Human NGFR Recombinant Protein – Cat# MBS950269

Tumor Necrosis Factor Receptor Superfamily Member 16 (NGFR) Human Recombinant Protein

Name: NGFR Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS950269
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS950269

Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serinethreonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Tumor necrosis factor receptor superfamily member 16 (NGFR), Recombinant Protein

Full Product Name

Recombinant Human Tumor necrosis factor receptor superfamily member 16 (NGFR) , partial

Product Gene Name

NGFR recombinant protein

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

35,767 Da

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

162010

3D Structure

ModBase 3D Structure for P08138

Species

Human

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of NGFR recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NGFR purchase

MBS950269 is a recombinant protein targeting NGFR. Also known as Recombinant Human Tumor necrosis factor receptor superfamily member 16 (NGFR) , partial. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for NGFR. It may not necessarily be applicable to this product.

NCBI GI #

4505393

NCBI GeneID

4804

NCBI Accession #

NP_002498.1

UniProt Primary Accession #

P08138

UniProt Secondary Accession #

B2R961; B4E096

UniProt Related Accession #

P08138

GenBank Nucleotide #

NM_002507.3

NCBI Official Full Name

tumor necrosis factor receptor superfamily member 16

NCBI Official Synonym Full Names

nerve growth factor receptor

NCBI Official Symbol

NGFR

NCBI Official Synonym Symbols

CD271; p75NTR; TNFRSF16; p75(NTR); Gp80-LNGFR

UniProt Protein Name

Tumor necrosis factor receptor superfamily member 16

UniProt Synonym Protein Names

Gp80-LNGFR; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor; NGF receptor; p75 ICD; CD_antigen: CD271

Protein Family

Tumor necrosis factor receptor superfamily

UniProt Gene Name

NGFR

UniProt Synonym Gene Names

TNFRSF16; NGF receptor

NCBI Protein Information

tumor necrosis factor receptor superfamily member 16

NCBI Summary for NGFR

Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. [provided by RefSeq, Jul 2008]

UniProt Comments for NGFR

Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver.

Research Articles on NGFR

1. p75NTR+ cells isolated from tongue squamous cell carcinoma (TSCC) cell lines possess the characteristics of cancer stem cells; therefore, p75NTR may be considered a useful surface marker for the identification of TSCC stem cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with NGFR recombinant protein

Reference Product	PubMed Publications
NGF recombinant protein	>232 publications with NGFR and NGF
NTRK1 recombinant protein	>101 publications with NGFR and NTRK1
NTRK2 recombinant protein	>30 publications with NGFR and NTRK2
NTRK3 recombinant protein	>17 publications with NGFR and NTRK3
MAG recombinant protein	>3 publications with NGFR and MAG
NTF4 recombinant protein	>3 publications with NGFR and NTF4
MAPK1 recombinant protein	>2 publications with NGFR and MAPK1
GRB2 recombinant protein	>2 publications with NGFR and GRB2
RTN4R recombinant protein	>2 publications with NGFR and RTN4R
SHC1 recombinant protein	>2 publications with NGFR and SHC1

Pathways associated with NGFR recombinant protein

Products by Pathway	Pathway Diagram
Axonal Growth Inhibition (RHOA Activation) Pathway antibodies	Axonal Growth Inhibition (RHOA Activation) Pathway Diagram
Axonal Growth Stimulation Pathway antibodies	Axonal Growth Stimulation Pathway Diagram
BDNF Signaling Pathway antibodies	BDNF Signaling Pathway Diagram
Cell Death Signalling Via NRAGE, NRIF And NADE Pathway antibodies	Cell Death Signalling Via NRAGE, NRIF And NADE Pathway Diagram
Ceramide Signalling Pathway antibodies	Ceramide Signalling Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
NADE Modulates Death Signalling Pathway antibodies	NADE Modulates Death Signalling Pathway Diagram
NF-kB Is Activated And Signals Survival Pathway antibodies	NF-kB Is Activated And Signals Survival Pathway Diagram
NFG And ProNGF Binds To P75NTR Pathway antibodies	NFG And ProNGF Binds To P75NTR Pathway Diagram

Diseases associated with NGFR recombinant protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>158 publications with NGFR and Neoplasms
Nervous System Diseases Antibodies	>116 publications with NGFR and Nervous System Diseases
Brain Diseases Antibodies	>56 publications with NGFR and Brain Diseases
Necrosis Antibodies	>40 publications with NGFR and Necrosis
Neurodegenerative Diseases Antibodies	>34 publications with NGFR and Neurodegenerative Diseases
Nerve Degeneration Antibodies	>31 publications with NGFR and Nerve Degeneration
Inflammation Antibodies	>23 publications with NGFR and Inflammation
Disease Models, Animal Antibodies	>23 publications with NGFR and Disease Models, Animal
Mental Disorders Antibodies	>20 publications with NGFR and Mental Disorders
Kidney Diseases Antibodies	>14 publications with NGFR and Kidney Diseases

Organs/Tissues associated with NGFR recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>184 publications with NGFR and Brain
Mixed Antibodies	>9 publications with NGFR and Mixed
Spleen Antibodies	>3 publications with NGFR and Spleen