 and Hypertrophy
 Necrosis Antibodies  >2 publications with Adcyap1r1 and Necrosis
 Liver Diseases Antibodies  >2 publications with Adcyap1r1 and Liver Diseases
 Liver Neoplasms, Experimental Antibodies  >2 publications with Adcyap1r1 and Liver Neoplasms, Experimental
 Ischemia Antibodies  >2 publications with Adcyap1r1 and Ischemia

Organs/Tissues associated with Adcyap1r1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >68 publications with Adcyap1r1 and Brain
 Pituitary Gland Antibodies  >24 publications with Adcyap1r1 and Pituitary Gland
 Uncharacterized Tissue Antibodies  >1 publications with Adcyap1r1 and Uncharacterized Tissue
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