Rat DPP6 Recombinant Protein – Cat# MBS950622

Dipeptidyl Aminopeptidase-Like Protein 6 (DPP6) Rat Recombinant Protein

Name: DPP6 Recombinant Protein; Rat; MyBioSource
Brand: MyBioSource
SKU: MBS950622
Price: 385 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS950622

Promotes cell surface expression of the potassium channel KCND2. Modulates the activity and gating characteristics of the potassium channel KCND2. Has no dipeptidyl aminopeptidase activity. More details

$385 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Dipeptidyl aminopeptidase-like protein 6 (DPP6), Recombinant Protein

Full Product Name

Recombinant Rat Dipeptidyl aminopeptidase-like protein 6

Product Gene Name

DPP6 recombinant protein

Product Synonym Names

DPPX; Dipeptidyl aminopeptidase-related protein; Dipeptidyl peptidase 6; Dipeptidyl peptidase IV-like protein; Dipeptidyl peptidase VI; DPP VI

Sequence

LTPAEDTSLS QKKKVTVEDL FSEDFKIHDP EAKWISDKEF IYRERKGSVI LRNVETNNST VLIEGKKIES LRAIRYEISP DKEYALFSYN VEPVYQHSHT GYYVLSKIPH GDPQSLDPPE VSNAKLQYAG WGPKGQQLIF IFENNIYYCA HVGKQAIRVV STGKEGVIYN GLSDWLYEEE ILKSHIAHWW SPDGTRLAYA TINDSRVPLM ELPTYTGSVY PTVKPYHYPK AGSENPSISL HVIGLNGPTH DLEMMPPDDP RMREYYITMV KWATSTKVAV TWLNRAQNVS ILTLCDATTG VCTKKHEDES EAWLHRQNEE PVFSKDGRKF FFVRAIPQGG RGKFYHITVS SSQPNSSNDN IQSITSGDWD VTEILTYDEK RNKLYFLSTE DLPRRRHLYS ANTVDDFNRQ CLSCDLVENC TYVSASFSHN MDFFLLKCEG PGVPTVTVHN TTDKRRMFDL EANEQVQKAI YDRQMPKIEY RKIEVEDYSL PMQILKPATF TDTAHYPLLL VVDGTPGSQS VSERFEVTWE TVLVSSHGAV VVKCDGRGSG FQGTKLLHEV RRRLGFLEEK DQMEAVRTML KEQYIDKTRV AVFGKDYGGY LSTYILPAKG ENQGQTFTCG SALSPITDFK LYASAFSERY LGLHGLDNRA YEMTKLAHRV SALEDQQFLI IHATADEKIH FQHTAELITQ LIKGKANYSL QIYPDESHYF HSVALKQHLY RSIIGFFVEC FRIQDKLPTA TAKEDEEED

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

Molecular Weight

87.6 kDa

Sequence Positions

111-859aa; Extracellular Domain

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

3D Structure

ModBase 3D Structure for P46101

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Product References and Citations for DPP6 recombinant protein

Differential expression of two distinct forms of mRNA encoding members of a dipeptidyl aminopeptidase family.Wada K., Yokotani N., Hunter C., Doi K., Wenthold R.J., Shimasaki S.Proc. Natl. Acad. Sci. U.S.A. 89:197-201(1992) The CD26-related dipeptidyl aminopeptidase-like protein DPPX is a critical component of neuronal A-type K+ channels.Nadal M.S., Ozaita A., Amarillo Y., Vega-Saenz de Miera E., Ma Y., Mo W., Goldberg E.M., Misumi Y., Ikehara Y., Neubert T.A., Rudy B.Neuron 37:449-461(2003) Multiprotein assembly of Kv4.2, KChIP3 and DPP10 produces ternary channel complexes with ISA-like properties.Jerng H.H., Kunjilwar K., Pfaffinger P.J.J. Physiol. (Lond.) 568:767-788(2005) A novel N-terminal motif of dipeptidyl peptidase-like proteins produces rapid inactivation of KV4.2 channels by a pore-blocking mechanism.Jerng H.H., Dougherty K., Covarrubias M., Pfaffinger P.J.Channels 3:448-461(2009) The dipeptidyl-peptidase-like protein DPP6 determines the unitary conductance of neuronal Kv4.2 channels.Kaulin Y.A., De Santiago-Castillo J.A., Rocha C.A., Nadal M.S., Rudy B., Covarrubias M.J. Neurosci. 29:3242-3251(2009)

Other Notes

Small volumes of DPP6 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DPP6 purchase

MBS950622 is a recombinant protein targeting DPP6. Also known as Recombinant Rat Dipeptidyl aminopeptidase-like protein 6. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for DPP6. It may not necessarily be applicable to this product.

NCBI GI #

12408298

NCBI GeneID

29272

NCBI Accession #

NP_074041.1

UniProt Primary Accession #

P46101

UniProt Related Accession #

P46101

GenBank Nucleotide #

NM_022850.1

NCBI Official Full Name

dipeptidyl aminopeptidase-like protein 6

NCBI Official Synonym Full Names

dipeptidyl peptidase like 6

NCBI Official Symbol

Dpp6

NCBI Official Synonym Symbols

DPP VI

UniProt Protein Name

Dipeptidyl aminopeptidase-like protein 6

UniProt Synonym Protein Names

DPPX; Dipeptidyl aminopeptidase-related protein; Dipeptidyl peptidase 6; Dipeptidyl peptidase IV-like protein; Dipeptidyl peptidase VI; DPP VI

Protein Family

Dipeptidyl aminopeptidase-like protein

UniProt Gene Name

Dpp6

UniProt Synonym Gene Names

DPP VI

UniProt Entry Name

DPP6_RAT

NCBI Protein Information

dipeptidyl aminopeptidase-like protein 6

NCBI Summary for DPP6

may mediate metabolism of localized peptides [RGD, Feb 2006]

UniProt Comments for DPP6

DPP6: May be involved in the physiological processes of brain function. Has no dipeptidyl aminopeptidase activity. May modulate the cell surface expression and the activity of the potassium channel KCND2. Defects in DPP6 are the cause of familial paroxysmal ventricular fibrillation type 2 (VF2). A cardiac arrhythmia marked by fibrillary contractions of the ventricular muscle due to rapid repetitive excitation of myocardial fibers without coordinated contraction of the ventricle and by absence of atrial activity. A genetic variation 340 bases upstream from the ATG start site of the DPP6 gene is the cause of familial paroxysmal ventricular fibrillation type 2. Belongs to the peptidase S9B family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Protease

Cellular Component: cell soma; cell surface; integral to membrane; membrane; plasma membrane; voltage-gated potassium channel complex

Molecular Function: dipeptidyl-peptidase activity; potassium channel regulator activity; protein binding; serine-type peptidase activity

Biological Process: generation of action potential; positive regulation of potassium ion transport; proteolysis; regulation of membrane potential; regulation of potassium ion transport

Research Articles on DPP6

1. Dipeptidyl-peptidase 6 has an unexpected but important role in cell adhesion and motility, impacting the hippocampal synaptic development and function.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with DPP6 recombinant protein

Reference Product	PubMed Publications
Dpp8 recombinant protein	>8 publications with DPP6 and Dpp8
Kcne2 recombinant protein	>5 publications with DPP6 and Kcne2
Kcnd2 recombinant protein	>4 publications with DPP6 and Kcnd2
Kcnip2 recombinant protein	>3 publications with DPP6 and Kcnip2
Kcnip3 recombinant protein	>2 publications with DPP6 and Kcnip3
Kcnd3 recombinant protein	>2 publications with DPP6 and Kcnd3
Kcne1 recombinant protein	>2 publications with DPP6 and Kcne1

Diseases associated with DPP6 recombinant protein

Disease Name	Pubmed Publications
Amyotrophic Lateral Sclerosis Antibodies	>15 publications with DPP6 and Amyotrophic Lateral Sclerosis
Cardiovascular Diseases Antibodies	>10 publications with DPP6 and Cardiovascular Diseases
Neoplasms, Experimental Antibodies	>3 publications with DPP6 and Neoplasms, Experimental
Myocardial Infarction Antibodies	>3 publications with DPP6 and Myocardial Infarction
Child Development Disorders, Pervasive Antibodies	>3 publications with DPP6 and Child Development Disorders, Pervasive
Disease Models, Animal Antibodies	>2 publications with DPP6 and Disease Models, Animal
Learning Disorders Antibodies	>2 publications with DPP6 and Learning Disorders
Paroxysmal ventricular fibrillation Antibodies	>2 publications with DPP6 and Paroxysmal ventricular fibrillation
Weight Loss Antibodies	>2 publications with DPP6 and Weight Loss
Cardiovascular Abnormalities Antibodies	>2 publications with DPP6 and Cardiovascular Abnormalities

Organs/Tissues associated with DPP6 recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>35 publications with DPP6 and Brain
Pancreas Antibodies	>4 publications with DPP6 and Pancreas
Eye Antibodies	>2 publications with DPP6 and Eye
Dorsal Root Ganglion Antibodies	>2 publications with DPP6 and Dorsal Root Ganglion