7,8-Dihydro-8-Oxoguanine Triphosphatase (NUDT1) Rat Recombinant Protein

Misincorporation of oxidized nucleoside triphosphates into DNA
RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. This protein is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described.

Small volumes of Nudt1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS950716 is a recombinant protein targeting Nudt1. Also known as Recombinant Rat 7,8-dihydro-8-oxoguanine triphosphatase (Nudt1). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.