• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Pyridoxal Phosphate Phosphatase (PDXP) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS949456

Protein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal… More details

$315 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Pyridoxal phosphate phosphatase (Pdxp), Recombinant Protein
Full Product Name
Recombinant Mouse Pyridoxal phosphate phosphatase (Pdxp)
Product Gene Name
Pdxp recombinant protein
Product Synonym Gene Name
Pdxp; Cin; Plp; Plpp
Product Synonym Names
Pyridoxal phosphate phosphatase; PLP phosphatase; EC=3.1.3.3; EC=3.1.3.74; Chronophin
Sequence
MARCERLRGA ALRDVLGQAQ GVLFDCDGVL WNGERIVPGA PELLQRLARA GKNTLFVSNN SRRARPELAL RFARLGFAGL RAEQLFSSAL CAARLLRQRL SGPPDASGAV FVLGGEGLRA ELRAAGLRLA GDPGEDPRVR AVLVGYDEQF SFSRLTEACA HLRDPDCLLV ATDRDPWHPL SDGSRTPGTG SLAAAVETAS GRQALVVGKP SPYMFQCITE DFSVDPARTL MVGDRLETDI LFGHRCGMTT VLTLTGVSSL EEAQAYLTAG QRDLVPHYYV ESIADLMEGL ED
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
33.5 kDa
Sequence Positions
1-292aa; Full Length
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for P60487
Species
Mus musculus (Mouse)
Production Note
Special Offer: The E Coli, Yeast host-expressed protein is manufactured from a stock plasmid containing the protein gene. E Coli, Yeasthost-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The E Coli, Yeast host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select E Coli, Yeast host-expressed protein for the fastest delivery among all hosts. Please contact our technical support team or email to support@mybiosource.com for more details.

Product Categories/Family for Pdxp recombinant protein

Signal Transduction
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

SDS-Page of Pdxp recombinant protein

Mouse PDXP Recombinant Protein – Cat# MBS949456

Other Notes

Small volumes of Pdxp recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Pdxp purchase

MBS949456 is a recombinant protein targeting Pdxp. Also known as Recombinant Mouse Pyridoxal phosphate phosphatase (Pdxp). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Pdxp. It may not necessarily be applicable to this product.

NCBI GI #
47059486
NCBI GeneID
57028
NCBI Accession #
NP_064667.2
UniProt Primary Accession #
P60487
UniProt Related Accession #
P60487
GenBank Nucleotide #
NM_020271.3
NCBI Official Full Name
pyridoxal phosphate phosphatase
NCBI Official Synonym Full Names
pyridoxal (pyridoxine, vitamin B6) phosphatase
NCBI Official Symbol
Pdxp
NCBI Official Synonym Symbols
PLPP; AB041662; 1600027H05Rik
UniProt Protein Name
Pyridoxal phosphate phosphatase
UniProt Synonym Protein Names
Chronophin
Protein Family
Pyridoxal phosphate phosphatase
UniProt Gene Name
Pdxp
UniProt Synonym Gene Names
Cin; Plp; Plpp; PLP phosphatase
UniProt Entry Name
PLPP_MOUSE
NCBI Protein Information
pyridoxal phosphate phosphatase; chronophin; chronophilin; PLP phosphatase; PLP-phosophatase

UniProt Comments for Pdxp

PDXP: Protein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho- tyrosine. Pyridoxal phosphate phosphatase. Has some activity towards pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PMP) and pyridoxine 5'-phosphate (PNP), with a highest activity with PLP followed by PNP. Homodimer. Ubiquitous. Highly expressed in all the regions of central nerve system except the spinal cord. Also expressed at high level in liver and testis. In fetus, it is weakly expressed in all organs except brain. Inhibited by NaF, Zn(2+), Ca(2+), Mn(2+) and EDTA. Belongs to the HAD-like hydrolase superfamily.

Protein type: Cofactor and Vitamin Metabolism - vitamin B6; EC 3.1.3.74; Cell cycle regulation; EC 3.1.3.3; Protein phosphatase, Ser/Thr (non-receptor)

Cellular Component: lamellipodium; plasma membrane; intercellular junction; midbody; cytosol; cleavage furrow; actin cytoskeleton

Molecular Function: heat shock protein binding; phosphoprotein phosphatase activity

Biological Process: actin rod formation; positive regulation of actin filament depolymerization; regulation of mitosis; protein amino acid dephosphorylation; regulation of cytokinesis
Show more

Research Articles on Pdxp

1. Dimer formation is essential for an intermolecular arginine-arginine-tryptophan stacking interaction that positions a critical histidine residue in the substrate specificity loop of chronophin for PLP coordination.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Pdxp recombinant protein

 Products by Pathway  Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Vitamin B6 Metabolism Pathway antibodies  Vitamin B6 Metabolism Pathway Diagram
 Vitamin B6 Metabolism Pathway antibodies  Vitamin B6 Metabolism Pathway Diagram

Diseases associated with Pdxp recombinant protein

 Disease Name  Pubmed Publications
 Lung Neoplasms Antibodies  >3 publications with Pdxp and Lung Neoplasms
 Inflammation Antibodies  >1 publications with Pdxp and Inflammation

Organs/Tissues associated with Pdxp recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >3 publications with Pdxp and Lung
 Liver Antibodies  >1 publications with Pdxp and Liver
 Brain Antibodies  >1 publications with Pdxp and Brain
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000