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Mothers Against Decapentaplegic Homolog 3 (SMAD3) Rat Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS950299

This protein belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene mothers against decapentaplegic (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate… More details

$1165 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Mothers against decapentaplegic homolog 3 (Smad3), Recombinant Protein
Full Product Name
Recombinant Rat Mothers against decapentaplegic homolog 3 (Smad3)
Product Gene Name
Smad3 recombinant protein
Sequence
SSILPFTPPI VKRLLGWKKG EQNGQEEKWC EKAVKSLVKK LKKTGQLDEL EKAITTQNVN TKCITIPRSL DGRLQVSHRK GLPHVIYCRL WRWPDLHSHH ELRAMELCEF AFNMKKDEVC VNPYHYQRVE TPVLPPVLVP RHTEIPAEFP PLDDYSHSIP ENTNFPAGIE PQSNIPETPP PGYLSEDGET SDHQMNHSMD AGSPNLSPNP MSPAHNNLDL QPVTYCEPAF WCSISYYELN QRVGETFHAS QPSMTVDGFT DPSNSERFCL GLLSNVNRNA AVELTRRHIG RGVRLYYIGG EVFAECLSDS AIFVQSPNCN QRYGWHPATV CKIPPGCNLK IFNNQEFAAL LAQSVNQGFE AVYQLTRMCT IRMSFVKGWG AEYRRQTVTS TPCWIELHLN GPLQWLDKVL TQMGSPSIRC SSVS
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
48,081 Da
Sequence Positions
2-425, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
3D Structure
ModBase 3D Structure for P84025
Species
Rat
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Smad3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Smad3 purchase

MBS950299 is a recombinant protein targeting Smad3. Also known as Recombinant Rat Mothers against decapentaplegic homolog 3 (Smad3). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for Smad3. It may not necessarily be applicable to this product.

NCBI GI #
6981174
NCBI GeneID
25631
NCBI Accession #
NP_037227.1
UniProt Primary Accession #
P84025
UniProt Secondary Accession #
O09064; O09144; O14510; O35273; Q92940; Q93002; Q9GKR4
UniProt Related Accession #
P84025
GenBank Nucleotide #
NM_013095.3
NCBI Official Full Name
mothers against decapentaplegic homolog 3
NCBI Official Synonym Full Names
SMAD family member 3
NCBI Official Symbol
Smad3
NCBI Official Synonym Symbols
mad3; Madh3; Smad 3
UniProt Protein Name
Mothers against decapentaplegic homolog 3
UniProt Synonym Protein Names
SMAD family member 3; SMAD 3; Smad3
Protein Family
Mothers against decapentaplegic
UniProt Gene Name
Smad3
UniProt Synonym Gene Names
Madh3; MAD homolog 3; Mad3; Mothers against DPP homolog 3; SMAD 3; Smad3
NCBI Protein Information
mothers against decapentaplegic homolog 3

NCBI Summary for Smad3

transcription factor; important component of the TGF-beta signaling pathway [RGD, Feb 2006]

UniProt Comments for Smad3

Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator ().
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Research Articles on Smad3

1. The results provide the first evidence that upregulation of TGFb/Smad3 in injured arteries induces local smooth muscle cells CXCR4 expression and cell migration, and consequently intimal hyperplasia.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Smad3 recombinant protein

 Reference Product  PubMed Publications
 Tgfb1 recombinant protein  >1624 publications with Smad3 and Tgfb1
 Tgfbr2 recombinant protein  >58 publications with Smad3 and Tgfbr2
 Tgfbr1 recombinant protein  >56 publications with Smad3 and Tgfbr1
 Fos recombinant protein  >40 publications with Smad3 and Fos
 Skil recombinant protein  >34 publications with Smad3 and Skil
 Acvr1b recombinant protein  >25 publications with Smad3 and Acvr1b
 Ppm1a recombinant protein  >13 publications with Smad3 and Ppm1a
 Foxo3 recombinant protein  >11 publications with Smad3 and Foxo3
 Acvr2b recombinant protein  >8 publications with Smad3 and Acvr2b

Pathways associated with Smad3 recombinant protein

 Products by Pathway  Pathway Diagram
 AGE-RAGE Signaling Pathway In Diabetic Complications antibodies  AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
 AGE-RAGE Signaling Pathway In Diabetic Complications antibodies  AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
 Activin Signaling Pathway antibodies  Activin Signaling Pathway Diagram
 Activin Signaling Pathway antibodies  Activin Signaling Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram

Diseases associated with Smad3 recombinant protein

 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >1248 publications with Smad3 and Fibrosis
 Disease Models, Animal Antibodies  >473 publications with Smad3 and Disease Models, Animal
 Inflammation Antibodies  >463 publications with Smad3 and Inflammation
 Liver Diseases Antibodies  >312 publications with Smad3 and Liver Diseases
 Kidney Diseases Antibodies  >284 publications with Smad3 and Kidney Diseases
 Heart Diseases Antibodies  >183 publications with Smad3 and Heart Diseases
 Liver Cirrhosis Antibodies  >173 publications with Smad3 and Liver Cirrhosis
 Breast Neoplasms Antibodies  >161 publications with Smad3 and Breast Neoplasms
 Necrosis Antibodies  >153 publications with Smad3 and Necrosis
 Neoplasm Metastasis Antibodies  >125 publications with Smad3 and Neoplasm Metastasis

Organs/Tissues associated with Smad3 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >495 publications with Smad3 and Lung
 Connective Tissue Antibodies  >381 publications with Smad3 and Connective Tissue
 Heart Antibodies  >285 publications with Smad3 and Heart
 Embryonic Tissue Antibodies  >179 publications with Smad3 and Embryonic Tissue
 Brain Antibodies  >172 publications with Smad3 and Brain
 Eye Antibodies  >100 publications with Smad3 and Eye
 Colon Antibodies  >100 publications with Smad3 and Colon
 Prostate Antibodies  >86 publications with Smad3 and Prostate
 Ovary Antibodies  >81 publications with Smad3 and Ovary
 Pancreas Antibodies  >43 publications with Smad3 and Pancreas
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