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Transforming Growth Factor Beta-3 (TGFB3) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS950272

MBS950272 is a recombinant protein targeting TGFB3. Also known as Recombinant Human Transforming growth factor beta-3. Host: E Coli or Yeast or Baculovirus or Mammalian Cell. Involved in embryogenesis and cell differentiation. More details

$315 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Transforming growth factor beta-3 (TGFB3), Recombinant Protein
Full Product Name
Recombinant Human Transforming growth factor beta-3
Product Gene Name
TGFB3 recombinant protein
Product Synonym Names
Cleaved into the following chain: Latency-associated peptide; LAP
Sequence
LSTCTTLDFG HIKKKRVEAI RGQILSKLRL TSPPEPTVMT HVPYQVLALY NSTRELLEEM HGEREEGCTQ ENTESEYYAK EIHKFDMIQG LAEHNELAVC PKGITSKVFR FNVSSVEKNR TNLFRAEFRV LRVPNPSSKR NEQRIELFQI LRPDEHIAKQ RYIGGKNLPT RGTAEWLSFD VTDTVREWLL RRESNLGLEI SIHCPCHTFQ PNGDILENIH EVMEIKFKGV DNEDDHGRGD LGRLKKQKDH HNPHLILMMI PPHRLDNPGQ GGQRKKR
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Molecular Weight
48.1 kDa
Sequence Positions
24-300aa; partial
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
107970
3D Structure
ModBase 3D Structure for P10600
Species
Homo sapiens (Human)

Product Categories/Family for TGFB3 recombinant protein

Cancer
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

SDS-PAGE of TGFB3 recombinant protein

Human TGFB3 Recombinant Protein – Cat# MBS950272

Product References and Citations for TGFB3 recombinant protein

"Identification of another member of the transforming growth factor type beta gene family." ten Dijke P., Hansen P., Iwata K., Pieler C., Foulkes J.G. Proc. Natl. Acad. Sci. U.S.A. 85:4715-4719(1988)

Other Notes

Small volumes of TGFB3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TGFB3. It may not necessarily be applicable to this product.

NCBI GI #
4507465
NCBI GeneID
7043
NCBI Accession #
NP_003230.1
UniProt Primary Accession #
P10600
UniProt Secondary Accession #
Q8WV88
UniProt Related Accession #
P10600
GenBank Nucleotide #
NM_003239.3
NCBI Official Full Name
transforming growth factor beta-3 preproprotein
NCBI Official Synonym Full Names
transforming growth factor beta 3
NCBI Official Symbol
TGFB3
NCBI Official Synonym Symbols
ARVD; RNHF; ARVD1; TGF-beta3
UniProt Protein Name
Transforming growth factor beta-3
Protein Family
Transforming growth factor
UniProt Gene Name
TGFB3
UniProt Synonym Gene Names
TGF-beta-3; LAP
UniProt Entry Name
TGFB3_HUMAN
NCBI Protein Information
transforming growth factor beta-3

NCBI Summary for TGFB3

This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and is involved in embryogenesis and cell differentiation. Defects in this gene are a cause of familial arrhythmogenic right ventricular dysplasia 1. [provided by RefSeq, Mar 2009]

UniProt Comments for TGFB3

TGFB3: Involved in embryogenesis and cell differentiation. Homodimer; disulfide-linked. Interacts with ASPN. Belongs to the TGF-beta family.

Protein type: Secreted; Secreted, signal peptide; Ligand, receptor tyrosine kinase; Cell development/differentiation; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 14q24

Cellular Component: cell soma; cell surface; extracellular matrix; extracellular region; extracellular space; nucleus; plasma membrane; proteinaceous extracellular matrix; T-tubule

Molecular Function: cytokine activity; growth factor activity; identical protein binding; protein binding; protein heterodimerization activity; punt binding; transforming growth factor beta binding

Biological Process: activation of MAPK activity; aging; alveolus development; blood coagulation; cell development; cell growth; embryonic neurocranium morphogenesis; extracellular matrix organization and biogenesis; female pregnancy; gut development; in utero embryonic development; inner ear development; intercellular junction assembly and maintenance; mammary gland development; negative regulation of cell proliferation; negative regulation of DNA replication; negative regulation of neuron apoptosis; negative regulation of transforming growth factor beta receptor signaling pathway; odontogenesis; palate development; platelet activation; platelet degranulation; positive regulation of apoptosis; positive regulation of bone mineralization; positive regulation of cell division; positive regulation of collagen biosynthetic process; positive regulation of DNA replication; positive regulation of filopodium formation; positive regulation of protein secretion; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of apoptosis; regulation of cell proliferation; regulation of MAPKKK cascade; response to estrogen stimulus; response to hypoxia; response to progesterone stimulus; salivary gland morphogenesis; SMAD protein nuclear translocation; transforming growth factor beta receptor signaling pathway; uterine wall breakdown

Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 1; Rienhoff Syndrome
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Research Articles on TGFB3

1. TGF-beta3 mediates the attenuating effect of MSCs on both the proliferation and extracellular matrix production of human keloid fibroblasts and decreases skin fibrosis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TGFB3 recombinant protein

 Reference Product  PubMed Publications
 TGFB2 recombinant protein  >607 publications with TGFB3 and TGFB2
 SMAD2 recombinant protein  >93 publications with TGFB3 and SMAD2
 SMAD3 recombinant protein  >67 publications with TGFB3 and SMAD3
 SMAD4 recombinant protein  >41 publications with TGFB3 and SMAD4
 TGFBR3 recombinant protein  >29 publications with TGFB3 and TGFBR3
 TGFBR1 recombinant protein  >15 publications with TGFB3 and TGFBR1
 TGFBR2 recombinant protein  >15 publications with TGFB3 and TGFBR2
 SMAD6 recombinant protein  >7 publications with TGFB3 and SMAD6
 FMOD recombinant protein  >2 publications with TGFB3 and FMOD
 ACVRL1 recombinant protein  >1 publications with TGFB3 and ACVRL1

Pathways associated with TGFB3 recombinant protein

 Products by Pathway  Pathway Diagram
 AGE-RAGE Signaling Pathway In Diabetic Complications antibodies  AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
 AGE-RAGE Signaling Pathway In Diabetic Complications antibodies  AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
 ALK1 Signaling Events Pathway antibodies  ALK1 Signaling Events Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram

Diseases associated with TGFB3 recombinant protein

 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >208 publications with TGFB3 and Fibrosis
 Disease Models, Animal Antibodies  >122 publications with TGFB3 and Disease Models, Animal
 Cleft Palate Antibodies  >114 publications with TGFB3 and Cleft Palate
 Cardiovascular Diseases Antibodies  >97 publications with TGFB3 and Cardiovascular Diseases
 Inflammation Antibodies  >89 publications with TGFB3 and Inflammation
 Necrosis Antibodies  >71 publications with TGFB3 and Necrosis
 Heart Diseases Antibodies  >60 publications with TGFB3 and Heart Diseases
 Lung Diseases Antibodies  >43 publications with TGFB3 and Lung Diseases
 Breast Neoplasms Antibodies  >42 publications with TGFB3 and Breast Neoplasms
 Hypertrophy Antibodies  >40 publications with TGFB3 and Hypertrophy

Organs/Tissues associated with TGFB3 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >403 publications with TGFB3 and Bone
 Connective Tissue Antibodies  >279 publications with TGFB3 and Connective Tissue
 Embryonic Tissue Antibodies  >158 publications with TGFB3 and Embryonic Tissue
 Bone Marrow Antibodies  >145 publications with TGFB3 and Bone Marrow
 Mouth Antibodies  >131 publications with TGFB3 and Mouth
 Heart Antibodies  >86 publications with TGFB3 and Heart
 Lung Antibodies  >81 publications with TGFB3 and Lung
 Eye Antibodies  >76 publications with TGFB3 and Eye
 Brain Antibodies  >75 publications with TGFB3 and Brain
 Liver Antibodies  >57 publications with TGFB3 and Liver
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