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Transcobalamin-1 (TCN1) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS949899

Binds vitamin B12 with femtomolar affinity and protects it from the acidic environment of the stomach. More details

$315 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Transcobalamin-1 (TCN1), Recombinant Protein
Full Product Name
Recombinant Human Transcobalamin-1
Product Gene Name
Sequence
EICEVSEENY IRLKPLLNTM IQSNYNRGTS AVNVVLSLKL VGIQIQTLMQ KMIQQIKYNV KSRLSDVSSG ELALIILALG VCRNAEENLI YDYHLIDKLE NKFQAEIENM EAHNGTPLTN YYQLSLDVLA LCLFNGNYST AEVVNHFTPE NKNYYFGSQF SVDTGAMAVL ALTCVKKSLI NGQIKADEGS LKNISIYTKS LVEKILSEKK ENGLIGNTFS TGEAMQALFV SSDYYNENDW NCQQTLNTVL TEISQGAFSN PNAAAQVLPA LMGKTFLDIN KDSSCVSASG NFNISADEPI TVTPPDSQSY ISVNYSVRIN ETYFTNVTVL NGSVFLSVME KAQKMNDTIF GFTMEERSWG PYITCIQGLC ANNNDRTYWE LLSGGEPLSQ GAGSYVVRNG ENLEVRWSKY
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Molecular Weight
47.6 kDa
Sequence Positions
24-433. Full Length of Mature Protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
189905
3D Structure
ModBase 3D Structure for P20061
Production Note
Special Offer: The E Coli, Yeast host-expressed protein is manufactured from a stock plasmid containing the protein gene. E Coli, Yeasthost-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The E Coli, Yeast host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select E Coli, Yeast host-expressed protein for the fastest delivery among all hosts. Please contact our technical support team or email to support@mybiosource.com for more details.

Product Categories/Family for TCN1 recombinant protein

ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of TCN1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TCN1 purchase

MBS949899 is a recombinant protein targeting TCN1. Also known as Recombinant Human Transcobalamin-1. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for TCN1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
transcobalamin-1
NCBI Official Synonym Full Names
transcobalamin 1
NCBI Official Symbol
TCN1
NCBI Official Synonym Symbols
HC; TC1; TCI; TC-1
UniProt Protein Name
Transcobalamin-1
UniProt Synonym Protein Names
Haptocorrin; HC; Protein R; Transcobalamin I; TC I; TCI
Protein Family
UniProt Gene Name
TCN1
UniProt Synonym Gene Names
TC1; TC-1; HC; TC I; TCI
UniProt Entry Name
TCO1_HUMAN
NCBI Protein Information
transcobalamin-1

NCBI Summary for TCN1

This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This protein is a major constituent of secondary granules in neutrophils and facilitates the transport of cobalamin into cells. [provided by RefSeq, Jul 2008]
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UniProt Comments for TCN1

TCN1: Vitamin B12-binding protein. Transports cobalamin into cells. Belongs to the eukaryotic cobalamin transport proteins family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 11q11-q12

Cellular Component: extracellular region; extracellular space

Molecular Function: cobalamin binding

Biological Process: cobalamin metabolic process; cobalamin transport; cobalt ion transport; vitamin metabolic process; water-soluble vitamin metabolic process
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Research Articles on TCN1

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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