Hexokinase-1 (HK1) Human Recombinant Protein

MBS949694 is a recombinant protein targeting HK1. Also known as Recombinant Human Hexokinase-1. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Human hexokinase sequences of amino- and carboxyl-terminal halves are homologous.Nishi S., Seino S., Bell G.I.Biochem. Biophys. Res. Commun. 157:937-943(1988) Structure of the human hexokinase type I gene and nucleotide sequence of the 5' flanking region.Ruzzo A., Andreoni F., Magnani M.Biochem. J. 331:607-613(1998) The DNA sequence and comparative analysis of human chromosome 10.Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.Nature 429:375-381(2004) Structure of the 5' region of the human hexokinase type I (HKI) gene and identification of an additional testis-specific HKI mRNA.Andreoni F., Ruzzo A., Magnani M.Biochim. Biophys. Acta 1493:19-26(2000) The erythrocyte-specific hexokinase isozyme (HKR) and the common hexokinase isozyme (HKI) are produced from a single gene by alternate promoters.Murakami K., Piomelli S.Blood 90:272-272(1998) Bienvenut W.V., Waridel P., Quadroni M.Submitted (MAR-2009) to UniProtKB Human hexokinase type I microheterogeneity is due to different amino-terminal sequences.Magnani M., Serafini G., Bianchi M., Casabianca A., Stocchi V.J. Biol. Chem. 266:502-505(1991) A recombinant human 'mini'-hexokinase is catalytically active and regulated by hexose 6-phosphates.Magnani M., Bianchi M., Casabianca A., Stocchi V., Daniele A., Altruda F., Ferrone M., Silengo L.Biochem. J. 285:193-199(1992) Identification of the cDNA for human red blood cell-specific hexokinase isozyme.Murakami K., Piomelli S.Blood 89:762-766(1997) Crystallization and preliminary X-ray analysis of human brain hexokinase.Aleshin A.E., Zeng C., Fromm H.J., Honatko R.B.FEBS Lett. 391:9-10(1996) Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.Anal. Chem. 81:4493-4501(2009) A mutation in an alternative untranslated exon of hexokinase 1 associated with hereditary motor and sensory neuropathy -- Russe (HMSNR) .Hantke J., Chandler D., King R., Wanders R.J., Angelicheva D., Tournev I., McNamara E., Kwa M., Guergueltcheva V., Kaneva R., Baas F., Kalaydjieva L.Eur. J. Hum. Genet. 17:1606-1614(2009) Initial characterization of the human central proteome.Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.BMC Syst. Biol. 5:17-17(2011) PKCepsilon promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria.Lau E., Kluger H., Varsano T., Lee K., Scheffler I., Rimm D.L., Ideker T., Ronai Z.A.Cell 148:543-555(2012) The mechanism of regulation of hexokinase new insights from the crystal structure of recombinant human brain hexokinase complexed with glucose and glucose-6-phosphate.Aleshin A.E., Zeng C., Bourenkov G.P., Bartunik H.D., Fromm H.J., Honzatko R.B.Structure 6:39-50(1998) Regulation of hexokinase I crystal structure of recombinant human brain hexokinase complexed with glucose and phosphate.Aleshin A.E., Zeng C., Bartunik H.D., Fromm H.J., Honzatko R.B.J. Mol. Biol. 282:345-357(1998) Binding of non-catalytic ATP to human hexokinase I highlights the structural components for enzyme-membrane association control.Rosano C., Sabini E., Rizzi M., Deriu D., Murshudov G., Bianchi M., Serafini G., Magnani M., Bolognesi M.Structure 7:1427-1437(1999) Crystal structures of mutant monomeric hexokinase I reveal multiple ADP binding sites and conformational changes relevant to allosteric regulation.Aleshin A.E., Kirby C., Liu X., Bourenkov G.P., Bartunik H.D., Fromm H.J., Honzatko R.B.J. Mol. Biol. 296:1001-1015(2000) Hexokinase mutations that produce nonspherocytic hemolytic anemia.Bianchi M., Magnani M.Blood Cells Mol. Dis. 21:2-8(1995) HK Utrecht missense mutation in the active site of human hexokinase associated with hexokinase deficiency and severe nonspherocytic hemolytic anemia.van Wijk R., Rijksen G., Huizinga E.G., Nieuwenhuis H.K., van Solinge W.W.Blood 101:345-347(2003)

Small volumes of HK1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.