Rabbit FKBP1A Recombinant Protein – Cat# MBS949876

Peptidyl-Prolyl Cis-Trans Isomerase FKBP1A (FKBP1A) Rabbit Recombinant Protein

Name: FKBP1A Recombinant Protein; Rabbit; MyBioSource
Brand: MyBioSource
SKU: MBS949876
Price: 730 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS949876

This protein is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and… More details

$730 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A), Recombinant Protein

Full Product Name

Recombinant Rabbit Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A)

Product Gene Name

FKBP1A recombinant protein

Sequence

GVQVETISPG DGRTFPKRGQ TCVVHYTGML EDGKKFDSSR DRNKPFKFML GKQEVIRGWE EGVAQMSVGQ RAKLTISPDY AYGATGHPGI IPPHATLVFD VELLKLE

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

11,951 Da

Sequence Positions

2-108, Full length protein

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

3D Structure

ModBase 3D Structure for P62943

Species

Rabbit

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of FKBP1A recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FKBP1A purchase

MBS949876 is a recombinant protein targeting FKBP1A. Also known as Recombinant Rabbit Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for FKBP1A. It may not necessarily be applicable to this product.

NCBI GI #

283837823

NCBI GeneID

100328942

NCBI Accession #

NP_001164597.1

UniProt Primary Accession #

P62943

UniProt Secondary Accession #

P20071; Q9H103; Q9H566

UniProt Related Accession #

P62943

GenBank Nucleotide #

NM_001171126.1

NCBI Official Full Name

peptidyl-prolyl cis-trans isomerase FKBP1A

NCBI Official Symbol

FKBP1A

NCBI Official Synonym Symbols

FKBP1; FKBP12; FKBP-12; FKBP-1A; Rotamase

UniProt Protein Name

Peptidyl-prolyl cis-trans isomerase FKBP1A

UniProt Synonym Protein Names

12 kDa FK506-binding protein; 12 kDa FKBP; FKBP-12; Calstabin-1; FK506-binding protein 1A; FKBP-1A; Immunophilin FKBP12; Rotamase

Protein Family

Peptidyl-prolyl cis-trans isomerase

UniProt Gene Name

FKBP1A

UniProt Synonym Gene Names

FKBP1; FKBP12; PPIase FKBP1A; 12 kDa FKBP; FKBP-12; FKBP-1A

NCBI Protein Information

peptidyl-prolyl cis-trans isomerase FKBP1A

UniProt Comments for FKBP1A

Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides ().

Research Articles on FKBP1A

1. Data indicate that S107 increased FKBP12 binding to RyR1 in sarcoplasmic reticulum vesicles in the presence of reduced glutathione and the NO-donor NOC12.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with FKBP1A recombinant protein

Disease Name	Pubmed Publications
Muscular Diseases Antibodies	>3 publications with FKBP1A and Muscular Diseases
Neoplasms Antibodies	>3 publications with FKBP1A and Neoplasms
Inflammation Antibodies	>2 publications with FKBP1A and Inflammation
Nervous System Diseases Antibodies	>2 publications with FKBP1A and Nervous System Diseases
Hypertension Antibodies	>1 publications with FKBP1A and Hypertension
Acute Kidney Injury Antibodies	>1 publications with FKBP1A and Acute Kidney Injury
Urinary Bladder Diseases Antibodies	>1 publications with FKBP1A and Urinary Bladder Diseases
Breast Neoplasms Antibodies	>1 publications with FKBP1A and Breast Neoplasms
Brain Diseases Antibodies	>1 publications with FKBP1A and Brain Diseases
Neoplasms, Experimental Antibodies	>1 publications with FKBP1A and Neoplasms, Experimental