Rat ACACA Recombinant Protein – Cat# MBS950263

Acetyl-Coa Carboxylase 1 (ACACA) Rat Recombinant Protein

Name: ACACA Recombinant Protein; Acetyl-Coa Carboxylase 1; Rat; MyBioSource
Brand: MyBioSource
SKU: MBS950263
Price: 315 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS950263

Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. More details

$315 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Acetyl-CoA carboxylase 1 (Acaca), Recombinant Protein

Full Product Name

Recombinant Rat Acetyl-CoA carboxylase 1 (Acaca), partial

Product Gene Name

Acaca recombinant protein

Product Synonym Names

ACC-alpha

Sequence

VIEKVLIANN GIAAVKCMRS IRRWSYEMFR NERAIRFVVM VTPEDLKANA EYIKMADHYV PVPGGANNNN YANVELILDI AKRIPVQAVW AGWGHASENP KLPELLLKNG IAFMGPPSQA MWALGDKIAS SIVAQTAGIP TLPWSGSGLR VDWQENDFSK RILNVPQDLY EKGYVKDVDD GLKAAEEVGY PVMIKASEGG GGKGIRKVNN ADDFPNLFRQ VQAEVPGSPI FVMRLAKQSR HLEVQILADQ YGNAISLFGR DCSVQRRHQK IIEEAPAAIA TPAVFEHMEQ CAVKLAKMVG YVSAGTVEYL YSQDGSFYFL ELNPRLQVEH PCTEMVADVN LPAAQLQIAM GIPLFRIKDI RMMYGVSPWG DAPIDFENSA HVPCPRGHVI AARITSENPD EGFKPSSGTV QELNFRSNKN VWGYFSVAAA GGLHEFADSQ FGHCFSWGEN REEAISNMVV ALKELSIRGD FRTTVEYLIK LLETESFQLN RIDTGWLDRL IA

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

Molecular Weight

57.8 kDa

Sequence Positions

116-617. Partial,provide Biotin carboxylation domain

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

3D Structure

ModBase 3D Structure for P11497

Species

Rat

Product Categories/Family for Acaca recombinant protein

Cancer

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Product References and Citations for Acaca recombinant protein

"Structure of the coding sequence and primary amino acid sequence of acetyl-coenzyme A carboxylase." Lopez-Casillas F., Bai D.-H., Luo X., Kong I.-S., Hermodson M.A., Kim K.-H. Proc. Natl. Acad. Sci. U.S.A. 85:5784-5788(1988)

Other Notes

Small volumes of Acaca recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Acaca purchase

MBS950263 is a recombinant protein targeting Acaca. Also known as Recombinant Rat Acetyl-CoA carboxylase 1 (Acaca), partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Acaca. It may not necessarily be applicable to this product.

NCBI GeneID

60581

NCBI Accession #

NP_071529.1

UniProt Primary Accession #

P11497

UniProt Secondary Accession #

P97902; A1EC79

UniProt Related Accession #

P11497

NCBI Official Synonym Full Names

acetyl-CoA carboxylase alpha

NCBI Official Symbol

Acaca

NCBI Official Synonym Symbols

ACC1; Acac

UniProt Protein Name

Acetyl-CoA carboxylase 1

UniProt Synonym Protein Names

ACC-alphaIncluding the following 1 domains:Biotin carboxylase (EC:6.3.4.14)

UniProt Gene Name

Acaca

UniProt Synonym Gene Names

Acac; ACC1

UniProt Entry Name

ACACA_RAT

NCBI Protein Information

acetyl-CoA carboxylase 1

NCBI Summary for Acaca

catalyzes the rate-limiting carboxylation of acetyl CoA to malonyl CoA during long-chain fatty acid synthesis [RGD, Feb 2006]

UniProt Comments for Acaca

ACC1: a subunit of acetyl-CoA carboxylase (ACC), a multifunctional enzyme system. Catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Phosphorylation by AMPK or PKA inhibits the enzymatic activity of ACC. ACC-alpha is the predominant isoform in liver, adipocyte and mammary gland. ACC-beta is the major isoform in skeletal muscle and heart. Phosphorylation regulates its activity.

Protein type: Lipid Metabolism - fatty acid biosynthesis; Ligase; EC 6.4.1.2; EC 6.3.4.14; Carbohydrate Metabolism - pyruvate; Carbohydrate Metabolism - propanoate

Cellular Component: actin cytoskeleton; cytoplasm; cytosol; mitochondrion; nucleolus

Molecular Function: acetyl-CoA carboxylase activity; ATP binding; biotin binding; biotin carboxylase activity; kinase binding; metal ion binding

Biological Process: acetyl-CoA metabolic process; fatty acid biosynthetic process; lipid homeostasis; lipid metabolic process; multicellular organismal protein metabolic process; protein homotetramerization; response to drug; response to organic cyclic substance; tissue homeostasis

Research Articles on Acaca

1. suppression of ACC1 activity impairs glucose-stimulated insulin secretion via inhibition of glucose rather than lipid metabolism.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Acaca recombinant protein

Reference Product	PubMed Publications
Fasn recombinant protein	>82 publications with Acaca and Fasn
Acly recombinant protein	>18 publications with Acaca and Acly
Acss2 recombinant protein	>8 publications with Acaca and Acss2
Acacb recombinant protein	>7 publications with Acaca and Acacb
Hlcs recombinant protein	>1 publications with Acaca and Hlcs

Pathways associated with Acaca recombinant protein

Products by Pathway	Pathway Diagram
AMPK Signaling Pathway antibodies	AMPK Signaling Pathway Diagram
AMPK Signaling Pathway antibodies	AMPK Signaling Pathway Diagram
Fatty Acid Biosynthesis Pathway antibodies	Fatty Acid Biosynthesis Pathway Diagram
Fatty Acid Biosynthesis Pathway antibodies	Fatty Acid Biosynthesis Pathway Diagram
Fatty Acid Biosynthesis Pathway antibodies	Fatty Acid Biosynthesis Pathway Diagram
Fatty Acid Biosynthesis, Initiation Pathway antibodies	Fatty Acid Biosynthesis, Initiation Pathway Diagram
Fatty Acid Biosynthesis, Initiation Pathway antibodies	Fatty Acid Biosynthesis, Initiation Pathway Diagram
Fatty Acid Metabolism Pathway antibodies	Fatty Acid Metabolism Pathway Diagram
Fatty Acid Metabolism Pathway antibodies	Fatty Acid Metabolism Pathway Diagram
Glucagon Signaling Pathway antibodies	Glucagon Signaling Pathway Diagram

Diseases associated with Acaca recombinant protein

Disease Name	Pubmed Publications
Fatty Liver Antibodies	>40 publications with Acaca and Fatty Liver
Obesity Antibodies	>22 publications with Acaca and Obesity
Liver Diseases Antibodies	>17 publications with Acaca and Liver Diseases
Inflammation Antibodies	>16 publications with Acaca and Inflammation
Insulin Resistance Antibodies	>14 publications with Acaca and Insulin Resistance
Non-alcoholic Fatty Liver Disease Antibodies	>8 publications with Acaca and Non-alcoholic Fatty Liver Disease
Weight Gain Antibodies	>6 publications with Acaca and Weight Gain
Necrosis Antibodies	>5 publications with Acaca and Necrosis
Hypertriglyceridemia Antibodies	>5 publications with Acaca and Hypertriglyceridemia
Weight Loss Antibodies	>4 publications with Acaca and Weight Loss

Organs/Tissues associated with Acaca recombinant protein

Organ/Tissue Name	Pubmed Publications
Adipose Tissue Antibodies	>50 publications with Acaca and Adipose Tissue
Liver Antibodies	>48 publications with Acaca and Liver
Brain Antibodies	>7 publications with Acaca and Brain
Ovary Antibodies	>5 publications with Acaca and Ovary
Heart Antibodies	>5 publications with Acaca and Heart
Embryonic Tissue Antibodies	>3 publications with Acaca and Embryonic Tissue
Artery Antibodies	>2 publications with Acaca and Artery
Spleen Antibodies	>1 publications with Acaca and Spleen
Prostate Antibodies	>1 publications with Acaca and Prostate