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5-Hydroxytryptamine Receptor 5a (HTR5A) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS950161

MBS950161 is a recombinant protein targeting HTR5A. Also known as Recombinant Human 5-hydroxytryptamine receptor 5A (HTR5A). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
5-hydroxytryptamine receptor 5A (HTR5A), Recombinant Protein
Full Product Name
Recombinant Human 5-hydroxytryptamine receptor 5A (HTR5A)
Product Gene Name
HTR5A recombinant protein
Product Synonym Gene Name
HTR5A
Product Synonym Names
Recombinant 5-hydroxytryptamine receptor 5A (HTR5A); 5-hydroxytryptamine receptor 5A; 5-HT-5; 5-HT-5A; 5-HT5A; Serotonin receptor 5A
Sequence
MDLPVNLTSF SLSTPSPLET NHSLGKDDLR PSSPLLSVFG VLILTLLGFL VAATFAWNLL VLATILRVRT FHRVPHNLVA SMAVSDVLVA ALVMPLSLVH ELSGRRWQLG RRLCQLWIAC DVLCCTASIW NVTAIALDRY WSITRHMEYT LRTRKCVSNV MIALTWALSA VISLAPLLFG WGETYSEGSE ECQVSREPSY AVFSTVGAFY LPLCVVLFVY WKIYKAAKFR VGSRKTNSVS PISEAVEVKD SAKQPQMVFT VRHATVTFQP EGDTWREQKE QRAALMVGIL IGVFVLCWIP FFLTELISPL CSCDIPAIWK SIFLWLGYSN SFFNPLIYTA FNKNYNSAFK NFFSRQH
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
Molecular Weight
40,255 Da
Sequence Positions
1-357
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Chromosome Location
Chromosome: 7; NC_000007.13 (154862034..154879102). Location: 7q36.1
OMIM
601305
3D Structure
ModBase 3D Structure for P47898
Species
Homo sapiens (Human)
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of HTR5A recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for HTR5A. It may not necessarily be applicable to this product.

NCBI GI #
13236497
NCBI GeneID
3361
NCBI Accession #
NP_076917.1
UniProt Primary Accession #
P47898
UniProt Secondary Accession #
Q2M2D2
UniProt Related Accession #
P47898
GenBank Nucleotide #
NM_024012.3
NCBI Official Full Name
5-hydroxytryptamine receptor 5A
NCBI Official Synonym Full Names
5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled
NCBI Official Symbol
HTR5A
NCBI Official Synonym Symbols
5-HT5A
UniProt Protein Name
5-hydroxytryptamine receptor 5A
UniProt Synonym Protein Names
Serotonin receptor 5A
Protein Family
5-hydroxytryptamine receptor
UniProt Gene Name
HTR5A
UniProt Synonym Gene Names
5-HT-5; 5-HT-5A; 5-HT5A
UniProt Entry Name
5HT5A_HUMAN
NCBI Protein Information
5-hydroxytryptamine receptor 5A; 5-HT-5; 5-HT-5A; serotonin receptor 5A

NCBI Summary for HTR5A

The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has been implicated in a wide range of psychiatric conditions and also has vasoconstrictive and vasodilatory effects. The gene described in this record is a member of 5-hydroxytryptamine (serotonin) receptor family and encodes a multi-pass membrane protein that functions as a receptor for 5-hydroxytryptamine and couples to G-proteins. This protein has been shown to function in part through the regulation of intracellular Ca2+ mobilization. [provided by RefSeq, Jul 2008]
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UniProt Comments for HTR5A

5-HT(5A): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 7q36.1

Cellular Component: Golgi apparatus; rough endoplasmic reticulum; integral to plasma membrane; dendrite; plasma membrane; perikaryon

Molecular Function: serotonin receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to cyclic nucleotide second messenger; cAMP-mediated signaling; hippocampus development; response to estradiol stimulus; serotonin receptor signaling pathway
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Research Articles on HTR5A

1. Childhood anxiousness did not mediate the effects of HTR2A and HTR5A on mood disorders.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with HTR5A recombinant protein

 Products by Pathway  Pathway Diagram
 Amine Ligand-binding Receptors Pathway antibodies  Amine Ligand-binding Receptors Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Monoamine GPCRs Pathway antibodies  Monoamine GPCRs Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram

Diseases associated with HTR5A recombinant protein

 Disease Name  Pubmed Publications
 Depressive Disorder Antibodies  >1 publications with HTR5A and Depressive Disorder
 Cognition Disorders Antibodies  >1 publications with HTR5A and Cognition Disorders
 Fatigue Antibodies  >1 publications with HTR5A and Fatigue
 Autistic Disorder Antibodies  >1 publications with HTR5A and Autistic Disorder

Organs/Tissues associated with HTR5A recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >6 publications with HTR5A and Brain
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