Human NANOS2 Recombinant Protein – Cat# MBS948297

Nanos Homolog 2 (NANOS2) Human Recombinant Protein

Name: NANOS2 Recombinant Protein; Nanos Homolog 2; Human; MyBioSource
Brand: MyBioSource
SKU: MBS948297
Price: 385 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS948297

Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the fale fate. Represses the fale fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression… More details

$385 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Nanos homolog 2 (NANOS2), Recombinant Protein

Full Product Name

Recombinant Human Nanos homolog 2

Product Gene Name

NANOS2 recombinant protein

Sequence

MQLPPFDMWK DYFNLSQVVW ALIASRGQRL ETQEIEEPSP GPPLGQDQGL GAPGANGGLG TLCNFCKHNG ESRHVYSSHQ LKTPDGVVVC PILRHYVCPV CGATGDQAHT LKYCPLNGGQ QSLYRRSGRN SAGRRVKR

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

Molecular Weight

31.1 kDa

Sequence Positions

1-138aa; Full Length

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

608228

3D Structure

ModBase 3D Structure for P60321

Product Categories/Family for NANOS2 recombinant protein

Epigenetics and Nuclear Signaling

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of NANOS2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NANOS2 purchase

MBS948297 is a recombinant protein targeting NANOS2. Also known as Recombinant Human Nanos homolog 2. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for NANOS2. It may not necessarily be applicable to this product.

NCBI GI #

71143121

NCBI GeneID

339345

NCBI Accession #

NP_001025032.1

UniProt Primary Accession #

P60321

UniProt Secondary Accession #

Q17R30; Q4G0P8

UniProt Related Accession #

P60321

GenBank Nucleotide #

NM_001029861.2

NCBI Official Full Name

nanos homolog 2

NCBI Official Synonym Full Names

nanos homolog 2 (Drosophila)

NCBI Official Symbol

NANOS2

NCBI Official Synonym Symbols

NOS2

UniProt Protein Name

Nanos homolog 2

Protein Family

Nanos

UniProt Gene Name

NANOS2

UniProt Synonym Gene Names

NOS2; NOS-2

UniProt Entry Name

NANO2_HUMAN

NCBI Protein Information

nanos homolog 2

UniProt Comments for NANOS2

NANOS2: Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state. Belongs to the nanos family.

Chromosomal Location of Human Ortholog: 19q13.32

Cellular Component: cytoplasm; nucleus; perinuclear region of cytoplasm

Molecular Function: mRNA binding; protein binding; zinc ion binding

Biological Process: cell differentiation; germ-line stem cell maintenance; mRNA catabolic process; multicellular organismal development; negative regulation of meiosis; negative regulation of translation; spermatogenesis

Research Articles on NANOS2

1. Data describe for the first time the expression pattern of the NANOS2 gene in human tissues and show that it is testis specific. We found that NANOS2 protein is present in prenatal germ cells and at later stages in spermatogenesis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with NANOS2 recombinant protein

Reference Product	PubMed Publications
STRA8 recombinant protein	>15 publications with NANOS2 and STRA8
CYP26B1 recombinant protein	>7 publications with NANOS2 and CYP26B1
FGF9 recombinant protein	>6 publications with NANOS2 and FGF9
ZBTB16 recombinant protein	>3 publications with NANOS2 and ZBTB16
PUM2 recombinant protein	>2 publications with NANOS2 and PUM2
DDX4 recombinant protein	>1 publications with NANOS2 and DDX4
DAZL recombinant protein	>1 publications with NANOS2 and DAZL

Diseases associated with NANOS2 recombinant protein

Disease Name	Pubmed Publications
Male Urogenital Diseases Antibodies	>4 publications with NANOS2 and Male Urogenital Diseases
Infertility, Male Antibodies	>3 publications with NANOS2 and Infertility, Male
Testicular Diseases Antibodies	>2 publications with NANOS2 and Testicular Diseases
Oligospermia Antibodies	>1 publications with NANOS2 and Oligospermia
Cell Transformation, Neoplastic Antibodies	>1 publications with NANOS2 and Cell Transformation, Neoplastic
Growth Disorders Antibodies	>1 publications with NANOS2 and Growth Disorders
Urogenital Abnormalities Antibodies	>1 publications with NANOS2 and Urogenital Abnormalities
Genital Diseases, Female Antibodies	>1 publications with NANOS2 and Genital Diseases, Female

Organs/Tissues associated with NANOS2 recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>2 publications with NANOS2 and Brain