Human GRIK1 Recombinant Protein – Cat# MBS950063

Glutamate Receptor, Ionotropic Kainate 1 (GRIK1) Human Recombinant Protein

Name: GRIK1 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS950063
Price: 1895 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS950063

MBS950063 is a recombinant protein targeting GRIK1. Also known as Recombinant Human Glutamate receptor, ionotropic kainate 1 (GRIK1) , partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$1895 / 1 mg (E-Coli) +2 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Glutamate receptor, ionotropic kainate 1 (GRIK1), Recombinant Protein

Full Product Name

Recombinant Human Glutamate receptor, ionotropic kainate 1 (GRIK1) , partial

Product Gene Name

GRIK1 recombinant protein

Sequence

QTAPQVLRIG GIFETVENEP VNVEELAFKF AVTSINRNRT LMPNTTLTYD IQRINLFDSF EASRRACDQL ALGVAALFGP SHSSSVSAVQ SICNALEVPH IQTRWKHPSV DNKDLFYINL YPDYAAISRA ILDLVLYYNW KTVTVVYEDS TGLIRLQELI KAPSRYNIKI KIRQLPSGNK DAKPLLKEMK KGKEFYVIFD CSHETAAEIL KQILFMGMMT EYYHYFFTTL DLFALDLELY RYSGVNMTGF RLLNIDNPHV SSIIEKWSME RLQAPPRPET GLLDGMMTTE AALMYDAVYM VAIASHRASQ LTVSSLQCHR HKPWRLGPRF MNLIKEARWD GLTGHITFNK TNGLRKDFDL DIISLKEEGT EKAAGEVSKH LYKVWKKIGI WNSNSGLNMT DSNKDKSSNI TDSLANRTLI VTTILEEPYV MYRKSDKPLY GNDRFEGYCL DLLKELSNIL GFIYDVKLVP DGKYGAQNDK GEWNGMVKEL IDHRADLAVA PLTITYVREK VIDFSKPFMT LGISILYRKP NGTNPGVFSF LNPLSPDIWM YVLLACLGVS CVLFVIARFT PYEWYNPHPC NPDSDVVENN FTLLNSFWFG VGALMQQGSE LMPKALSTRI VGGIWWFFTL IIISSYTANL AAFLTVERME SPIDSADDLA KQTKIEYGAV RDGSTMTFFK KSKISTYEKM WAFMSSRQQT ALVRNSDEGI QRVLTTDYAL LMESTSIEYV TQRNCNLTQI GGLIDSKGYG VGTPIGSPYR DKITIAILQL QEEGKLHMMK EKWWRGNGCP EEDNKEASAL GVENIGGIFI VLAAGLVLSV FVAIGEFIYK SRKNNDIEQA FCFFYGLQCK QTHPTNSTSG TTLSTDLECG KLIREERGIR KQSSVHTV

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

102,631 Da

Sequence Positions

31-918

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

138245

3D Structure

ModBase 3D Structure for P39086

Species

Homo sapiens (Human)

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of GRIK1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GRIK1. It may not necessarily be applicable to this product.

NCBI GI #

4504117

NCBI GeneID

2897

NCBI Accession #

NP_000821.1

UniProt Primary Accession #

P39086

UniProt Secondary Accession #

Q13001; Q86SU9

UniProt Related Accession #

P39086

GenBank Nucleotide #

NM_000830.4

NCBI Official Full Name

glutamate receptor ionotropic, kainate 1 isoform 1

NCBI Official Synonym Full Names

glutamate ionotropic receptor kainate type subunit 1

NCBI Official Symbol

GRIK1

NCBI Official Synonym Symbols

EAA3; EEA3; GLR5; GLUR5; GluK1; gluR-5

UniProt Protein Name

Glutamate receptor ionotropic, kainate 1

UniProt Synonym Protein Names

Excitatory amino acid receptor 3; EAA3; Glutamate receptor 5; GluR-5; GluR5

Protein Family

Glutamate receptor ionotropic

UniProt Gene Name

GRIK1

UniProt Synonym Gene Names

GLUR5; GluK1; EAA3; GluR-5; GluR5

NCBI Protein Information

glutamate receptor ionotropic, kainate 1

NCBI Summary for GRIK1

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene. [provided by RefSeq, Jul 2008]

UniProt Comments for GRIK1

Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.

Research Articles on GRIK1

1. DRD2 A2/A1, DRD3 Ser9Gly, DbetaH -1021C>T, OPRM1 A118G and GRIK1 rs2832407C>A are not associated with alcoholism alone or in interaction.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with GRIK1 recombinant protein

Products by Pathway	Pathway Diagram
Activation Of Ca-permeable Kainate Receptor Pathway antibodies	Activation Of Ca-permeable Kainate Receptor Pathway Diagram
Activation Of Kainate Receptors Upon Glutamate Binding Pathway antibodies	Activation Of Kainate Receptors Upon Glutamate Binding Pathway Diagram
Activation Of Na-permeable Kainate Receptors Pathway antibodies	Activation Of Na-permeable Kainate Receptors Pathway Diagram
Glutamatergic Synapse Pathway antibodies	Glutamatergic Synapse Pathway Diagram
Glutamatergic Synapse Pathway antibodies	Glutamatergic Synapse Pathway Diagram
Ionotropic Activity Of Kainate Receptors Pathway antibodies	Ionotropic Activity Of Kainate Receptors Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
Neuronal System Pathway antibodies	Neuronal System Pathway Diagram
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway antibodies	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway Diagram

Diseases associated with GRIK1 recombinant protein

Disease Name	Pubmed Publications
Epilepsy Antibodies	>5 publications with GRIK1 and Epilepsy
Nervous System Diseases Antibodies	>5 publications with GRIK1 and Nervous System Diseases
Brain Diseases Antibodies	>3 publications with GRIK1 and Brain Diseases
Pain Antibodies	>2 publications with GRIK1 and Pain
Seizures Antibodies	>2 publications with GRIK1 and Seizures
Liver Diseases Antibodies	>1 publications with GRIK1 and Liver Diseases
Cognition Disorders Antibodies	>1 publications with GRIK1 and Cognition Disorders
Inflammation Antibodies	>1 publications with GRIK1 and Inflammation
Learning Disorders Antibodies	>1 publications with GRIK1 and Learning Disorders

Organs/Tissues associated with GRIK1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>6 publications with GRIK1 and Brain
Embryonic Tissue Antibodies	>1 publications with GRIK1 and Embryonic Tissue