Human GALR1 Recombinant Protein – Cat# MBS949772

Galanin Receptor Type 1 (GALR1) Human Recombinant Protein

Name: GALR1 Recombinant Protein; Galanin Receptor Type 1; Human; MyBioSource
Brand: MyBioSource
SKU: MBS949772
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS949772

MBS949772 is a recombinant protein targeting GALR1. Also known as Recombinant Human Galanin receptor type 1 (GALR1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Galanin receptor type 1 (GALR1), Recombinant Protein

Full Product Name

Recombinant Human Galanin receptor type 1 (GALR1)

Product Gene Name

GALR1 recombinant protein

Product Synonym Gene Name

GALR1; GALNR, GALNR1

Product Synonym Names

Recombinant Galanin receptor type 1 (GALR1); Galanin receptor type 1; GAL1-R; GALR-1

Sequence

MELAVGNLSE GNASWPEPPA PEPGPLFGIG VENFVTLVVF GLIFALGVLG NSLVITVLAR SKPGKPRSTT NLFILNLSIA DLAYLLFCIP FQATVYALPT WVLGAFICKF IHYFFTVSML VSIFTLAAMS VDRYVAIVHS RRSSSLRVSR NALLGVGCIW ALSIAMASPV AYHQGLFHPR ASNQTFCWEQ WPDPRHKKAY VVCTFVFGYL LPLLLICFCY AKVLNHLHKK LKNMSKKSEA SKKKTAQTVL VVVVVFGISW LPHHIIHLWA EFGVFPLTPA SFLFRITAHC LAYSNSSVNP IIYAFLSENF RKAYKQVFKC HIRKDSHLSD TKESKSRIDT PPSTNCTHV

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

Molecular Weight

38,953 Da

Sequence Positions

1-349

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

Chromosome Location

Chromosome: 18; NC_000018.9 (74962008..74982098). Location: 18q23

OMIM

600377

3D Structure

ModBase 3D Structure for P47211

Species

Homo sapiens (Human)

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of GALR1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GALR1. It may not necessarily be applicable to this product.

NCBI GI #

167000885

NCBI GeneID

2587

NCBI Accession #

NP_001471.2

UniProt Primary Accession #

P47211

UniProt Secondary Accession #

Q4VBL7

UniProt Related Accession #

P47211

GenBank Nucleotide #

NM_001480.3

NCBI Official Full Name

galanin receptor type 1

NCBI Official Synonym Full Names

galanin receptor 1

NCBI Official Symbol

GALR1

NCBI Official Synonym Symbols

GALNR; GALNR1

UniProt Protein Name

Galanin receptor type 1

Protein Family

Galanin receptor

UniProt Gene Name

GALR1

UniProt Synonym Gene Names

GALNR; GALNR1; GAL1-R; GALR-1

UniProt Entry Name

GALR1_HUMAN

NCBI Protein Information

galanin receptor type 1; GAL1-R; GALR-1

NCBI Summary for GALR1

The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-transmembrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart. [provided by RefSeq, Jul 2008]

UniProt Comments for GALR1

GALR1: Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1

Chromosomal Location of Human Ortholog: 18q23

Cellular Component: plasma membrane; integral to membrane

Molecular Function: neuropeptide binding; protein binding; peptide hormone binding; galanin receptor activity

Biological Process: elevation of cytosolic calcium ion concentration; positive regulation of cortisol secretion; neuropeptide signaling pathway; digestion; negative regulation of adenylate cyclase activity; positive regulation of transcription from RNA polymerase II promoter; G-protein signaling, adenylate cyclase activating pathway

Research Articles on GALR1

1. Genetic variants in the GALR1 gene are associated with a protective effect in nicotine dependence.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GALR1 recombinant protein

Reference Product	PubMed Publications
GAL recombinant protein	>45 publications with GALR1 and GAL

Pathways associated with GALR1 recombinant protein

Products by Pathway	Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
G Alpha (i) Signalling Events Pathway antibodies	G Alpha (i) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
GPCRs, Class A Rhodopsin-like Pathway antibodies	GPCRs, Class A Rhodopsin-like Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
Peptide GPCRs Pathway antibodies	Peptide GPCRs Pathway Diagram
Peptide Ligand-binding Receptors Pathway antibodies	Peptide Ligand-binding Receptors Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram

Diseases associated with GALR1 recombinant protein

Disease Name	Pubmed Publications
Pain Antibodies	>28 publications with GALR1 and Pain
Seizures Antibodies	>19 publications with GALR1 and Seizures
Mental Disorders Antibodies	>13 publications with GALR1 and Mental Disorders
Inflammation Antibodies	>8 publications with GALR1 and Inflammation
Death Antibodies	>6 publications with GALR1 and Death
Disease Models, Animal Antibodies	>6 publications with GALR1 and Disease Models, Animal
Neurodegenerative Diseases Antibodies	>5 publications with GALR1 and Neurodegenerative Diseases
Hyperalgesia Antibodies	>4 publications with GALR1 and Hyperalgesia
Melanoma Antibodies	>4 publications with GALR1 and Melanoma
Necrosis Antibodies	>4 publications with GALR1 and Necrosis

Organs/Tissues associated with GALR1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>96 publications with GALR1 and Brain
Nerve Antibodies	>32 publications with GALR1 and Nerve
Prostate Antibodies	>2 publications with GALR1 and Prostate