Mouse CD86 Recombinant Protein – Cat# MBS950117

T-Lymphocyte Activation Antigen CD86 (CD86) Mouse Recombinant Protein

Name: CD86 Recombinant Protein; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS950117
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS950117

MBS950117 is a recombinant protein targeting Cd86. Also known as Recombinant Mouse T-lymphocyte activation antigen CD86 (Cd86). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

T-lymphocyte activation antigen CD86 (Cd86), Recombinant Protein

Full Product Name

Recombinant Mouse T-lymphocyte activation antigen CD86 (Cd86)

Product Gene Name

Cd86 recombinant protein

Product Synonym Names

T-lymphocyte activation antigen CD86; Activation B7-2 antigen; Early T-cell costimulatory molecule 1; ETC-1; CD_antigen=; CD86

Sequence

VSVETQA YFNGTAYLPC PFTKAQNISL SELVVFWQDQ QKLVLYEHYL GTEKLDSVNA KYLGRTSFDR NNWTLRLHNV QIKDMGSYDC FIQKKPPTGS IILQQTLTEL SVIANFSEPE IKLAQNVTGN SGINLTCTSK QGHPKPKKMY FLITNSTNEY GDNMQISQDN VTELFSISNS LSLSFPDGVW HMTVVCVLET ESMKISSKPL NFTQEFPSPQ TYWK

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

33,962 Da

Sequence Positions

24-244

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

3D Structure

ModBase 3D Structure for P42082

Species

Mus musculus (Mouse)

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Cd86 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Cd86. It may not necessarily be applicable to this product.

NCBI GI #

161484599

NCBI GeneID

12524

NCBI Accession #

NP_062261.3

UniProt Primary Accession #

P42082

UniProt Related Accession #

P42082

GenBank Nucleotide #

NM_019388.3

NCBI Official Full Name

T-lymphocyte activation antigen CD86

NCBI Official Synonym Full Names

CD86 antigen

NCBI Official Symbol

Cd86

NCBI Official Synonym Symbols

B7; B70; MB7; B7-2; B7.2; CLS1; Ly58; ETC-1; Ly-58; MB7-2; Cd28l2; TS/A-2

UniProt Protein Name

T-lymphocyte activation antigen CD86

UniProt Synonym Protein Names

Activation B7-2 antigen; Early T-cell costimulatory molecule 1; ETC-1; CD_antigen: CD86

Protein Family

T-lymphocyte activation antigen

UniProt Gene Name

Cd86

UniProt Synonym Gene Names

ETC-1

UniProt Entry Name

CD86_MOUSE

NCBI Protein Information

T-lymphocyte activation antigen CD86; activation B7-2 antigen; early T cell costimulatory molecule-1; early T-cell costimulatory molecule 1

UniProt Comments for Cd86

CD86: Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T- cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Immunoglobulin superfamily

Cellular Component: cell surface; membrane; intracellular membrane-bound organelle; integral to membrane; plasma membrane; external side of plasma membrane

Molecular Function: receptor binding

Biological Process: B cell activation; negative regulation of T cell anergy; immune system process; toll-like receptor signaling pathway; positive regulation of T cell proliferation; positive regulation of activated T cell proliferation; defense response to virus

Research Articles on Cd86

1. CD4(+) NKG2D(+) T cells induce NKG2D down-regulation in natural killer cells in CD86-RAE-1epsilon transgenic mice.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Cd86 recombinant protein

Reference Product	PubMed Publications
CD80 recombinant protein	>4089 publications with Cd86 and CD80
CD28 recombinant protein	>1006 publications with Cd86 and CD28
CTLA4 recombinant protein	>591 publications with Cd86 and CTLA4
MARCH8 recombinant protein	>1 publications with Cd86 and MARCH8

Pathways associated with Cd86 recombinant protein

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Allograft Rejection Pathway antibodies	Allograft Rejection Pathway Diagram
Allograft Rejection Pathway antibodies	Allograft Rejection Pathway Diagram
Autoimmune Thyroid Disease Pathway antibodies	Autoimmune Thyroid Disease Pathway Diagram
Autoimmune Thyroid Disease Pathway antibodies	Autoimmune Thyroid Disease Pathway Diagram
CD28 Co-stimulation Pathway antibodies	CD28 Co-stimulation Pathway Diagram
CD28 Dependent PI3K/Akt Signaling Pathway antibodies	CD28 Dependent PI3K/Akt Signaling Pathway Diagram
CD28 Dependent Vav1 Pathway antibodies	CD28 Dependent Vav1 Pathway Diagram
CTLA4 Inhibitory Signaling Pathway antibodies	CTLA4 Inhibitory Signaling Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram

Diseases associated with Cd86 recombinant protein

Disease Name	Pubmed Publications
Necrosis Antibodies	>1119 publications with Cd86 and Necrosis
Inflammation Antibodies	>789 publications with Cd86 and Inflammation
Nervous System Diseases Antibodies	>277 publications with Cd86 and Nervous System Diseases
Lung Diseases Antibodies	>268 publications with Cd86 and Lung Diseases
Neoplasms, Experimental Antibodies	>201 publications with Cd86 and Neoplasms, Experimental
Liver Diseases Antibodies	>187 publications with Cd86 and Liver Diseases
Cardiovascular Diseases Antibodies	>175 publications with Cd86 and Cardiovascular Diseases
Brain Diseases Antibodies	>145 publications with Cd86 and Brain Diseases
Dermatitis, Contact Antibodies	>105 publications with Cd86 and Dermatitis, Contact
Kidney Diseases Antibodies	>86 publications with Cd86 and Kidney Diseases

Organs/Tissues associated with Cd86 recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>4595 publications with Cd86 and Blood
Spleen Antibodies	>592 publications with Cd86 and Spleen
Lymph Node Antibodies	>560 publications with Cd86 and Lymph Node
Lung Antibodies	>290 publications with Cd86 and Lung
Vascular Antibodies	>160 publications with Cd86 and Vascular
Kidney Antibodies	>136 publications with Cd86 and Kidney
Brain Antibodies	>122 publications with Cd86 and Brain
Thymus Antibodies	>106 publications with Cd86 and Thymus
Eye Antibodies	>71 publications with Cd86 and Eye
Pancreas Antibodies	>38 publications with Cd86 and Pancreas