Human PLN Recombinant Protein – Cat# MBS950658

Cardiac Phospholamban (PLN) Human Recombinant Protein

Name: PLN Recombinant Protein; Cardiac Phospholamban; Human; MyBioSource
Brand: MyBioSource
SKU: MBS950658
Price: 320 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS950658

This protein is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is… More details

$320 / 0.02 mg (Yeast) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Cardiac phospholamban (PLN), Recombinant Protein

Full Product Name

Recombinant Human Cardiac phospholamban (PLN)

Product Gene Name

PLN recombinant protein

Sequence

MEKVQYLTRS AIRRASTIEM PQQARQKLQN LFINFCLILI CLLLICIIVM LL

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

33.1 kDa

Sequence Positions

1-52aa; Full Length Protein

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

OMIM

172405

3D Structure

ModBase 3D Structure for P26678

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of PLN recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PLN purchase

MBS950658 is a recombinant protein targeting PLN. Also known as Recombinant Human Cardiac phospholamban (PLN). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for PLN. It may not necessarily be applicable to this product.

NCBI GI #

4505887

NCBI GeneID

5350

NCBI Accession #

NP_002658.1

UniProt Primary Accession #

P26678

UniProt Related Accession #

P26678

GenBank Nucleotide #

NM_002667.4

NCBI Official Full Name

cardiac phospholamban

NCBI Official Synonym Full Names

phospholamban

NCBI Official Symbol

PLN

NCBI Official Synonym Symbols

PLB; CMD1P; CMH18

UniProt Protein Name

Cardiac phospholamban

Protein Family

Cardiac phospholamban

UniProt Gene Name

PLN

UniProt Synonym Gene Names

PLB; PLB

NCBI Protein Information

cardiac phospholamban

NCBI Summary for PLN

The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy. [provided by RefSeq, Apr 2016]

UniProt Comments for PLN

Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca2+. Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation.

Research Articles on PLN

1. LMOD1, SYNPO2, PDLIM7, PLN, and SYNM down-regulation reflect the altered phenotype of smooth muscle cells in vascular disease and could be early sensitive markers of SMC dedifferentiation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PLN recombinant protein

Reference Product	PubMed Publications
SLN recombinant protein	>21 publications with PLN and SLN
ATP2A2 recombinant protein	>16 publications with PLN and ATP2A2
ATP2A1 recombinant protein	>3 publications with PLN and ATP2A1
DMPK recombinant protein	>2 publications with PLN and DMPK

Pathways associated with PLN recombinant protein

Products by Pathway	Pathway Diagram
Calcium Regulation In The Cardiac Cell Pathway antibodies	Calcium Regulation In The Cardiac Cell Pathway Diagram
Calcium Signaling Pathway antibodies	Calcium Signaling Pathway Diagram
Calcium Signaling Pathway antibodies	Calcium Signaling Pathway Diagram
Dilated Cardiomyopathy Pathway antibodies	Dilated Cardiomyopathy Pathway Diagram
Dilated Cardiomyopathy Pathway antibodies	Dilated Cardiomyopathy Pathway Diagram
Integrated Pancreatic Cancer Pathway antibodies	Integrated Pancreatic Cancer Pathway Diagram

Diseases associated with PLN recombinant protein

Disease Name	Pubmed Publications
Heart Diseases Antibodies	>100 publications with PLN and Heart Diseases
Neoplasms Antibodies	>98 publications with PLN and Neoplasms
Heart Failure Antibodies	>62 publications with PLN and Heart Failure
Inflammation Antibodies	>61 publications with PLN and Inflammation
Drug Toxicity Antibodies	>58 publications with PLN and Drug Toxicity
Disease Models, Animal Antibodies	>56 publications with PLN and Disease Models, Animal
Neoplasm Metastasis Antibodies	>54 publications with PLN and Neoplasm Metastasis
Carcinoma Antibodies	>53 publications with PLN and Carcinoma
Cardiomyopathies Antibodies	>43 publications with PLN and Cardiomyopathies
Adenocarcinoma Antibodies	>32 publications with PLN and Adenocarcinoma

Organs/Tissues associated with PLN recombinant protein

Organ/Tissue Name	Pubmed Publications
Muscle Antibodies	>198 publications with PLN and Muscle
Heart Antibodies	>188 publications with PLN and Heart
Vascular Antibodies	>77 publications with PLN and Vascular
Kidney Antibodies	>38 publications with PLN and Kidney
Pancreas Antibodies	>33 publications with PLN and Pancreas
Skin Antibodies	>31 publications with PLN and Skin
Liver Antibodies	>28 publications with PLN and Liver
Intestine Antibodies	>26 publications with PLN and Intestine
Lung Antibodies	>26 publications with PLN and Lung
Brain Antibodies	>23 publications with PLN and Brain