Human NEFH Recombinant Protein – Cat# MBS950061

Neurofilament Heavy Polypeptide (NEFH), Partial (NEFH) Human Recombinant Protein

Name: NEFH Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS950061
Price: 455 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS950061

Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. NF-H has an important function in mature axons that is not subserved by the two smaller NF proteins. More details

$455 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Neurofilament heavy polypeptide (NEFH), partial, Recombinant Protein

Full Product Name

Recombinant Human Neurofilament heavy polypeptide (NEFH), partial

Product Gene Name

NEFH recombinant protein

Product Synonym Gene Name

NEFH; KIAA0845; NFH

Product Synonym Names

Neurofilament heavy polypeptide; NF-H; 200 kDa neurofilament protein; Neurofilament triplet H protein

Sequence

MMSFGGADAL LGAPFAPLHG GGSLHYALAR KGGAGGTRSA AGSSSGFHSW TRTSVSSVSA SPSRFRGAGA ASSTDSLDTL SNGPEGCMVA VATSRSEKEQ LQALNDRFAG YIDKVRQLEA HNRSLEGEAA ALRQQQAGRS AMGELYEREV REMRGAVLRL GAARGQLRLE QEHLLEDIAH VRQRLDDEAR QREEAEAAAR ALARFAQEAE AARVDLQKKA QALQEECGYL RRHHQEEVGE LLGQIQGSGA AQAQMQAETR DALKCDVTSA LREIRAQLEG HAVQSTLQSE EWFRVRLDRL SEAAKVNTDA MRSAQEEITE YRRQLQARTT ELEALKSTKD SLERQRSELE DRHQADIASY QEAIQQLDAE LRNTKWEMAA QLREYQDLLN VKMALDIEIA AYRKLLEGEE CRI

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

65.6 kDa

Sequence Positions

1-413aa; Partial

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

162230

3D Structure

ModBase 3D Structure for P12036

Species

Homo sapiens (Human)

Production Note

Special Offer: The E Coli host-expressed protein is manufactured from a stock plasmid containing the protein gene. E Colihost-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The E Coli host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select E Coli host-expressed protein for the fastest delivery among all hosts. Please contact our technical support team or email to support@mybiosource.com for more details.

Product Categories/Family for NEFH recombinant protein

Neuroscience

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of NEFH recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NEFH purchase

MBS950061 is a recombinant protein targeting NEFH. Also known as Recombinant Human Neurofilament heavy polypeptide (NEFH), partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for NEFH. It may not necessarily be applicable to this product.

NCBI GI #

32483416

NCBI GeneID

4744

NCBI Accession #

NP_066554.2

UniProt Primary Accession #

P12036

UniProt Secondary Accession #

Q96HF8; Q9UJS7; Q9UQ14; B4DYY4

UniProt Related Accession #

P12036

GenBank Nucleotide #

NM_021076.3

NCBI Official Full Name

neurofilament heavy polypeptide

NCBI Official Synonym Full Names

neurofilament, heavy polypeptide

NCBI Official Symbol

NEFH

NCBI Official Synonym Symbols

NFH

UniProt Protein Name

Neurofilament heavy polypeptide

UniProt Synonym Protein Names

200 kDa neurofilament protein; Neurofilament triplet H protein

Protein Family

Neurofilament heavy polypeptide

UniProt Gene Name

NEFH

UniProt Synonym Gene Names

KIAA0845; NFH; NF-H

UniProt Entry Name

NFH_HUMAN

NCBI Protein Information

neurofilament heavy polypeptide; NF-H; 200 kDa neurofilament protein; neurofilament triplet H protein; neurofilament, heavy polypeptide 200kDa

NCBI Summary for NEFH

Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene. [provided by RefSeq, Oct 2008]

UniProt Comments for NEFH

NFH: Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. NF-H has an important function in mature axons that is not subserved by the two smaller NF proteins. Belongs to the intermediate filament family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 22q12.2

Cellular Component: mitochondrion; axon; cytoplasm; neurofilament

Molecular Function: protein binding, bridging; dynein binding; structural constituent of cytoskeleton; kinesin binding; microtubule binding; structural molecule activity; protein kinase binding

Biological Process: neurofilament bundle assembly; axonogenesis; cell projection biogenesis; microtubule cytoskeleton organization and biogenesis; peripheral nervous system neuron axonogenesis

Disease: Amyotrophic Lateral Sclerosis 1

Research Articles on NEFH

1. Subconcussive repetitive trauma in amateur boxing causes a mild traumatic brain injury that may be diagnosed by CSF analysis of expressed pNFH, even without unconsciousness or concussion symptoms.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with NEFH recombinant protein

Reference Product	PubMed Publications
NEFL recombinant protein	>3 publications with NEFH and NEFL
PRPH recombinant protein	>1 publications with NEFH and PRPH

Pathways associated with NEFH recombinant protein

Products by Pathway	Pathway Diagram
Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies	Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies	Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram

Diseases associated with NEFH recombinant protein

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>13 publications with NEFH and Nervous System Diseases
Neoplasms Antibodies	>7 publications with NEFH and Neoplasms
Brain Diseases Antibodies	>4 publications with NEFH and Brain Diseases
Drug Toxicity Antibodies	>3 publications with NEFH and Drug Toxicity
Death Antibodies	>3 publications with NEFH and Death
Brain Injuries Antibodies	>2 publications with NEFH and Brain Injuries
Disease Models, Animal Antibodies	>1 publications with NEFH and Disease Models, Animal
Atrophy Antibodies	>1 publications with NEFH and Atrophy
Poisoning Antibodies	>1 publications with NEFH and Poisoning
Neurotoxicity Syndromes Antibodies	>1 publications with NEFH and Neurotoxicity Syndromes

Organs/Tissues associated with NEFH recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>8 publications with NEFH and Brain
Nerve Antibodies	>7 publications with NEFH and Nerve
Spinal Cord Antibodies	>2 publications with NEFH and Spinal Cord
Testis Antibodies	>2 publications with NEFH and Testis
Eye Antibodies	>2 publications with NEFH and Eye
Ear Antibodies	>1 publications with NEFH and Ear
Heart Antibodies	>1 publications with NEFH and Heart
Bone Marrow Antibodies	>1 publications with NEFH and Bone Marrow