T-Cell Surface Antigen CD2 (CD2) Human Recombinant Protein

CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.

Exon-intron organization and sequence comparison of human and murine T11 (CD2) genes.Diamond D.J., Clayton L.K., Sayre P.H., Reinherz E.L.Proc. Natl. Acad. Sci. U.S.A. 85:1615-1619(1988) Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure.Seed B., Aruffo A.Proc. Natl. Acad. Sci. U.S.A. 84:3365-3369(1987) Molecular cloning of the human T-lymphocyte surface CD2 (T11) antigen.Sewell W.A., Brown M.H., Dunne J., Owen M.J., Crumpton M.J.Proc. Natl. Acad. Sci. U.S.A. 83:8718-8722(1986) ErratumSewell W.A., Brown M.H., Dunne J., Owen M.J., Crumpton M.J.Proc. Natl. Acad. Sci. U.S.A. 84:7256-7256(1987) Molecular cloning and expression of T11 cDNAs reveal a receptor-like structure on human T lymphocytes.Sayre P.H., Chang H.-C., Hussey R.E., Brown N.R., Richardson N.E., Spagnoli G., Clayton L.K., Reinherz E.L.Proc. Natl. Acad. Sci. U.S.A. 84:2941-2945(1987) The structure of the human CD2 gene and its expression in transgenic mice.Lang G., Wotton D., Owen M.J., Sewell W.A., Brown M.H., Mason D.Y., Crumpton M.J., Kioussis D.EMBO J. 7:1675-1682(1988) The DNA sequence and biological annotation of human chromosome 1.Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.Nature 441:315-321(2006) Monoclonal antibody and ligand binding sites of the T cell erythrocyte receptor (CD2) .Peterson A., Seed B.Nature 329:842-846(1987) Overlapping but nonidentical binding sites on CD2 for CD58 and a second ligand CD59.Hahn W.C., Menu E., Bothwell A.L.M., Sims P.J., Bierer B.E.Science 256:1805-1807(1992) A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion.Li J., Nishizawa K., An W., Hussey R.E., Lialios F.E., Salgia R., Sunder-Plassmann R., Reinherz E.L.EMBO J. 17:7320-7336(1998) Crystal structure of the extracellular region of the human cell adhesion molecule CD2 at 2.5-A resolution.Bodian D.L., Jones E.Y., Harlos K., Stuart D.I., Davis S.J.Structure 2:755-766(1994) Structure of the glycosylated adhesion domain of human T lymphocyte glycoprotein CD2.Withka J.M., Wyss D.F., Wagner G., Arulanandam A.R.N., Reinherz E.L., Recny M.A.Structure 1:69-81(1993) Conformation and function of the N-linked glycan in the adhesion domain of human CD2.Wyss D.F., Choi J.S., Li J., Knoppers M.H., Willis K.J., Arulanandam A.R., Smolyar A., Reinherz E.L., Wagner G.Science 269:1273-1278(1995) The consensus coding sequences of human breast and colorectal cancers.Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.Science 314:268-274(2006)

Small volumes of CD2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS950822 is a recombinant protein targeting CD2. Also known as Recombinant Human T-cell surface antigen CD2. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.